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公开(公告)号：US08765169B2
公开(公告)日：2014-07-01
申请号：US10589150
申请日：2005-02-14
申请人： Paul Kemp , Györgyi Talas , Jennifer Sutherland , Margaret Batten , Penelope Ann Johnson , Andrew Shering , Michael McWhan
发明人： Paul Kemp , Györgyi Talas , Jennifer Sutherland , Margaret Batten , Penelope Ann Johnson , Andrew Shering , Michael McWhan
CPC分类号： A61K35/33 , A61K35/34 , A61K35/36 , A61K45/06 , A61L27/3804 , A61L27/3895 , A61L27/60 , G01N33/56966 , A61K2300/00
摘要： The present invention relates to compositions and methods for tissue regeneration, particularly for treating skin lesions such as wounds. In one aspect, the invention provides wound healing composition characterized by the higher expression levels of phenotypic marker genes such as apolipoprotein D, matrix metalloprotease (2), collagen 3a1 and smooth muscle actin than the housekeeping gene ribosomal protein L32. The compositions and methods of the invention are useful especially for assisting the process of wound healing, particularly chronic open lesions that are slow to heal or resistant to healing.
摘要翻译： 本发明涉及用于组织再生的组合物和方法，特别是用于治疗皮肤损伤如伤口。 一方面，本发明提供伤口愈合组合物，其特征在于表型标记基因如载脂蛋白D，基质金属蛋白酶（2），胶原蛋白3a1和平滑肌肌动蛋白的表达水平高于持家基因核糖体蛋白L32。 本发明的组合物和方法特别适用于辅助伤口愈合过程，特别是慢愈合或抗愈合的慢性开放病变。
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公开(公告)号：US09526746B2
公开(公告)日：2016-12-27
申请号：US10589227
申请日：2005-02-14
申请人： Paul Kemp , Györgyi Talas , Jennifer Sutherland , Margaret Batten , Penelope Ann Johnson , Andrew Shering , Michael McWhan
发明人： Paul Kemp , Györgyi Talas , Jennifer Sutherland , Margaret Batten , Penelope Ann Johnson , Andrew Shering , Michael McWhan
IPC分类号： A61K35/12 , A61K9/00 , A61P17/02 , A61K35/33 , A61K35/34 , A61K35/36 , A61L27/38 , A61L27/60 , G01N33/569 , A61K45/06
CPC分类号： A61K35/33 , A61K35/34 , A61K35/36 , A61K45/06 , A61L27/3804 , A61L27/3895 , A61L27/60 , G01N33/56966 , A61K2300/00
摘要： The present invention relates to compositions and methods for tissue regeneration, particularly for treating skin lesions such as wounds. In one aspect, the invention provides a wound healing composition comprising living cells such as fibroblasts within a support matrix such as fibrin, in which the cells have a wound healing phenotype, and in which the composition is single layered and has been incubated for up to about 8 days to allow development of the wound healing phenotype. The compositions and methods of the invention are useful especially for assisting the process of wound healing, particularly chronic open lesions that are slow to heal or resistant to healing.
摘要翻译： 本发明涉及用于组织再生的组合物和方法，特别是用于治疗皮肤损伤如伤口。 在一个方面，本发明提供一种伤口愈合组合物，其包含活细胞，例如载体基质如纤维蛋白中的成纤维细胞，其中细胞具有伤口愈合表型，并且其中组合物是单层的并且已经孵育达 约8天允许发展伤口愈合表型。 本发明的组合物和方法特别适用于辅助伤口愈合过程，特别是慢愈合或抗愈合的慢性开放性病变。
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公开(公告)号：US20080226720A1
公开(公告)日：2008-09-18
申请号：US10589227
申请日：2005-02-14
申请人： Paul Kemp , Gyorgyi Talas , Jennifer Sutherland , Margaret Batten , Penelope Ann Johnson , Andrew Shering , Michael McWhan
发明人： Paul Kemp , Gyorgyi Talas , Jennifer Sutherland , Margaret Batten , Penelope Ann Johnson , Andrew Shering , Michael McWhan
CPC分类号： A61K35/33 , A61K35/34 , A61K35/36 , A61K45/06 , A61L27/3804 , A61L27/3895 , A61L27/60 , G01N33/56966 , A61K2300/00
摘要： The present invention relates to compositions and methods for tissue regeneration, particularly for treating skin lesions such as wounds. In one aspect, the invention provides a wound healing composition comprising living cells such as fibroblasts within a support matrix such as fibrin, in which the cells have a wound healing phenotype, and in which the composition is single layered and has been incubated for up to about 8 days to allow development of the wound healing phenotype. The compositions and methods of the invention are useful especially for assisting the process of wound healing, particularly chronic open lesions that are slow to heal or resistant to healing.
摘要翻译： 本发明涉及用于组织再生的组合物和方法，特别是用于治疗皮肤损伤如伤口。 在一个方面，本发明提供一种伤口愈合组合物，其包含活细胞，例如载体基质如纤维蛋白中的成纤维细胞，其中细胞具有伤口愈合表型，并且其中组合物是单层的并且已经孵育达 约8天允许发展伤口愈合表型。 本发明的组合物和方法特别适用于辅助伤口愈合过程，特别是慢愈合或抗愈合的慢性开放病变。
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公开(公告)号：US20080193507A1
公开(公告)日：2008-08-14
申请号：US10589150
申请日：2005-02-14
申请人： Paul Kemp , Gyorgyi Talas , Jennifer Sutherland , Margaret Batten , Penelope Ann Johnson , Andrew Shering , Michael McWhan
发明人： Paul Kemp , Gyorgyi Talas , Jennifer Sutherland , Margaret Batten , Penelope Ann Johnson , Andrew Shering , Michael McWhan
CPC分类号： A61K35/33 , A61K35/34 , A61K35/36 , A61K45/06 , A61L27/3804 , A61L27/3895 , A61L27/60 , G01N33/56966 , A61K2300/00
摘要： The present invention relates to compositions and methods for tissue regeneration, particularly for treating skin lesions such as wounds. In one aspect, the invention provides wound healing composition characterised by the higher expression levels of phenotypic marker genes such as apolipoprotein D, matrix metalloprotease (2), collagen 3a1 and smooth muscle actin than the housekeeping gene ribosomal protein L32. The compositions and methods of the invention are useful especially for assisting the process of wound healing, particularly chronic open lesions that are slow to heal or resistant to healing.
摘要翻译： 本发明涉及用于组织再生的组合物和方法，特别是用于治疗皮肤损伤如伤口。 一方面，本发明提供伤口愈合组合物，其特征在于表型标记基因如载脂蛋白D，基质金属蛋白酶（2），胶原蛋白3a1和平滑肌肌动蛋白的表达水平高于持家基因核糖体蛋白L32。 本发明的组合物和方法特别适用于辅助伤口愈合过程，特别是慢愈合或抗愈合的慢性开放病变。
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