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公开(公告)号：US20120315219A1
公开(公告)日：2012-12-13
申请号：US13593656
申请日：2012-08-24
申请人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck
发明人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck
IPC分类号： A61K9/00 , A61P29/00 , A61P7/02 , A61P3/00 , A61P35/00 , A61K49/00 , A61K38/14 , A61K31/727 , A61K31/44 , A61K31/4709 , A61K31/405 , A61K31/366 , A61K31/337 , A61K31/215 , A61K31/4353 , B05D3/00 , B05D5/00 , A61K31/7088
CPC分类号： A61L31/08 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61K47/10 , A61K47/22 , A61K47/44 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/22 , A61L2300/416 , A61L2300/428 , A61L2300/45 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M25/0009 , A61M25/0045
摘要： A coated medical device and a method of providing a coating on an implantable medical device result in a medical device having a bio-absorbable coating. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component can also be provided. The coated medical device is implantable in a patient to effect controlled delivery of the coating, including the therapeutic agent, to the patient.
摘要翻译： 涂覆的医疗装置和在可植入医疗装置上提供涂层的方法导致具有生物可吸收涂层的医疗装置。 涂层包括生物吸收载体组分。 除了生物可吸收载体组分之外，还可以提供治疗剂成分。 涂覆的医疗装置可植入患者体内以实现对包括治疗剂在内的涂层的可控输送。
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公开(公告)号：US08001922B2
公开(公告)日：2011-08-23
申请号：US11238554
申请日：2005-09-28
申请人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Suzanne Conroy , Brian Sunter , Georgette Henrich
发明人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Suzanne Conroy , Brian Sunter , Georgette Henrich
IPC分类号： B05C1/00
CPC分类号： A61L31/08 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61K47/10 , A61K47/22 , A61K47/44 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/22 , A61L2300/416 , A61L2300/428 , A61L2300/45 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M25/0009 , A61M25/0045
摘要： Devices for the provision of a coating on an implantable medical device are provided. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component can also be provided. The devices provide a coating having improved uniformity and coverage which in turn allow for greater control of the amount and dosage of the coating.
摘要翻译： 提供了用于在可植入医疗装置上提供涂层的装置。 涂层包括生物吸收载体组分。 除了生物可吸收载体组分之外，还可以提供治疗剂成分。 这些装置提供具有改进的均匀性和覆盖度的涂层，这又允许更大程度地控制涂层的量和剂量。
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公开(公告)号：US08722077B2
公开(公告)日：2014-05-13
申请号：US13593656
申请日：2012-08-24
申请人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck
发明人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck
CPC分类号： A61L31/08 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61K47/10 , A61K47/22 , A61K47/44 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/22 , A61L2300/416 , A61L2300/428 , A61L2300/45 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M25/0009 , A61M25/0045
摘要： A coated medical device and a method of providing a coating on an implantable medical device result in a medical device having a bio-absorbable coating. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component can also be provided. The coated medical device is implantable in a patient to effect controlled delivery of the coating, including the therapeutic agent, to the patient.
摘要翻译： 涂覆的医疗装置和在可植入医疗装置上提供涂层的方法导致具有生物可吸收涂层的医疗装置。 涂层包括生物吸收载体组分。 除了生物可吸收载体组分之外，还可以提供治疗剂成分。 涂覆的医疗装置可植入患者体内以实现对包括治疗剂在内的涂层的可控输送。
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公开(公告)号：US08263102B2
公开(公告)日：2012-09-11
申请号：US11236908
申请日：2005-09-28
申请人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck
发明人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck
CPC分类号： A61L31/08 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61K47/10 , A61K47/22 , A61K47/44 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/22 , A61L2300/416 , A61L2300/428 , A61L2300/45 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M25/0009 , A61M25/0045
摘要： A coated medical device an a method of providing a coating on an implantable medical device result in a medical device having a bio-absorbable coating. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component can also be provided. The coated medical device is implantable in a patient to effect controlled delivery of the coating, including the therapeutic agent, to the patient.
摘要翻译： 涂覆的医疗装置是在可植入医疗装置上提供涂层的方法，导致具有生物吸收性涂层的医疗装置。 涂层包括生物吸收载体组分。 除了生物可吸收载体组分之外，还可以提供治疗剂成分。 涂覆的医疗装置可植入患者体内以实现对包括治疗剂在内的涂层的可控输送。
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公开(公告)号：US08722132B2
公开(公告)日：2014-05-13
申请号：US13185135
申请日：2011-07-18
申请人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Suzanne Conroy , Brian Sunter , Georgette Henrich
发明人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Suzanne Conroy , Brian Sunter , Georgette Henrich
IPC分类号： B05D3/00
CPC分类号： A61L31/08 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61K47/10 , A61K47/22 , A61K47/44 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/22 , A61L2300/416 , A61L2300/428 , A61L2300/45 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M25/0009 , A61M25/0045
摘要： Methods and devices for the provision of a coating on an implantable medical device. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component can also be provided. The methods and devices provide a coating having improved uniformity and coverage which in turn allow for greater control of the amount and dosage of the coating.
摘要翻译： 用于在可植入医疗装置上提供涂层的方法和装置。 涂层包括生物吸收载体组分。 除了生物可吸收载体组分之外，还可以提供治疗剂成分。 所述方法和装置提供了具有改进的均匀性和覆盖度的涂层，其又允许更大程度地控制涂层的量和剂量。
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公开(公告)号：US20110274823A1
公开(公告)日：2011-11-10
申请号：US13185135
申请日：2011-07-18
申请人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Suzanne Conroy , Brian Sunter , Georgette Henrich
发明人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Suzanne Conroy , Brian Sunter , Georgette Henrich
CPC分类号： A61L31/08 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61K47/10 , A61K47/22 , A61K47/44 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/22 , A61L2300/416 , A61L2300/428 , A61L2300/45 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M25/0009 , A61M25/0045
摘要： Methods and devices for the provision of a coating on an implantable medical device. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component can also be provided. The methods and devices provide a coating having improved uniformity and coverage which in turn allow for greater control of the amount and dosage of the coating.
摘要翻译： 用于在可植入医疗装置上提供涂层的方法和装置。 涂层包括生物吸收载体组分。 除了生物可吸收载体组分之外，还可以提供治疗剂成分。 所述方法和装置提供了具有改进的均匀性和覆盖度的涂层，其又允许更大程度地控制涂层的量和剂量。
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公开(公告)号：US08021331B2
公开(公告)日：2011-09-20
申请号：US11250768
申请日：2005-10-14
申请人： Steve A. Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton , Lisa Rogers , Joseph Ferraro
发明人： Steve A. Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton , Lisa Rogers , Joseph Ferraro
CPC分类号： B05D1/00 , A61F2/82 , A61F2/958 , A61F2250/0067 , A61L29/08 , A61L29/16 , A61L2300/606 , A61M25/1027 , A61M25/1038 , A61M2025/1031 , B05D2259/00 , Y10T29/49
摘要： A non-polymeric or biological coating applied to a radially expandable interventional medical device in a collapsed, wrapped, or folded configuration. Properties of the coating material applied to the medical device are adjusted or varied to result in a desired combination of coverage of the surface of the medical device, drug loading, and coating thickness. The coating is sterile, and is capable of being carried by a sterile medical device to a targeted tissue location within the body following radial expansion. The therapeutic coating transfers off the medical device due in part to a biological attraction with the tissue and in part to a physical transference from the medical device to the targeted tissue location in contact with the medical device.
摘要翻译： 以折叠的，包裹的或折叠的构造施加到可径向展开的介入医疗装置的非聚合或生物涂层。 调整或改变施加到医疗装置上的涂层材料的性质，以产生医疗装置的表面，药物负载和涂层厚度的覆盖范围的期望组合。 涂层是无菌的，并且能够在径向膨胀后由无菌医疗装置携带到身体内的目标组织位置。 治疗涂层部分地由于与组织的生物吸引而部分地转移离开医疗装置，并且部分地从医疗装置到与医疗装置接触的目标组织位置的物理转移。
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公开(公告)号：US08308684B2
公开(公告)日：2012-11-13
申请号：US13102876
申请日：2011-05-06
申请人： Steve A. Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton , Lisa Rogers , Joseph Ferraro
发明人： Steve A. Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton , Lisa Rogers , Joseph Ferraro
CPC分类号： B05D1/00 , A61F2/82 , A61F2/958 , A61F2250/0067 , A61L29/08 , A61L29/16 , A61L2300/606 , A61M25/1027 , A61M25/1038 , A61M2025/1031 , B05D2259/00 , Y10T29/49
摘要： A non-polymeric or biological coating applied to a radially expandable interventional medical device in a collapsed, wrapped, or folded configuration, the coating applied within at least one fold. Properties of the coating material applied to the medical device are adjusted or varied to result in a desired combination of coverage of the surface of the medical device, drug loading, and coating thickness. The coating is sterile, and is capable of being carried by a sterile medical device to a targeted tissue location within the body following radial expansion. The therapeutic coating transfers off the medical device due in part to a biological attraction with the tissue and in part to a physical transference from the medical device to the targeted tissue location in contact with the medical device.
摘要翻译： 以折叠的，包裹的或折叠的形式施加到可径向展开的介入医疗装置的非聚合物或生物涂层，所述涂层施用在至少一个折叠内。 调整或改变施加到医疗装置上的涂层材料的性质，以产生医疗装置的表面，药物负载和涂层厚度的覆盖范围的期望组合。 涂层是无菌的，并且能够在径向膨胀后由无菌医疗装置携带到身体内的目标组织位置。 治疗涂层部分地由于与组织的生物吸引而部分地转移离开医疗装置，并且部分地从医疗装置到与医疗装置接触的目标组织位置的物理转移。
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公开(公告)号：US20110213302A1
公开(公告)日：2011-09-01
申请号：US13102876
申请日：2011-05-06
申请人： Steve A. Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton , Lisa Rogers , Joseph Ferraro
发明人： Steve A. Herweck , Paul Martakos , Geoffrey Moodie , Roger Labrecque , Theodore Karwoski , Trevor Carlton , Lisa Rogers , Joseph Ferraro
CPC分类号： B05D1/00 , A61F2/82 , A61F2/958 , A61F2250/0067 , A61L29/08 , A61L29/16 , A61L2300/606 , A61M25/1027 , A61M25/1038 , A61M2025/1031 , B05D2259/00 , Y10T29/49
摘要： A non-polymeric or biological coating applied to a radially expandable interventional medical device in a collapsed, wrapped, or folded configuration, the coating applied within at least one fold. Properties of the coating material applied to the medical device are adjusted or varied to result in a desired combination of coverage of the surface of the medical device, drug loading, and coating thickness. The coating is sterile, and is capable of being carried by a sterile medical device to a targeted tissue location within the body following radial expansion. The therapeutic coating transfers off the medical device due in part to a biological attraction with the tissue and in part to a physical transference from the medical device to the targeted tissue location in contact with the medical device.
摘要翻译： 以折叠的，包裹的或折叠的形式施加到可径向展开的介入医疗装置的非聚合物或生物涂层，所述涂层施用在至少一个折叠内。 调整或改变施加到医疗装置上的涂层材料的性质，以产生医疗装置的表面，药物负载和涂层厚度的覆盖范围的期望组合。 涂层是无菌的，并且能够在径向膨胀后由无菌医疗装置携带到身体内的目标组织位置。 治疗涂层部分地由于与组织的生物吸引而部分地转移离开医疗装置，并且部分地从医疗装置到与医疗装置接触的目标组织位置的物理转移。
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公开(公告)号：US20140308333A1
公开(公告)日：2014-10-16
申请号：US14252671
申请日：2014-04-14
申请人： Roger Labrecque , Geoffrey Moodie , Joseph F. Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck
发明人： Roger Labrecque , Geoffrey Moodie , Joseph F. Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck
CPC分类号： A61L31/08 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61K47/10 , A61K47/22 , A61K47/44 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/22 , A61L2300/416 , A61L2300/428 , A61L2300/45 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M25/0009 , A61M25/0045
摘要： A coating material including a bio-absorbable cross-linked material and a cellular uptake inhibitor. The bio-absorbable cross-linked material includes two or more fatty acids cross-linked into a substantially random configuration by ester bonds. The coating material may be adhered to a medical device. A medical device system including a medical device and a coating is also included.
摘要翻译： 包括生物可吸收交联材料和细胞吸收抑制剂的涂层材料。 生物可吸收交联材料包括通过酯键交联成基本上无规构型的两种或更多种脂肪酸。 涂层材料可以粘附到医疗装置。 还包括包括医疗装置和涂层的医疗装置系统。
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