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公开(公告)号：US07179816B2
公开(公告)日：2007-02-20
申请号：US10954808
申请日：2004-09-30
申请人： Patrick Mailliet , Jean-Francois Riou , Marcel Alasia , Thomas Caulfield , Gilles Doerflinger , Jean-Louis Mergny , Abdelazize Laoui , Odile Petitgenet , Emmanuelle Renou
发明人： Patrick Mailliet , Jean-Francois Riou , Marcel Alasia , Thomas Caulfield , Gilles Doerflinger , Jean-Louis Mergny , Abdelazize Laoui , Odile Petitgenet , Emmanuelle Renou
IPC分类号： C07D239/50 , C07D213/02 , C07D215/38 , A61K31/505 , A61K31/506 , A61P35/00
CPC分类号： C07D401/12 , A61K31/53 , C07D401/14 , C07D453/02
摘要： The present invention relates to cancer therapy and to novel anticancer agents having a mechanism of action which inhibits telomerase. It also relates to novel chemical compounds as well as their therapeutic application in humans.
摘要翻译： 本发明涉及癌症治疗和具有抑制端粒酶的作用机制的新型抗癌剂。 它还涉及新型化合物以及它们在人体中的治疗应用。
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公开(公告)号：US20050070575A1
公开(公告)日：2005-03-31
申请号：US10954808
申请日：2004-09-30
申请人： Patrick Mailliet , Jean-Francois Riou , Marcel Alasia , Thomas Caulfield , Gilles Doerflinger , Jean-Louis Mergny , Abdelazize Laoui , Odile Petitgenet , Emmanuelle Renou
发明人： Patrick Mailliet , Jean-Francois Riou , Marcel Alasia , Thomas Caulfield , Gilles Doerflinger , Jean-Louis Mergny , Abdelazize Laoui , Odile Petitgenet , Emmanuelle Renou
IPC分类号： A61K31/53 , A61P35/00 , C07D401/12 , C07D401/14 , C07D453/02 , A61K31/4709 , C07D41/14
CPC分类号： C07D401/12 , A61K31/53 , C07D401/14 , C07D453/02
摘要： The present invention relates to cancer therapy and to novel anticancer agents having a mechanism of action which inhibits telomerase. It also relates to novel chemical compounds as well as their therapeutic application in humans.
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公开(公告)号：US06858608B2
公开(公告)日：2005-02-22
申请号：US10040370
申请日：2002-01-09
申请人： Patrick Mailliet , Jean-François Riou , Marcel Alasia , Thomas Caulfield , Gilles Doerflinger , Jean-Louis Mergny , Abdelazize Laoui , Odile Petitgenet , Emmanuelle Renou
发明人： Patrick Mailliet , Jean-François Riou , Marcel Alasia , Thomas Caulfield , Gilles Doerflinger , Jean-Louis Mergny , Abdelazize Laoui , Odile Petitgenet , Emmanuelle Renou
IPC分类号： A61K31/53 , A61P35/00 , C07D401/12 , C07D401/14 , C07D453/02 , C07D213/02 , C07D215/38 , C07D251/48
CPC分类号： C07D401/12 , A61K31/53 , C07D401/14 , C07D453/02
摘要： The present invention relates to cancer therapy and to novel anticancer agents having a mechanism of action which inhibits telomerase. It also relates to novel chemical compounds as well as their therapeutic application in humans.
摘要翻译： 本发明涉及癌症治疗和具有抑制端粒酶的作用机制的新型抗癌剂。 它还涉及新型化合物以及它们在人体中的治疗应用。
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公开(公告)号：US07482352B2
公开(公告)日：2009-01-27
申请号：US10993637
申请日：2004-11-19
申请人： Patrick Mailliet , Abdelazize Laoui , Jean-Francois Riou , Gilles Doerflinger , Jean-Louis Mergny , Francois Hamy , Thomas Caulfield
发明人： Patrick Mailliet , Abdelazize Laoui , Jean-Francois Riou , Gilles Doerflinger , Jean-Louis Mergny , Francois Hamy , Thomas Caulfield
IPC分类号： C07D401/10 , C07D401/14 , C07D403/10 , C07D403/14 , A61K31/4427 , A61K31/4709 , A61K31/4725 , A61K31/517 , A61P35/00 , A61P35/02
CPC分类号： C07D401/14 , A61K31/53 , C07D401/12 , C07D405/14 , C07D453/02
摘要： The present invention relates to cancer therapy and to novel anticancer agents having a mechanism of action which is quite specific. It also relates to novel chemical compounds as well as their therapeutic application in humans.
摘要翻译： 本发明涉及癌症治疗和具有非常特异性的作用机制的新型抗癌剂。 它还涉及新型化合物以及它们在人体中的治疗应用。
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公开(公告)号：US06887873B2
公开(公告)日：2005-05-03
申请号：US10103883
申请日：2002-03-25
申请人： Patrick Mailliet , Abdelazize Laoui , Jean-François Riou , Gilles Doerflinger , Jean-Louis Mergny , François Hamy , Thomas Caulfield
发明人： Patrick Mailliet , Abdelazize Laoui , Jean-François Riou , Gilles Doerflinger , Jean-Louis Mergny , François Hamy , Thomas Caulfield
IPC分类号： A61K31/53 , C07D401/12 , C07D401/14 , C07D405/14 , C07D453/02
CPC分类号： C07D401/14 , A61K31/53 , C07D401/12 , C07D405/14 , C07D453/02
摘要： The present invention relates to cancer therapy and to novel anticancer agents having a mechanism of action which is quite specific. It also relates to novel chemical compounds as well as their therapeutic application in humans.
摘要翻译： 本发明涉及癌症治疗和具有非常特异性的作用机制的新型抗癌剂。 它还涉及新型化合物以及它们在人体中的治疗应用。
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公开(公告)号：US20050070571A1
公开(公告)日：2005-03-31
申请号：US10993637
申请日：2004-11-19
申请人： Patrick Mailliet , Abdekazize Laoui , Jean-Francois Riou , Gilles Doerflinger , Jean-Louis Mergny , Francois Hamy , Thomas Caulfield
发明人： Patrick Mailliet , Abdekazize Laoui , Jean-Francois Riou , Gilles Doerflinger , Jean-Louis Mergny , Francois Hamy , Thomas Caulfield
IPC分类号： A61K31/53 , C07D401/12 , C07D401/14 , C07D405/14 , C07D453/02 , A61K31/4709 , C07D41/14
CPC分类号： C07D401/14 , A61K31/53 , C07D401/12 , C07D405/14 , C07D453/02
摘要： The present invention relates to cancer therapy and to novel anticancer agents having a mechanism of action which is quite specific. It also relates to novel chemical compounds as well as their therapeutic application in humans.
摘要翻译： 本发明涉及癌症治疗和具有非常特异性的作用机制的新型抗癌剂。 它还涉及新型化合物以及它们在人体中的治疗应用。
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7.发明申请Chemical derivatives as antitelomerase agents which bind specifically to the G-quadruplex DNA structures and their application as a specific anticancer agent 审中-公开化学衍生物作为特异性结合G-四链体DNA结构的抗端粒酶试剂及其作为特异性抗癌剂的应用公开(公告)号：US20070232572A1
公开(公告)日：2007-10-04
申请号：US10773806
申请日：2004-02-06
申请人： Augustin Hittinger , Thomas Caulfield , Patrick Mailliet , Herve Bouchard , Eliane Mandine , Jean-Louis Mergny , Lionel Guittat , Jean-Francois Riou , Dennis Gomez , Chafke Belmokhtar
发明人： Augustin Hittinger , Thomas Caulfield , Patrick Mailliet , Herve Bouchard , Eliane Mandine , Jean-Louis Mergny , Lionel Guittat , Jean-Francois Riou , Dennis Gomez , Chafke Belmokhtar
IPC分类号： A61K31/47 , A61K31/497 , A61K31/56 , A61K31/66 , C07D215/00
CPC分类号： C07D401/14 , C07D215/38
摘要： The present invention relates to cancer therapy and to novel anticancer agents having a mechanism of action which is quite specific. It also relates to novel chemical compounds and their therapeutic application in humans.
摘要翻译： 本发明涉及癌症治疗和具有非常特异性的作用机制的新型抗癌剂。 它还涉及新型化合物及其在人体中的治疗应用。
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8.发明申请1,3-Diarylprop-2-en-1-ones, compositions containing them and use thereof 审中-公开1,3-二芳基丙-2-烯-1-酮，含有它们的组合物及其用途公开(公告)号：US20050203170A1
公开(公告)日：2005-09-15
申请号：US11108855
申请日：2005-04-19
申请人： Patrick Mailliet , Cecile Combeau , Marie-Christine Bissery , Marie-Pierre Cherrier , Thomas Caulfield , Gilles Tiraboschi
发明人： Patrick Mailliet , Cecile Combeau , Marie-Christine Bissery , Marie-Pierre Cherrier , Thomas Caulfield , Gilles Tiraboschi
IPC分类号： C07C225/22 , C07C237/04 , C07C279/36 , C07D207/16 , C07D209/08 , C07D405/06 , A61K31/401 , A61K31/135 , A61K31/198
CPC分类号： C07D405/06 , C07C225/22 , C07C237/04 , C07C279/36 , C07D207/16 , C07D209/08
摘要： 1,3-Diarylprop-2-en-1-ones and derivatives, compositions containing them, manufacturing process and use. Substituted 1,3-diarylprop-2-en-1-ones with therapeutic activity may be used in oncology.
摘要翻译： 1,3-二芳基丙-2-烯-1-酮及其衍生物，含有它们的组合物，制造方法和用途。 具有治疗活性的取代的1,3-二芳基丙-2-烯-1-酮可用于肿瘤学。
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9.发明授权公开(公告)号：US06887904B2
公开(公告)日：2005-05-03
申请号：US10309250
申请日：2002-12-04
IPC分类号： C07C49/84 , A61K31/122 , A61K31/136 , A61K31/277 , A61K31/403 , A61K31/47 , A61K31/473 , A61P35/00 , C07C49/825 , C07C225/22
CPC分类号： C07C49/84 , C07C225/22 , C07C2601/02 , C07C2601/04 , C07C2601/14
摘要： Substituted arylcycloalkanes, compositions containing them and use thereof. The present invention relates especially to substituted arylcycloalkanes with therapeutic activity, which may be used such as in oncology.
摘要翻译： 取代的芳基环烷烃，含有它们的组合物及其用途。 本发明特别涉及具有治疗活性的取代的芳基环烷烃，其可以用于肿瘤学。
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公开(公告)号：US5455387A
公开(公告)日：1995-10-03
申请号：US276564
申请日：1994-07-18
IPC分类号： H01L23/04 , H01L23/495 , H01L23/02
CPC分类号： H01L23/04 , H01L23/4952 , H01L23/49531 , H01L23/49534 , H01L24/48 , H01L2224/48091 , H01L2224/48247 , H01L2224/4826 , H01L2224/484 , H01L2924/00014 , H01L2924/01005 , H01L2924/01006 , H01L2924/01033 , H01L2924/01039 , H01L2924/01082 , H01L2924/14 , H01L2924/1532
摘要： An electronic package with a semiconductor chip, a lead frame, a metal casing, and a redistribution interposer. The chip is mounted on the interposer and wirebonded to first ends of redistribution leads of the interposer. The redistribution leads have second ends orientated in a general flipped orientation relative to their corresponding first ends. The second ends are wirebonded to pads of the lead frame. The interposer allows smaller chips to be used in the package without changing the lead frame. The interposer also allows the chip to be flip-mounted in the package without changing the lead frame or casing, this allows redirection of the chip's thermal path.
摘要翻译： 具有半导体芯片，引线框架，金属外壳和再分配插入件的电子封装。 芯片安装在插入器上并引线键合到插入器的再分配引线的第一端。 再分配引线具有相对于其对应的第一端以一般的翻转取向定向的第二端。 第二端与引线框的焊盘引线键合。 插入器允许在封装中使用更小的芯片而不改变引线框架。 插入器还允许将芯片翻转安装在封装中而不改变引线框架或外壳，这允许芯片的热路径重定向。
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