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    Methods, compositions and articles for reducing or preventing the effects of inflammation
    9.
    发明授权
    Methods, compositions and articles for reducing or preventing the effects of inflammation 失效
    用于减少或预防炎症作用的方法，组合物和制品

    公开(公告)号：US06274614B1

    公开(公告)日：2001-08-14

    申请号：US08942883

    申请日：1997-10-02

    申请人： Anna M. Richter ,  Julia G. Levy ,  Claude A. A. Hariton ,  Gustave Huber ,  William C. Stewart ,  Mario G. Fsadni

    发明人： Anna M. Richter ,  Julia G. Levy ,  Claude A. A. Hariton ,  Gustave Huber ,  William C. Stewart ,  Mario G. Fsadni

    IPC分类号： A61K3140

    CPC分类号： A61K41/0071 ,  Y10S514/912 ,  Y10S514/913

    摘要： A method for reducing or preventing the effects of inflammation arising from injured tissue, which method comprises the steps of: a. bringing the injured tissue, or pre-injured tissue, into contact with a photosensitizing agent capable of penetrating into the tissue, resulting in the desired degree of biodistribution in less than one hour; and b. exposing the tissue thus contacted to light having a wavelength absorbed by the photosensitizing agent for a time sufficient to reduce or prevent inflammation in the exposed tissue, but not so long as to cause necrosis or erythema of the exposed tissue, or a pharmaceutical composition or an article for reducing or preventing the effects of inflammation arising from injured tissue. The composition comprises: a. from about 1 &mgr;/mL to about 2 mg/mL of a photosensitizing agent capable of penetrating into the injured tissue, or pre-injured tissue, resulting in the desired degree of biodistribution less than one hour; and b. a pharmaceutically acceptable carrier. The article comprises: a. a photosensitizing agent capable of penetrating into the injured tissue, or pre-injured tissue, resulting in the desired degree of biodistribution in less than one hour, and b. an absorbent applicator.

    摘要翻译： 一种减少或防止受损组织引起的炎症影响的方法，该方法包括以下步骤：a。 使损伤的组织或预损伤的组织与能够渗透到组织中的光敏剂接触，在少于1小时内产生所需程度的生物分布; 安布 将由此与光敏剂吸收的波长接触的组织暴露于足以减少或防止暴露组织中的炎症的时间，但不会导致暴露组织的坏死或红斑，或药物组合物或 用于减少或预防由损伤组织引起的炎症影响的制品。组合物包括：a。 约1μg/ mL至约2mg / mL的能够渗透到损伤组织或预损伤组织的光敏剂，导致所需程度的生物分布小于1小时; 安布 药学上可接受的载体。 以及能够渗透到受损组织或预损伤组织中的光敏剂，在不到一小时内产生所需程度的生物分布，和b。 吸收性涂抹器。