Virus preparations and methods
    9.
    发明授权
    Virus preparations and methods 失效
    病毒的准备和方法

    公开(公告)号:US06267967B1

    公开(公告)日:2001-07-31

    申请号:US09263140

    申请日:1999-03-05

    IPC分类号: A61K39245

    摘要: Herpesvirus preparations, e.g. cultured HSV type 2, e.g. genetically disabled virus for vaccine use, can be purified, e.g. for subsequent pharmaceutical formulation, with solid phase affinity reagents containing sulfate- or sulfonate-comprising binding groups, e.g. sulfated polysacharide groups, e.g. heparin or dextran sulfate, and eluting e.g. with salt solutions. The process can be combined with other culture and harvesting steps.

    摘要翻译: 疱疹病毒制剂,例如 培养的HSV 2型,例如 用于疫苗使用的遗传性残疾病毒,可以纯化,例如。 用于随后的药物制剂,其含有含硫酸盐或磺酸盐的结合基团的固相亲和试剂,例如 硫酸化多糖加合物,例如 肝素或硫酸葡聚糖, 用盐溶液。 该过程可以与其他培养和收获步骤相结合。