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公开(公告)号:US09211250B2
公开(公告)日:2015-12-15
申请号:US13059946
申请日:2009-05-13
申请人: Paul Johnson , Patrick S. Stayton , Allan S. Hoffman , Robert Overell , Anna Gall , Mary Prieve , Amber Paschal , Charbel Diab , Priyadarsi De
发明人: Paul Johnson , Patrick S. Stayton , Allan S. Hoffman , Robert Overell , Anna Gall , Mary Prieve , Amber Paschal , Charbel Diab , Priyadarsi De
CPC分类号: A61K9/0019 , A61K9/1075 , A61K47/58 , C08L53/00 , C12N15/88 , C08L2666/24
摘要: Compositions comprising a heterogeneous polymeric micelle and an agent (e.g., a polynucleotide) associated with the micelle are disclosed, together with methods for intracellular delivery of such agent.
摘要翻译: 公开了包含非均相聚合物胶束和与胶束相关的试剂(例如,多核苷酸)的组合物,以及用于细胞内递送该试剂的方法。
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公开(公告)号:US20120021514A1
公开(公告)日:2012-01-26
申请号:US13059946
申请日:2009-05-13
申请人: Paul Johnson , Patrick S. Stayton , Allan S. Hoffman , Robert Overell , Anna Gall , Mary Prieve , Amber Paschal , Charbel Diab , Priyadarsi De
发明人: Paul Johnson , Patrick S. Stayton , Allan S. Hoffman , Robert Overell , Anna Gall , Mary Prieve , Amber Paschal , Charbel Diab , Priyadarsi De
CPC分类号: A61K9/0019 , A61K9/1075 , A61K47/58 , C08L53/00 , C12N15/88 , C08L2666/24
摘要: Compositions comprising a heterogeneous polymeric micelle and an agent (e.g., a polynucleotide) associated with the micelle are disclosed, together with methods for intracellular delivery of such agent.
摘要翻译: 公开了包含非均相聚合物胶束和与胶束相关的试剂(例如,多核苷酸)的组合物,以及用于细胞内递送该试剂的方法。
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3.
公开(公告)号:US20110281934A1
公开(公告)日:2011-11-17
申请号:US13127962
申请日:2009-05-13
申请人: Paul Johnson , Patrick S. Stayton , Allan S. Hoffman , Robert Overell , Anna Gall , Mary Prieve , Amber Paschal , Charbel Diab , Priyadarsi De
发明人: Paul Johnson , Patrick S. Stayton , Allan S. Hoffman , Robert Overell , Anna Gall , Mary Prieve , Amber Paschal , Charbel Diab , Priyadarsi De
IPC分类号: A61K31/713 , C08F271/02 , C08F265/04
CPC分类号: A61K9/1075 , A61K47/549 , A61K47/58 , A61K47/60 , A61K47/6907
摘要: Provided herein are micelles comprising a plurality of copolymers. In certain instances, micelles provided herein are pH sensitive particles.
摘要翻译: 本文提供了包含多种共聚物的胶束。 在某些情况下,本文提供的胶束是pH敏感颗粒。
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