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    Acylaminothiazole derivatives, their preparation and therapeutic use
    2.
    发明授权
    Acylaminothiazole derivatives, their preparation and therapeutic use 有权
    酰氨基噻唑衍生物，其制备和治疗用途

    公开(公告)号：US07288659B2

    公开(公告)日：2007-10-30

    申请号：US10485837

    申请日：2002-08-05

    申请人： Paul De Cointet ,  Pierre Despeyroux ,  Daniel Frehel ,  Chantal Guenet ,  Corinne Heckel ,  Jean-Pierre Maffrand ,  Rebecca Pruss

    发明人： Paul De Cointet ,  Pierre Despeyroux ,  Daniel Frehel ,  Chantal Guenet ,  Corinne Heckel ,  Jean-Pierre Maffrand ,  Rebecca Pruss

    IPC分类号： C07D277/46

    CPC分类号： C07D417/12 ,  C07D277/40 ,  C07D277/42 ,  C07D277/46

    摘要： The invention concerns a compound of general formula (I), wherein: X represents an oxygen or sulphur atom; R1 represents, independently of each other when n=2 or 3, a halogen atom, a hydroxy, a C1-C3 alkyl, a C1-C3 alkoxy, a trifluoromethyl, a trifluoromethyloxy or a methylenedioxy; R2 represents a C1-C6 alkyl group optionally substituted, a C3-C7 cycloalkyl, piperidinyl or phenyl group, the C3-C7 cycloalkyl, piperidinyl or phenyl groups being optionally substituted; R3 represents a hydrogen atom or a C1-C6 alkyl group optionally substituted; R4 represents a hydrogen atom or a C1-C4 alkyl group; and R5 and R5′ represent, independently of each other, a hydrogen atom, a hydroxy, a halogen atom, a C1-C3 alkyl group, or R5 and R5′ form together an oxo group; R6 represents a hydrogen atom, a halogen atom, a C1-C3 alkyl, a C1-C3 alkoxy, a trifluoromethyl, or a trifluoromethoxy; in the form of a base, addition to an acid, hydrate or solvate. The invention is applicable in therapy

    摘要翻译： 本发明涉及通式（I）的化合物，其中：X表示氧或硫原子; R 1表示n = 2或3时彼此独立地表示卤素原子，羟基，C 1 -C 3烷基 C 1 -C 3烷氧基，三氟甲基，三氟甲氧基或亚甲二氧基; R 2表示任选取代的C 1 -C 6烷基，C 3 -C 6烷基， 7个环烷基，哌啶基或苯基，C 3 -C 7环烷基，哌啶基或苯基任选被取代; R 3表示任选取代的氢原子或C 1 -C 6 -C 6烷基; R 4表示氢原子或C 1 -C 4烷基; R 5和R 5'彼此独立地表示氢原子，羟基，卤素原子，C 1〜 C 3烷基或R 5和R 5'一起形成氧代基; R 6表示氢原子，卤素原子，C 1 -C 3烷基，C 1〜 -C 3烷氧基，三氟甲基或三氟甲氧基; 以碱的形式加入酸，水合物或溶剂化物。 本发明适用于治疗

    NOVEL CHEMICAL COMPOUNDS AND THE USES THEREOF AS A MEDICINE
    6.
    发明申请
    NOVEL CHEMICAL COMPOUNDS AND THE USES THEREOF AS A MEDICINE 失效
    新化学化合物及其作为医药的用途

    公开(公告)号：US20090203747A1

    公开(公告)日：2009-08-13

    申请号：US11994354

    申请日：2006-06-29

    申请人： Corinne Chaimbault ,  Cyrille Drouot ,  Laure Jamot ,  Rebecca Pruss ,  Celine Simon

    发明人： Corinne Chaimbault ,  Cyrille Drouot ,  Laure Jamot ,  Rebecca Pruss ,  Celine Simon

    IPC分类号： A61K31/426 ,  C07D277/38 ,  C07D401/02 ,  C07C337/08 ,  A61K31/437 ,  A61P25/00

    CPC分类号： C07D277/50

    摘要： The present invention relates to the field of pharmacy, especially the treatment of neurodegenerative diseases. The invention specifically relates to a family of chemical compounds for which a neuroprotective activity has been demonstrated.Given that certain members of said family are novel compounds which have never been described, the invention relates to said novel products, the synthesis method thereof and certain novel intermediate synthesis products.The present invention further relates to compositions comprising the compounds of said family, and the use of said compounds as medicaments, especially for the preparation of a medicament for the treatment of neurodegenerative diseases.

    摘要翻译： 本发明涉及药学领域，特别是治疗神经变性疾病。 本发明具体涉及已经证明了神经保护活性的化合物族。 鉴于所述家族的某些成员是未经描述的新化合物，本发明涉及所述新产品，其合成方法和某些新型中间体合成产品。 本发明还涉及包含所述家族化合物的组合物和所述化合物作为药物的用途，特别是用于制备用于治疗神经变性疾病的药物。

    Chemical compounds and the uses thereof as a medicine
    8.
    发明授权
    Chemical compounds and the uses thereof as a medicine 失效
    化合物及其作为药物的用途

    公开(公告)号：US08691854B2

    公开(公告)日：2014-04-08

    申请号：US11994354

    申请日：2006-06-29

    申请人： Corinne Chaimbault ,  Cyrille Drouot ,  Laure Jamot ,  Rebecca Pruss ,  Céline Simon

    发明人： Corinne Chaimbault ,  Cyrille Drouot ,  Laure Jamot ,  Rebecca Pruss ,  Céline Simon

    IPC分类号： A01N43/78 ,  A61K31/425 ,  C07D277/00 ,  C07D327/04 ,  C07D343/00

    CPC分类号： C07D277/50

    摘要： The present invention relates to the field of pharmacy, especially the treatment of neurodegenerative diseases. The invention specifically relates to a family of chemical compounds for which a neuroprotective activity has been demonstrated.Given that certain members of said family are novel compounds which have never been described, the invention relates to said novel products, the synthesis method thereof and certain novel intermediate synthesis products.The present invention further relates to compositions comprising the compounds of said family, and the use of said compounds as medicaments, especially for the preparation of a medicament for the treatment of neurodegenerative diseases.

    摘要翻译： 本发明涉及药学领域，特别是治疗神经变性疾病。 本发明具体涉及已经证明了神经保护活性的化合物族。 鉴于所述家族的某些成员是未经描述的新化合物，本发明涉及所述新产品，其合成方法和某些新型中间体合成产品。 本发明还涉及包含所述家族化合物的组合物和所述化合物作为药物的用途，特别是用于制备用于治疗神经变性疾病的药物。