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公开(公告)号：US6107301A
公开(公告)日：2000-08-22
申请号：US906349
申请日：1997-08-05
申请人： Paul Edward Aldrich , Argyrios Georgios Arvanitis , Rajagopal Bakthavatchalam , James Peter Beck , Robert Scott Cheeseman , Robert John Chorvat , Paul Joseph Gilligan , Carl Nicholas Hodge , Zelda Rakowitz Wasserman
发明人： Paul Edward Aldrich , Argyrios Georgios Arvanitis , Rajagopal Bakthavatchalam , James Peter Beck , Robert Scott Cheeseman , Robert John Chorvat , Paul Joseph Gilligan , Carl Nicholas Hodge , Zelda Rakowitz Wasserman
IPC分类号： A61K31/44 , A61K31/505 , A61K31/53 , A61K31/535 , C07D213/74 , C07D239/42 , C07D239/48 , C07D251/18 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D473/34 , C07D473/40 , C07D487/04 , A61K31/519
CPC分类号： C07D213/74 , A61K31/44 , A61K31/505 , A61K31/53 , A61K31/535 , C07D239/42 , C07D239/48 , C07D251/18 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D473/34 , C07D473/40 , C07D487/04
摘要： The present invention provides novel compounds, compounds and pharmaceutical compositions thereof, and methods of using same in the treatment of affective disorders, anxiety, depression, post-traumatic stress disorders, eating disorders, supranuclear palsy, irritable bowel syndrome, immune suppression, Alzheimer's disease, gastrointestinal diseases, anorexia nervosa, drug and alcohol withdrawal symptoms, drug addiction, inflammatory disorders, or fertility problems. The novel compounds provided by this invention are those of formula: ##STR1## wherein R.sup.1, R.sup.3, R.sup.4, R.sup.5, Z, Y, V, X, X', J, K, L, and M are as defined herein.
摘要翻译： 本发明提供新颖的化合物，其化合物及其药物组合物及其在治疗情感障碍，焦虑，抑郁，创伤后应激障碍，进食障碍，核上性麻痹，肠易激综合征，免疫抑制，阿尔茨海默病 ，胃肠道疾病，神经性厌食症，药物戒酒症状，药物成瘾，炎症性疾病或生殖问题。 本发明提供的新化合物是下式的化合物：其中R1，R3，R4，R5，Z，Y，V，X，X'，J，K，L和M如本文所定义。
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公开(公告)号：US06342503B1
公开(公告)日：2002-01-29
申请号：US09004150
申请日：1998-01-07
申请人： Paul Edward Aldrich , Argyrios Georgios Arvanitis , Robert Scott Cheeseman , Robert John Chorvat , Thomas Eugene Christos , Paul Joseph Gilligan , Dimitri Emil Grigoriadis , Carl Nicholas Hodge , Paul John Krenitsky , Everett Latham Scholfield , Sang William Tam , Zelda Rakowitz Wasserman
发明人： Paul Edward Aldrich , Argyrios Georgios Arvanitis , Robert Scott Cheeseman , Robert John Chorvat , Thomas Eugene Christos , Paul Joseph Gilligan , Dimitri Emil Grigoriadis , Carl Nicholas Hodge , Paul John Krenitsky , Everett Latham Scholfield , Sang William Tam , Zelda Rakowitz Wasserman
IPC分类号： C07D23942
CPC分类号： C07D213/74 , A61K31/44 , A61K31/505 , A61K31/53 , A61K31/535 , C07D239/42 , C07D239/48 , C07D251/18 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D473/34 , C07D473/40 , C07D487/04
摘要： The present invention provides novel compounds, compounds and pharmaceutical compositions thereof, and methods of using same in the treatment of affective disorders, anxiety, depression, post-traumatic stress disorders, eating disorders, supranuclear palsy, irritable bowel syndrome, immune suppression, Alzheimer'disease, gastrointestinal diseases, anorexia nervosa, drug and alcohol withdrawal symptoms, drug addiction, inflammatory disorders, or fertility problems. The novel compounds provided by this invention are those of formula: wherein R1, R3, R4, R5, Z, Y, V, X, X′, J, K, L, and M are as defined herein.
摘要翻译： 本发明提供了新的化合物，其化合物及其药物组合物及其在治疗情感障碍，焦虑，抑郁，创伤后应激障碍，进食障碍，核核后麻痹，肠易激综合征，免疫抑制，阿尔茨海默病 疾病，胃肠道疾病，神经性厌食症，药物和酒精戒断症状，药物成瘾，炎性疾病或生殖问题。 本发明提供的新化合物是下式的化合物：其中R1，R3，R4，R5，Z，Y，V，X，X'，J，K，L和M如本文所定义。
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公开(公告)号：US06448261B1
公开(公告)日：2002-09-10
申请号：US09525619
申请日：2000-03-14
申请人： Rajagopal Bakthavatchalam , Argyrios Georgios Arvanitis , James Peter Beck , Gary Avonn Cain , Robert John Chorvat , Paul Joseph Gilligan , Richard Eric Olson
发明人： Rajagopal Bakthavatchalam , Argyrios Georgios Arvanitis , James Peter Beck , Gary Avonn Cain , Robert John Chorvat , Paul Joseph Gilligan , Richard Eric Olson
IPC分类号： A61K3144
CPC分类号： C07D471/04 , C07D487/04 , C07D513/04
摘要： Corticotropin releasing factor (CRF) antagonists of formula I; and their use in treating anxiety, depression, and other psychiatric and neurological disorders.
摘要翻译： 式I的促肾上腺皮质激素释放因子（CRF）拮抗剂;以及它们在治疗焦虑，抑郁和其他精神和神经障碍中的用途。
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公开(公告)号：US6107300A
公开(公告)日：2000-08-22
申请号：US823029
申请日：1997-03-21
申请人： Rajagopal Bakthavatchalam , Argyrios Georgios Arvanitis , James Peter Beck , Gary Avonn Cain , Robert John Chorvat , Paul Joseph Gilligan , Richard Eric Olson
发明人： Rajagopal Bakthavatchalam , Argyrios Georgios Arvanitis , James Peter Beck , Gary Avonn Cain , Robert John Chorvat , Paul Joseph Gilligan , Richard Eric Olson
IPC分类号： C07D473/34 , A01N43/54 , A61K31/437 , A61K31/44 , A61K31/505 , A61K31/519 , A61K31/52 , A61P1/00 , A61P15/00 , A61P25/00 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , A61P29/00 , A61P37/06 , A61P43/00 , C07D221/00 , C07D239/00 , C07D471/02 , C07D471/04 , C07D487/04 , C07D513/04
CPC分类号： C07D471/04 , C07D487/04 , C07D513/04
摘要： Corticotropin releasing factor (CRF) antagonists of formula I or formula II: ##STR1## and their use in treating anxiety, depression, and other psychiatric and neurological disorders.
摘要翻译： 式I或式II的促肾上腺皮质激素释放因子（CRF）拮抗剂及其用于治疗焦虑，抑郁和其他精神和神经障碍的用途。
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公开(公告)号：US6124289A
公开(公告)日：2000-09-26
申请号：US899242
申请日：1997-07-23
IPC分类号： A61K20060101 , A61K31/505 , C07D20060101 , C07D487/04 , C07H20060101
CPC分类号： C07D487/04
摘要： Corticotropin releasing factor (CRF) antagonists of formula I or II: ##STR1## and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivityassociated with psychopathological disturbance andstress.
摘要翻译： 式I或II的促肾上腺皮质激素释放因子（CRF）拮抗剂及其用于治疗焦虑，抑郁和其他精神病学，神经障碍以及治疗与精神病理学障碍和应激相关的免疫学，心血管或心脏相关疾病和结肠超敏反应的用途。
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公开(公告)号：US07094782B1
公开(公告)日：2006-08-22
申请号：US10703235
申请日：2003-11-07
IPC分类号： A61K31/53 , C07D487/04 , C07D251/72
CPC分类号： A61K31/53 , C07D487/04
摘要： Corticotropin releasing factor (CRF) antagonists of formula I or II: and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.
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公开(公告)号：US6159980A
公开(公告)日：2000-12-12
申请号：US929935
申请日：1997-09-15
IPC分类号： A61K31/495 , A61K31/497 , A61K31/53 , A61P25/00 , A61P25/22 , A61P25/24 , A61P25/28 , C07D241/18 , C07D241/20 , C07D253/07 , C07D401/12 , C07D405/12
CPC分类号： C07D241/20 , C07D241/18 , C07D253/07 , C07D401/12 , C07D405/12
摘要： Corticotropin releasing factor (CRF) antagonists of Formula (I) ##STR1## and their use in treating psychiatric disorders and neurological diseases including major depression, anxiety-related disorders, post-traumatic stress disorders, supranuclear palsy and eating disorders.
摘要翻译： 式（I）的促肾上腺皮质激素释放因子（CRF）拮抗剂及其在治疗精神疾病和神经系统疾病中的用途，包括主要抑郁症，焦虑相关疾病，创伤后应激障碍，核上性麻痹和进食障碍。
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公开(公告)号：US06218391B1
公开(公告)日：2001-04-17
申请号：US09375048
申请日：1999-08-16
IPC分类号： C07D25307
CPC分类号： C07D241/20 , C07D241/18 , C07D253/07 , C07D401/12 , C07D405/12
摘要： Corticotropin releasing factor (CRF) antagonists of Formula (I) and their use in treating psychiatric disorders and neurological diseases including major depression, anxiety-related disorders, post-traumatic stress disorders, supranuclear palsy and eating disorders.
摘要翻译： 式（I）的促肾上腺皮质激素释放因子（CRF）拮抗剂及其在治疗精神疾病和神经疾病中的用途，包括主要抑郁症，焦虑相关疾病，创伤后应激障碍，核上性麻痹和进食障碍。
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公开(公告)号：US06313124B1
公开(公告)日：2001-11-06
申请号：US09014734
申请日：1998-01-28
IPC分类号： A61K31535
CPC分类号： A61K31/53 , C07D487/04
摘要： Corticotropin releasing factor (CRF) antagonists of formula I or II: and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.
摘要翻译： 式I或II的促肾上腺皮质激素释放因子（CRF）拮抗剂及其用于治疗焦虑，抑郁和其他精神疾病，神经障碍以及治疗与精神病理学障碍和应激相关的免疫学，心血管或心脏相关疾病和结肠超敏反应的用途 。
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公开(公告)号：US06191131B1
公开(公告)日：2001-02-20
申请号：US09015002
申请日：1998-01-28
IPC分类号： C07D48704
CPC分类号： C07D487/04
摘要： Corticotropin releasing factor (CRF) antagonists of formula I or II: and their use in treating anxiety, depression, and other psychiatric, neurological disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress.
摘要翻译： 式I或II的促肾上腺皮质激素释放因子（CRF）拮抗剂及其用于治疗焦虑，抑郁和其他精神疾病，神经障碍以及治疗与精神病理学障碍和应激相关的免疫学，心血管或心脏相关疾病和结肠超敏反应的用途 。
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