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    Application of a therapeutic substance to a tissue location using an expandable medical device
    8.
    发明授权
    Application of a therapeutic substance to a tissue location using an expandable medical device 有权
    使用可扩张医疗装置将治疗物质施用于组织位置

    公开(公告)号：US07572245B2

    公开(公告)日：2009-08-11

    申请号：US10942764

    申请日：2004-09-15

    申请人： Steve A. Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton

    发明人： Steve A. Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton

    IPC分类号： A61M31/00

    CPC分类号： A61L29/16 ,  A61L31/16 ,  A61L2300/606

    摘要： A non-polymeric or biological coating applied to radially expandable interventional medical devices provides uniform drug distribution and permeation of the coating and any therapeutic agents mixed therewith into a targeted treatment area within the body. The coating is sterile, and is capable of being carried by a sterile medical device to a targeted tissue location within the body following radial expansion. The therapeutic coating transfers off the medical device due in part to a biological attraction with the tissue and in part to a physical transference from the medical device to the targeted tissue location in contact with the medical device. Thus, atraumatic local tissue transference delivery is achieved for uniform therapeutic agent distribution and controlled bio-absorption into the tissue after placement within a patient's body with a non-inflammatory coating.

    摘要翻译： 施加到可径向扩张的介入医疗装置的非聚合或生物涂层提供了涂层和与其混合的任何治疗剂的均匀的药物分布和渗透到体内的目标治疗区域。 涂层是无菌的，并且能够在径向膨胀后由无菌医疗装置携带到身体内的目标组织位置。 治疗涂层部分地由于与组织的生物吸引而部分地转移离开医疗装置，并且部分地从医疗装置到与医疗装置接触的目标组织位置的物理转移。 因此，在用非炎性涂层放置在患者体内之后，实现了不均匀的局部组织转移递送，用于均匀的治疗剂分布和对组织的受控生物吸收。

    Method for treating expandable polymer materials
    9.
    发明授权
    Method for treating expandable polymer materials 有权
    处理可膨胀聚合物材料的方法

    公开(公告)号：US06890463B2

    公开(公告)日：2005-05-10

    申请号：US10131446

    申请日：2002-04-22

    申请人： Paul Martakos ,  Roger Labrecque ,  Geoffrey Moodie ,  Steve A. Herweck ,  Theodore Karwoski

    发明人： Paul Martakos ,  Roger Labrecque ,  Geoffrey Moodie ,  Steve A. Herweck ,  Theodore Karwoski

    IPC分类号： A61F2/06 ,  B29B11/10 ,  B29B11/14 ,  B29B13/00 ,  B29B13/02 ,  B29B15/00

    CPC分类号： A61F2/06

    摘要： The invention is directed to methods involving rewetting of expandable polymers with a wettable liquid to allow for enhanced expansion at or below room temperature without breakage, and in some cases, allows one to achieve a greater expansion ratio than that allowed at elevated temperatures using known methods. The wettable liquid can be formed of a drug and/or an agent, such that the resulting polymer contains and emits the drug upon positioning at a target location of a patient body. The present invention also allows one to achieve material with unique properties and handling characteristics. These properties included decreased material thickness, increased density, an altered node/fibril morphology, and a more consistent web in the case of flat material. This method is not limited to room temperature conditions and can be applied whenever the expandable polymer material is wet with a wettable liquid, and the expansion is performed at a temperature preferably below the vaporization or boiling points of that liquid.

    摘要翻译： 本发明涉及包括用可湿性液体再湿润可膨胀聚合物以允许在室温或低于室温下增强膨胀而不破裂的方法，并且在某些情况下允许使用已知方法获得比在升高的温度下更大的膨胀比 。 可湿性液体可以由药物和/或药剂形成，使得所得聚合物在定位在患者身体的目标位置时含有和释放药物。 本发明还可以实现具有独特性质和处理特性的材料。 这些性质包括材料厚度减小，密度增加，节点/原纤维形态改变，以及在平坦材料情况下更一致的网。 该方法不限于室温条件，只要可膨胀聚合物材料用可湿性液体润湿，并且膨胀在优选低于该液体的蒸发或沸点的温度下进行。