公开(公告)号：US20120121516A1

公开(公告)日：2012-05-17

申请号：US13382745

申请日：2010-07-07

申请人： Patrick Tabeling ,  Mickael Tanter ,  Nicolas Pannacci ,  Olivier Couture ,  Mathias Fink

发明人： Patrick Tabeling ,  Mickael Tanter ,  Nicolas Pannacci ,  Olivier Couture ,  Mathias Fink

IPC分类号： A61K49/22 ,  A61P35/00 ,  A61K9/14 ,  A61K31/7088 ,  B82Y40/00 ,  B82Y5/00

CPC分类号： A61K9/0019 ,  A61B8/0833 ,  A61B8/481 ,  A61J3/00 ,  A61K9/0009 ,  A61K9/1075 ,  A61K41/0028

摘要： The invention relates to an emulsion that can be activated by ultrasounds, comprising, in an emulsion in an aqueous solution, microparticles having a diameter of less than 10 μm and containing an active agent and a gaseous precursor in a liquid form, encapsulated by a first emulsifier. The microparticles contain nanoparticles smaller than 1 μm, in an emulsion in the gaseous precursor, each nanoparticle comprising an inner liquid that contains the active agent and is encapsulated by a second emulsifier.

摘要翻译： 本发明涉及一种能够被超声波激活的乳液，其在水溶液中的乳液中包含直径小于10μm的微粒，并且含有液体形式的活性剂和气体前体，其被第一 乳化剂。 微粒含有小于1μm的纳米颗粒，在气态前体中的乳液中，每个纳米颗粒包含含有活性剂并由第二乳化剂包封的内部液体。

公开(公告)号：US09329260B2

公开(公告)日：2016-05-03

申请号：US13993224

申请日：2011-11-29

申请人： Olivier Couture ,  Mickael Tanter ,  Mathias Fink

发明人： Olivier Couture ,  Mickael Tanter ,  Mathias Fink

IPC分类号： G01S7/52

CPC分类号： G01S7/52 ,  G01S7/52041 ,  G01S7/52046

摘要： A method of high-resolution ultrasound imaging, in which transducers are made to emit ultrasound waves in a field of observations containing micro bubbles, by making the micro bubbles burst one by one in tandem with the emissions of ultrasound waves. At each shot j of an ultrasound wave, raw reverberated signals Sj(i,t) picked up by each transducer i are recorded, and then differential signals Vj(i,t) representative of variations between successive raw signals are determined, a parabolic function Pj(x) is fitted to the differential signals corresponding to each shot j, and then a crest Aj(x0,y0) of this function Pj, corresponding to the position of the micro bubble destroyed between shots j−1 and j, is determined.

摘要翻译： 一种高分辨率超声成像方法，其中通过使微泡与超声波的发射一个接一个地突破，使得换能器在包含微气泡的观察领域中发射超声波。 在超声波的每个镜头j处，记录由每个换能器i拾取的原始混响信号Sj（i，t），然后确定表示连续原始信号之间的变化的差分信号Vj（i，t），抛物线函数 Pj（x）被拟合到对应于每个镜头j的差分信号，然后确定对应于在镜头j-1和j之间破坏的微小气泡的位置的该功能Pj的顶点Aj（x0，y0） 。

公开(公告)号：US20110190627A1

公开(公告)日：2011-08-04

申请号：US13062290

申请日：2009-09-08

申请人： Mickael Tanter ,  Vincent Servois ,  Olivier Couture ,  Mathias Fink

发明人： Mickael Tanter ,  Vincent Servois ,  Olivier Couture ,  Mathias Fink

IPC分类号： A61B6/00

CPC分类号： A61K41/0028 ,  A61B90/39 ,  A61B2090/378 ,  A61B2090/3908 ,  A61B2090/3945 ,  A61B2090/395 ,  A61K49/0043 ,  A61K49/0091 ,  A61K49/223 ,  A61K49/225

摘要： To mark an area of interest in a target medium, an initially inactivated and ultrasound-activatable optical marker is added to the medium, and then an ultrasound activation beam is emitted, being focused on the area of interest in order to locally activate the marker, which then colors the area of interest.

摘要翻译： 为了标记目标介质中的感兴趣区域，将最初失活的和可超声激活的光学标记添加到介质中，然后发射超声激活光束，聚焦在感兴趣的区域上以便局部激活标记物， 然后再对该地区进行着色。

公开(公告)号：US20130301382A1

公开(公告)日：2013-11-14

申请号：US13993224

申请日：2011-11-29

申请人： Olivier Couture ,  Mickael Tanter ,  Mathias Fink

发明人： Olivier Couture ,  Mickael Tanter ,  Mathias Fink

IPC分类号： G01S7/52

CPC分类号： G01S7/52 ,  G01S7/52041 ,  G01S7/52046

摘要： A method of high-resolution ultrasound imaging, in which transducers are made to emit ultrasound waves in a field of observations containing micro bubbles, by making the micro bubbles burst one by one in tandem with the emissions of ultrasound waves. At each shot j of an ultrasound wave, raw reverberated signals Sj(i,t) picked up by each transducer i are recorded, and then differential signals Vj(i,t) representative of variations between successive raw signals are determined, a parabolic function Pj(x) is fitted to the differential signals corresponding to each shot j, and then a crest Aj(x0,y0) of this function Pj, corresponding to the position of the micro bubble destroyed between shots j-1 and j, is determined.

摘要翻译： 一种高分辨率超声成像方法，其中通过使微泡与超声波的发射一个接一个地突破，使得换能器在包含微气泡的观察领域中发射超声波。 在超声波的每个镜头j处，记录由每个换能器i拾取的原始混响信号Sj（i，t），然后确定表示连续原始信号之间的变化的差分信号Vj（i，t），抛物线函数 Pj（x）被拟合到对应于每个镜头j的差分信号，然后确定对应于在镜头j-1和j之间破坏的微小气泡的位置的该功能Pj的顶点Aj（x0，y0） 。