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公开(公告)号：US5699014A
公开(公告)日：1997-12-16
申请号：US627403
申请日：1996-04-04
申请人： Paul A. Haefner , William J. Linder
发明人： Paul A. Haefner , William J. Linder
CPC分类号： H03F1/3211 , H03F1/3205 , H03F2200/162 , H03F2200/372
摘要： A low-noise, low-power complementary metal-oxide-semiconductor (CMOS) integrated circuit common source differential amplifier is disclosed which is capable of amplifying low amplitude cardiac signals such as those produced by atrial depolarization of the heart. The amplifier has a pair of large area p-channel input field-effect transistors (FETs) biased in weak inversion. The amplifier also has active load FETs biased in the nonsaturation (linear) region by means of a varying gate terminal voltage applied by a dynamic bias circuit. The gate terminal voltage is varied to match the temperature dependence of the output conductance of the load FETs to the temperature dependence of the transconductance of the input FETs. The gate terminal voltage also sets a dc bias point which uses the nonlinearity in the load FET output conductance to cancel nonlinearity in the input FET transconductance.
摘要翻译： 公开了一种低噪声，低功率互补金属氧化物半导体（CMOS）集成电路公共源差分放大器，其能够放大低振幅心脏信号，例如通过心脏去极化产生的心脏信号。 放大器具有一对在弱反相中偏置的大面积p沟道输入场效应晶体管（FET）。 放大器还通过由动态偏置电路施加的变化的栅极端子电压而在非饱和（线性）区域中偏置有有源负载FET。 栅极端子电压变化以匹配负载FET的输出电导的温度依赖性与输入FET的跨导的温度依赖性。 栅极端子电压还设置直流偏置点，其使用负载FET输出电导中的非线性来消除输入FET跨导中的非线性。
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公开(公告)号：US5690683A
公开(公告)日：1997-11-25
申请号：US492199
申请日：1995-06-19
CPC分类号： A61N1/3704 , Y10S128/901
摘要： An apparatus effectively removes after potential occurring after a electrical pulse is delivered in a cardiac rhythm management system such as a pacemaker system or cardioverter/defibrillator system having an electrode used for both sensing electrical activity of the heart and carrying the electrical pulse to the heart and a sense amplifier for detecting the electrical activity from the electrode. The apparatus includes a lowpass filter coupled to the electrode to filter the sensed electrical activity. A highpass filter is coupled between the lowpass filter and the sense amplifier to further filter the electrical activity passed from the lowpass filter. Equilibrium circuitry is included to allow passive filter components of the lowpass filter and the highpass filter to return to an equilibrium state following delivery of the electrical pulse.
摘要翻译： 一种装置在电脉冲在诸如起搏器系统或心脏转复器/除颤器系统的心律管理系统中传递之后有效地消除，所述心脏起搏器系统或心脏转复器/除颤器系统具有用于感测心脏的电活动并将心电的脉搏传送到心脏的电极， 用于检测来自电极的电活动的读出放大器。 该装置包括耦合到电极的低通滤波器以滤波感测的电活动。 低通滤波器耦合在低通滤波器和读出放大器之间，以进一步滤除从低通滤波器传递的电活动。 包括平衡电路，以允许低通滤波器的无源滤波器组件和高通滤波器在电脉冲传递后恢复平衡状态。
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公开(公告)号：US5620466A
公开(公告)日：1997-04-15
申请号：US514612
申请日：1995-08-14
CPC分类号： A61N1/3704
摘要： A system and method automatically adjusts a sensing threshold in a cardioverter/defibrillator which receives electrical activity of the heart and delivers shock pulses in response thereto. An amplifier amplifies the electrical activity according to a variable gain. A detection circuit detects depolarizations in the amplified electrical activity and provides a detect signal representing a cardiac event indicative of a depolarization when the amplified electrical activity exceeds a variable sensing threshold. Slow gain control circuitry adjusts the variable gain in discrete steps based on stored peak history information representing peak values of the amplified electrical activity. Template generation circuitry responds quickly to set the variable sensing threshold to a level proportional to a peak value of the amplitude of the amplified electrical activity and then decreases the variable sensing threshold from the level in discrete steps until the variable sensing threshold is at a low threshold value.
摘要翻译： 系统和方法在接收心脏的电活动并响应于其的脉冲脉冲输出的心律转换器/除颤器中自动调节感测阈值。 放大器根据可变增益放大电气活动。 检测电路检测放大的电活动中的去极化，并且当放大的电活动超过可变感测阈值时提供表示指示去极化的心脏事件的检测信号。 缓慢增益控制电路根据代表放大的电活动峰值的存储的峰值历史信息来调整离散步长中的可变增益。 模板生成电路快速响应，将可变感测阈值设置成与放大的电活动的幅度的峰值成比例的电平，然后从离散步骤中的电平减小可变感测阈值，直到变量感测阈值处于低阈值 值。
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公开(公告)号：US08554323B2
公开(公告)日：2013-10-08
申请号：US13363198
申请日：2012-01-31
申请人： Paul A. Haefner , Kristofer J. James , Kent Lee , Imad Libbus , Anthony V. Caparso , Jonathan Kwok , Yachuan Pu
发明人： Paul A. Haefner , Kristofer J. James , Kent Lee , Imad Libbus , Anthony V. Caparso , Jonathan Kwok , Yachuan Pu
IPC分类号： A61N1/365
CPC分类号： A61N1/36053 , A61B5/08 , A61B5/4035 , A61B5/4818 , A61N1/3601 , A61N1/36114
摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system synchronizes the delivery of the neural stimulation pulses to the respiratory cycles using a respiratory fiducial point in the respiratory signal and a delay interval. In another embodiment, the neural stimulation system detects a respiratory disorder and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected respiratory disorder.
摘要翻译： 神经刺激系统使用呼吸信号作为治疗反馈输入来控制神经刺激的传递。 呼吸信号用于增加神经刺激的有效性，例如迷走神经刺激，同时减少呼吸功能的潜在不利副作用。 在一个实施例中，神经刺激系统使用呼吸信号中的呼吸基准点和延迟间隔将神经刺激脉冲的传送同步到呼吸周期。 在另一个实施例中，神经刺激系统检测呼吸障碍，并且作为响应调整神经刺激脉冲的递送和/或递送治疗所检测的呼吸障碍的呼吸治疗。
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公开(公告)号：US08249717B2
公开(公告)日：2012-08-21
申请号：US11779764
申请日：2007-07-18
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/36117
摘要： A method embodiment comprises generating a neural stimulation signal for a neural stimulation therapy. The signal is generated during a duty cycle of a stimulation period to provide the neural stimulation therapy with an intensity at a therapy level for a portion of the duty cycle. In various embodiments, a ramp up protocol is implemented to begin the duty cycle, a ramp down protocol is implemented to end the duty cycle, or both the ramp up protocol and the ramp down protocol are implemented. The ramp up protocol includes ramping up the intensity from a non-zero first subthreshold level for the neural stimulation therapy at the beginning of the duty cycle to the therapy level. The ramp down protocol includes ramping down the intensity from the therapy intensity level to a non-zero second subthreshold level for the neural stimulation therapy at the end of the duty cycle.
摘要翻译： 方法实施例包括产生用于神经刺激治疗的神经刺激信号。 在刺激期的占空比期间产生信号，以在占空比的一部分的治疗水平上提供具有强度的神经刺激治疗。 在各种实施例中，实现斜坡上升协议以开始占空比，实现斜降协议以结束占空比，或者实现升温协议和斜降协议两者。 加速协议包括在占空比开始时到神经刺激治疗的非零第一亚阈值水平上升到治疗水平。 斜坡协议包括在占空比结束时将神经刺激治疗的强度从治疗强度水平向下降至非零秒次阈值水平。
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6.发明申请公开(公告)号：US20110218450A1
公开(公告)日：2011-09-08
申请号：US12715503
申请日：2010-03-02
IPC分类号： A61B5/085
摘要： Inhalation measurement systems and methods enable, during inhalant exposure, substantially real-time respiratory measurements of a test subject using techniques that obtain measurements of respiration directly from that test subject, instead of from inhalation chamber parameter measurements. Direct test subject respiratory measurements may be, by way of example only, impedance measurements. These respiratory measurements taken directly from the test subject may be transmitted, wirelessly for example, for processing during the course of the test to a processing system to determine a cumulative volume of inhalant inspired by the test subject. From that, a cumulative amount of inhalant (or dose) inspired by the test subject may be determined during the course of the inhalation compound test. In addition, a calibration procedure may be performed before the inhalant exposure to provide correlation needed to translate chest and/or abdominal wall expansion measurements, made during the test, into lung volume measurements.
摘要翻译： 吸入测量系统和方法在吸入式暴露过程中可以使用直接从该测试对象而不是从吸入室参数测量获得呼吸测量值的技术，使测试对象基本上实时呼吸测量。 直接测试对象呼吸测量可能仅作为示例，阻抗测量。 直接从测试对象取得的这些呼吸测量可以以无线方式传送，例如用于在测试过程中进行处理以处理系统以确定由测试对象启发的吸入剂的累积体积。 由此可以在吸入化合物测试过程中确定受试者启发的吸入剂（或剂量）的累积量。 此外，可以在吸入剂暴露之前进行校准程序，以提供在测试期间将胸部和/或腹壁扩张测量值转换成肺容量测量所需的相关性。
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公开(公告)号：US07702388B2
公开(公告)日：2010-04-20
申请号：US10377257
申请日：2003-02-28
申请人： Haris J. Sih , Scott A. Meyer , Paul A. Haefner
发明人： Haris J. Sih , Scott A. Meyer , Paul A. Haefner
CPC分类号： A61N1/3962
摘要： The present disclosure provides methods and systems for tachyarrhythmia therapy involving pacing the heart to prior to the application of a cardioversion/defibrillation shock. One or more pace pulses are delivered to the arrhythmic chamber or chambers. The pace pulses may be delivered to the heart at an adaptable rate selected to organize the electrical activity of the heart. If the pace pulses produce capture, cardioversion/defibrillation stimulation is delivered.
摘要翻译： 本公开提供了用于在应用心脏复律/除颤休克之前心脏起搏的快速性心律失常治疗的方法和系统。 将一个或多个步速脉冲输送到心律失常室或腔室。 速度脉冲可以以选择用于组织心脏的电活动的适应速率递送到心脏。 如果速度脉冲产生捕获，则输送心脏复律/除颤刺激。
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公开(公告)号：US20080154324A1
公开(公告)日：2008-06-26
申请号：US12008876
申请日：2008-01-15
申请人： Jaeho Kim , Joseph Bocek , Scott A. Meyer , Paul A. Haefner , Haris J. Sih
发明人： Jaeho Kim , Joseph Bocek , Scott A. Meyer , Paul A. Haefner , Haris J. Sih
IPC分类号： A61N1/37
CPC分类号： A61B5/7264 , A61B5/04525 , A61B5/7217 , A61N1/371
摘要： Methods and devices for classifying a cardiac response to pacing involve establishing a plurality of classification windows relative to and following a pacing pulse. One or more characteristics of a cardiac signal sensed following the pacing pulse are detected within one or more particular classification windows. The characteristics may be compared to one or more references. Classification of the cardiac response may be performed based on the comparison of the one or more characteristics to the one or more references and the particular classification windows in which the one or more characteristics are detected.
摘要翻译： 用于将心脏反应分类为起搏的方法和装置涉及建立相对于起搏脉冲和起搏脉冲之后的多个分类窗口。 在一个或多个特定分类窗口中检测到在起搏脉冲之后感测的心脏信号的一个或多个特征。 特征可以与一个或多个参考进行比较。 心脏反应的分类可以基于一个或多个特征与一个或多个参考和检测到一个或多个特征的特定分类窗口的比较来执行。
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公开(公告)号：US20120029372A1
公开(公告)日：2012-02-02
申请号：US13271717
申请日：2011-10-12
申请人： Paul A. Haefner , Loell Boyce Moon
发明人： Paul A. Haefner , Loell Boyce Moon
IPC分类号： A61B5/0452 , A61M5/168 , A61B5/02
CPC分类号： A61M37/00 , A61B5/021 , A61B5/0402 , A61B5/4839
摘要： Drug delivery methods and systems that include a determination of whether a cardiac condition is normal or abnormal, so that a drug may be administered in accordance with that determination. In one implementation, a drug delivery device may be controlled to reduce or stop the drug administration when a normal cardiac condition is detected. In another implementation, a patient monitoring device determines the duration that a cardiac condition is normal and provides an output indicative of the determination so that the patient may alter a therapy accordingly.
摘要翻译： 包括确定心脏病状是正常还是异常的药物递送方法和系统，以便可以根据该测定来施用药物。 在一个实施方案中，当检测到正常心脏病状时，可以控制药物递送装置以减少或停止药物施用。 在另一实现中，患者监视装置确定心脏状况正常的持续时间，并提供指示确定的输出，使得患者可以相应地改变治疗。
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10.发明授权Method and apparatus for controlling neural stimulation during disordered breathing 有权在无序呼吸期间控制神经刺激的方法和装置公开(公告)号：US08050765B2
公开(公告)日：2011-11-01
申请号：US11468603
申请日：2006-08-30
申请人： Kent Lee , Imad Libbus , Anthony V. Caparso , Jonathan Kwok , Yachuan Pu , Paul A. Haefner , Kristofer J. James
发明人： Kent Lee , Imad Libbus , Anthony V. Caparso , Jonathan Kwok , Yachuan Pu , Paul A. Haefner , Kristofer J. James
IPC分类号： A61N1/08
CPC分类号： A61N1/36135 , A61B5/0215 , A61B5/08 , A61B5/0816 , A61B5/4035 , A61B5/4818 , A61N1/3601
摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system detects apnea and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected apnea.
摘要翻译： 神经刺激系统使用呼吸信号作为治疗反馈输入来控制神经刺激的传递。 呼吸信号用于增加神经刺激的有效性，例如迷走神经刺激，同时减少呼吸功能的潜在不利副作用。 在一个实施例中，神经刺激系统检测呼吸暂停，并且作为响应调整神经刺激脉冲的传递和/或递送治疗所检测的呼吸暂停的呼吸治疗。
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