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1.发明申请公开(公告)号：US20140235790A1
公开(公告)日：2014-08-21
申请号：US14125289
申请日：2012-06-11
申请人： Patrick Stayton , Matthew Manganiello , Anthony Convertine , Daniel M. Ratner , Yu-Hua Chow , Eun-Ho Song , Bilal Ghosn , Lynn Schnapp , Salka Keller , Debashish Roy
发明人： Patrick Stayton , Matthew Manganiello , Anthony Convertine , Daniel M. Ratner , Yu-Hua Chow , Eun-Ho Song , Bilal Ghosn , Lynn Schnapp , Salka Keller , Debashish Roy
CPC分类号： A61K47/58 , C08F293/005 , C08F2438/03
摘要： Provided herein are compositions and methods for intracellular delivery. The compositions are polymer compositions in which the polymer serves as a carrier for therapeutic and/or diagnostic agents. The polymer compositions are effective in targeted delivery of therapeutic and/or diagnostic agents to a cell. The polymer compositions include a targeting moiety that includes carbohydrate groups that effectively target specific cell surface receptors. The polymer compositions also include an agent binding moiety that effectively associates the therapeutic and/or diagnostic agent to be delivered to the cell.
摘要翻译： 本文提供了用于细胞内递送的组合物和方法。 组合物是其中聚合物用作治疗剂和/或诊断剂的载体的聚合物组合物。 聚合物组合物有效地向细胞靶向递送治疗剂和/或诊断剂。 聚合物组合物包括靶向部分，其包括有效靶向特定细胞表面受体的碳水化合物基团。 聚合物组合物还包括能够将待递送至细胞的治疗剂和/或诊断剂有效结合的药剂结合部分。
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公开(公告)号：US20110206617A1
公开(公告)日：2011-08-25
申请号：US13032280
申请日：2011-02-22
CPC分类号： A61K49/0043 , A61K9/0034 , A61K9/5146 , A61K31/722 , A61K39/395 , A61K45/06 , A61K49/0065 , C08B37/003 , A61K2300/00
摘要： According to one embodiment, the disclosure provides a delivery formulation including a chitosan in which the primary amines are partially modified with 4-imidazole acetic acid monohydrochloride and a therapeutic or imaging material. According to another embodiment, the disclosure provides a method for delivering a material to an epithelial or mucosal tissue comprising increasing the permeability of an epithelial or mucosal tissue by applying to said tissue a delivery formulation including a chitosan in which the primary amines are partially modified with 4-imidazole acetic acid monochlorohydride and a therapeutic or imaging material.
摘要翻译： 根据一个实施方案，本公开提供了包含壳聚糖的递送制剂，其中伯胺用4-咪唑乙酸单盐酸盐和治疗或成像材料部分地修饰。 根据另一个实施方案，本公开提供了一种将材料递送至上皮或粘膜组织的方法，包括通过向所述组织施用包含壳聚糖的递送制剂来增加上皮或粘膜组织的渗透性，其中所述伯胺部分地用 4-咪唑乙酸一氯化氢和治疗或成像材料。
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公开(公告)号：US20100311654A1
公开(公告)日：2010-12-09
申请号：US12720546
申请日：2010-03-09
申请人： Krishnendu Roy , Bilal Ghosn , Sudhir Kasturi
发明人： Krishnendu Roy , Bilal Ghosn , Sudhir Kasturi
IPC分类号： A61K31/7052 , A61K47/36 , A61K38/00 , A61K31/726 , A61K38/22 , C07H21/00 , C07H1/00 , C08B37/02 , C07H5/06 , A61P9/00
CPC分类号： A61K9/5161 , C12N15/87
摘要： The present disclosure provides compositions for enhanced delivery of therapeutic agents. Drug delivery vehicle compositions may include a modified polysaccharide (e.g. chitosan) having at least one secondary amine or at least one tertiary amine and a therapeutic agent such as a therapeutic nucleic acid and/or a therapeutic anionic agent. Various additional modifications of a modified polysaccharide of the disclosure are also described. Exemplary therapeutic agents may include but are not limited to nucleic acids, polynucleotides, siRNA and/or pDNA. Compositions of the disclosure may be formulated as nanoparticles and may provide one or more advantages including efficient transfection, bio-delivery, availability, buffering ability, serum stability. Methods for synthesizing the drug delivery compositions are also set forth. The disclosure also provides methods for delivering/administering therapeutic agents using the drug delivery compositions of the disclosure to a patient in need thereof. Therapeutic methods are also provided.
摘要翻译： 本公开提供用于增强治疗剂递送的组合物。 药物递送载体组合物可以包括具有至少一个仲胺或至少一种叔胺和治疗剂如治疗性核酸和/或治疗性阴离子剂的改性多糖（例如壳聚糖）。 还描述了本公开的改性多糖的各种另外的修饰。 示例性治疗剂可以包括但不限于核酸，多核苷酸，siRNA和/或pDNA。 本公开的组合物可以配制成纳米颗粒，并且可以提供一个或多个优点，包括有效转染，生物递送，可用性，缓冲能力，血清稳定性。 还阐述了合成药物递送组合物的方法。 本公开还提供了使用本公开的药物递送组合物向有需要的患者递送/施用治疗剂的方法。 还提供了治疗方法。
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