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公开(公告)号：US06852750B2
公开(公告)日：2005-02-08
申请号：US10176046
申请日：2002-06-21
IPC分类号： A61P13/08 , A61P21/00 , A61P27/06 , C07C63/307 , C07C63/68 , C07C65/05 , C07C65/40 , C07C229/38 , C07C229/60 , C07C235/80 , C07C259/06 , C07C259/10 , C07C317/44 , C07C323/12 , C07C323/56 , C07C323/62 , C07D231/06 , C07D307/52 , C07F9/38 , A61K31/415 , A61K31/341 , C07D307/34
CPC分类号： C07D231/06 , C07C63/307 , C07C63/68 , C07C65/05 , C07C65/40 , C07C229/38 , C07C229/60 , C07C235/80 , C07C259/06 , C07C259/10 , C07C317/44 , C07C323/12 , C07C323/56 , C07C323/62 , C07D307/52 , C07F9/3834 , C07F9/3882
摘要： New benzenedicarboxylic acid derivative compounds; pharmaceutical compositions, diagnostic methods, and diagnostic kits that include those compounds; and methods of using those compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-β activity, inhibiting angiogenesis, and treating glutamate abnormalities, neuropathy, pain, compulsive disorders, prostate diseases, cancers, and glaucoma.
摘要翻译： 新型苯二甲酸衍生物化合物; 包括那些化合物的药物组合物，诊断方法和诊断试剂盒; 以及使用这些化合物抑制NAALADase酶活性的方法，检测NAALADase水平改变，影响神经元活性，影响TGF-β活性，抑制血管发生，治疗谷氨酸异常，神经病，疼痛，强迫症，前列腺疾病，癌症等疾病， 和青光眼。
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公开(公告)号：US06452044B2
公开(公告)日：2002-09-17
申请号：US09866758
申请日：2001-05-30
IPC分类号： C07C32110
CPC分类号： C07D231/06 , C07C63/307 , C07C63/68 , C07C65/05 , C07C65/40 , C07C229/38 , C07C229/60 , C07C235/80 , C07C259/06 , C07C259/10 , C07C317/44 , C07C323/12 , C07C323/56 , C07C323/62 , C07D307/52 , C07F9/3834 , C07F9/3882
摘要： New benzenedicarboxylic acid derivative compounds; pharmaceutical compositions, diagnostic methods, and diagnstic kits that include those compounds; and methods of using those compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-&bgr; activity, inhibiting angiogenesis, and treating glutamate abnormalities, neutopathy, pain, compulsive disorders, prostate diseases, cancers, and glaucoma.
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公开(公告)号：US6071965A
公开(公告)日：2000-06-06
申请号：US2147
申请日：1997-12-31
申请人： Paul F. Jackson , Weixing Li , Keith M. Maclin , Kevin L. Tays , Takashi Tsukamoto , Barbara S. Slusher
发明人： Paul F. Jackson , Weixing Li , Keith M. Maclin , Kevin L. Tays , Takashi Tsukamoto , Barbara S. Slusher
IPC分类号： A61K31/00 , A61K31/194 , A61K31/66 , A61K31/665 , A61K31/67 , A61K31/675 , A61K38/05 , A61K38/06 , C07F9/30 , C07F9/32 , C07F9/38 , C07F9/40 , C07F9/44 , C07F9/58 , C07F9/655 , C07F9/6553 , C12N9/99 , C07F9/28
CPC分类号： C07F9/582 , A61K31/00 , A61K31/194 , A61K31/66 , A61K31/661 , A61K31/662 , A61K31/664 , A61K31/665 , A61K31/67 , A61K31/675 , A61K38/05 , A61K38/06 , C07F9/301 , C07F9/3211 , C07F9/3808 , C07F9/3826 , C07F9/4075 , C07F9/4465 , C07F9/65515 , C07F9/6552 , C07F9/655345
摘要： The present invention relate to phosphinic alkanoic acid derivatives that inhibit N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising the same, and methods of using the same to inhibit NAALADase activity and to treat glutamate abnormalities and prostate diseases.
摘要翻译： 本发明涉及抑制N-乙酰化的α-酸性二酸二肽酶（NAALADase）酶活性的次膦酸链烷酸衍生物，含有它们的药物组合物及其使用方法抑制NAALADase活性和治疗谷氨酸异常和前列腺疾病。
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公开(公告)号：US6121252A
公开(公告)日：2000-09-19
申请号：US50009
申请日：1998-03-30
IPC分类号： A61K31/662 , A61K31/675 , A61P13/08 , A61P25/00 , A61P25/16 , A61P25/28 , A61P25/30 , A61P35/00 , A61P43/00 , C07F9/30 , C07F9/40 , C07F9/44 , C07F9/553 , C07F9/02 , C07F9/22
CPC分类号： C07F9/5537 , C07F9/301
摘要： The present invention relate to phosphinic acid derivatives that inhibit N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising the same, and methods of using the same to inhibit NAALADase activity and to treat glutamate abnormalities and prostate diseases.
摘要翻译： 本发明涉及抑制N-乙酰化的α-酸性二酸二肽酶（NAALADase）酶活性的次膦酸衍生物，含有它们的药物组合物及其用途，以抑制NAALADase活性和治疗谷氨酸异常和前列腺疾病。
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公开(公告)号：US06992215B2
公开(公告)日：2006-01-31
申请号：US10959199
申请日：2004-10-07
IPC分类号： C07C321/06 , C07C323/04 , C07C317/14 , A61K31/095
CPC分类号： C07C323/56 , C07C323/52 , C07C323/58 , C07C323/59 , C07C323/60 , C07C323/62 , C07C323/65
摘要： This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-β activity, inhibiting angiogenesis, and treating glutamate abnormalities, diabetic neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.
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公开(公告)号：US06812364B2
公开(公告)日：2004-11-02
申请号：US10431462
申请日：2003-05-08
IPC分类号： C07C32106
CPC分类号： C07C323/56 , C07C323/52 , C07C323/58 , C07C323/59 , C07C323/60 , C07C323/62 , C07C323/65
摘要： This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-&bgr; activity, inhibiting angiogenesis, and treating glutamate abnormalities, diabetic neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.
摘要翻译： 本发明涉及包含这些化合物的新化合物，药物组合物和诊断试剂盒，以及使用这些化合物抑制NAALADase酶活性的方法，检测NAALADase水平改变，影响神经元活性，影响TGF-β活性，抑制血管生成的疾病，以及 治疗谷氨酸异常，糖尿病性神经病，疼痛，强迫症，前列腺疾病，癌症和青光眼。
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公开(公告)号：US07968593B2
公开(公告)日：2011-06-28
申请号：US12472251
申请日：2009-05-26
IPC分类号： A61K31/382 , A61K31/381 , C07D335/06 , C07D335/04
CPC分类号： C07D335/02 , C07D335/06
摘要： This invention provides new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, inhibiting angiogenesis, effecting a TGF-β activity or a neuronal activity, and treating a glutamate abnormality, a compulsive disorder, neuropathy, pain, a prostate disease, cancer, Huntington's disease, diabetes, a retinal disorder or glaucoma.
摘要翻译： 本发明提供新的化合物，药物组合物和包含这些化合物的诊断试剂，以及使用这些化合物抑制NAALADase酶活性的方法，检测NAALADase水平被改变的疾病，抑制血管发生，影响TGF- 活动或神经元活动，以及治疗谷氨酸异常，强迫症，神经病，疼痛，前列腺疾病，癌症，亨廷顿氏病，糖尿病，视网膜病症或青光眼。
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公开(公告)号：US07125907B2
公开(公告)日：2006-10-24
申请号：US10791278
申请日：2004-03-03
IPC分类号： C07D335/02 , A61K31/382
CPC分类号： C07D335/02 , C07D335/06
摘要： This invention provides new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, inhibiting angiogenesis, effecting a TGF-β activity or a neuronal activity, and treating a glutamate abnormality, a compulsive disorder, neuropathy, pain, a prostate disease, cancer, Huntington's disease, diabetes, a retinal disorder or glaucoma.
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公开(公告)号：US06586623B2
公开(公告)日：2003-07-01
申请号：US10046917
申请日：2002-01-17
IPC分类号： C07C32106
CPC分类号： C07C323/56 , C07C323/52 , C07C323/58 , C07C323/59 , C07C323/60 , C07C323/62 , C07C323/65
摘要： This invention relates to new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-&bgr; activity, inhibiting angiogenesis, and treating glutamate abnormalities, diabetic neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.
摘要翻译： 本发明涉及包含这些化合物的新化合物，药物组合物和诊断试剂盒，以及使用这些化合物抑制NAALADase酶活性的方法，检测NAALADase水平改变，影响神经元活性，影响TGF-β活性，抑制血管生成的疾病，以及 治疗谷氨酸异常，糖尿病性神经病，疼痛，强迫症，前列腺疾病，癌症和青光眼。
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公开(公告)号：US07553866B2
公开(公告)日：2009-06-30
申请号：US11830737
申请日：2007-07-30
IPC分类号： A61K31/38 , A61K31/382 , C07D335/02
CPC分类号： C07D335/02 , C07D335/06
摘要： This invention provides new compounds, pharmaceutical compositions and diagnostic kits comprising such compounds, and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, inhibiting angiogenesis, effecting a TGF-β activity or a neuronal activity, and treating a glutamate abnormality, a compulsive disorder, neuropathy, pain, a prostate disease, cancer, Huntington's disease, diabetes, a retinal disorder or glaucoma.
摘要翻译： 本发明提供新的化合物，药物组合物和包含这些化合物的诊断试剂，以及使用这些化合物抑制NAALADase酶活性的方法，检测NAALADase水平被改变的疾病，抑制血管发生，影响TGF-β活性或神经元活性，以及 治疗谷氨酸异常，强迫症，神经病，疼痛，前列腺疾病，癌症，亨廷顿氏病，糖尿病，视网膜病症或青光眼。
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