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公开(公告)号:US07309491B2
公开(公告)日:2007-12-18
申请号:US10820067
申请日:2004-04-08
申请人: Paul Slusarewicz , Jessica Baker Flechtner , Sunil Mehta , Kenya Prince-Cohane , Sofija Andjelic , Brian H. Barber
发明人: Paul Slusarewicz , Jessica Baker Flechtner , Sunil Mehta , Kenya Prince-Cohane , Sofija Andjelic , Brian H. Barber
IPC分类号: A61K39/385 , A61K39/00 , A61K39/29
CPC分类号: C07K14/005 , A61K39/0011 , A61K39/385 , A61K2039/545 , A61K2039/6043 , A61K2039/622 , A61K2039/627 , C07K14/4748 , C07K2319/70 , C12N2710/20022 , C12N2760/20222 , Y02A50/414
摘要: Hybrid antigens comprising at least one antigenic domain, at least one heat shock protein binding domain, and at least one improved peptide linker there between are described which are useful for the induction of an immune response to the antigenic domain when administered alone or in a complex with at least one heat shock protein. The hybrid antigens and complexes can be used to treat infectious diseases and cancers that express an antigen of the antigenic domain.
摘要翻译: 描述了包含至少一个抗原结构域,至少一个热休克蛋白结合结构域和其间至少一个改进的肽接头的杂合抗原,其可用于当单独施用或在复合物中诱导针对抗原结构域的免疫应答时 与至少一个热休克蛋白。 杂交抗原和复合物可用于治疗表达抗原结构域抗原的传染病和癌症。
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公开(公告)号:US20050214312A1
公开(公告)日:2005-09-29
申请号:US10820067
申请日:2004-04-08
申请人: Jessica Flechtner , Kenya Prince-Cohane , Sunil Mehta , Paul Slusarewicz , Sofija Andjelic , Brian Barber
发明人: Jessica Flechtner , Kenya Prince-Cohane , Sunil Mehta , Paul Slusarewicz , Sofija Andjelic , Brian Barber
IPC分类号: A61K39/00 , A61K39/385 , C07K14/025 , C07K14/145 , C07K14/47
CPC分类号: C07K14/005 , A61K39/0011 , A61K39/385 , A61K2039/545 , A61K2039/6043 , A61K2039/622 , A61K2039/627 , C07K14/4748 , C07K2319/70 , C12N2710/20022 , C12N2760/20222 , Y02A50/414
摘要: Hybrid antigens comprising at least one antigenic domain, at least one heat shock protein binding domain, and at least one improved peptide linker there between are described which are useful for the induction of an immune response to the antigenic domain when administered alone or in a complex with at least one heat shock protein. The hybrid antigens and complexes can be used to treat infectious diseases and cancers that express an antigen of the antigenic domain.
摘要翻译: 描述了包含至少一个抗原结构域,至少一个热休克蛋白结合结构域和其间至少一个改进的肽接头的杂合抗原,其可用于当单独施用或在复合物中诱导针对抗原结构域的免疫应答时 与至少一个热休克蛋白。 杂交抗原和复合物可用于治疗表达抗原结构域抗原的传染病和癌症。
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公开(公告)号:US20050202033A1
公开(公告)日:2005-09-15
申请号:US10776521
申请日:2004-02-12
申请人: Jessica Flechtner , Kenya Prince-Cohane , Sunil Mehta , Paul Slusarewicz , Sofija Andjelic , Brian Barber
发明人: Jessica Flechtner , Kenya Prince-Cohane , Sunil Mehta , Paul Slusarewicz , Sofija Andjelic , Brian Barber
IPC分类号: A61K20060101 , A61K38/08 , A61K38/17 , A61K39/00 , A61K39/385 , A61K47/48 , A61P35/00 , C07K7/06 , C07K14/47 , C07K14/82 , C07K19/00
CPC分类号: B82Y5/00 , A61K39/0011 , A61K39/385 , A61K47/646 , A61K47/66 , A61K2039/6043 , A61K2039/622 , C07K2319/20 , Y02A50/414
摘要: Hybrid antigens comprising an antigenic domain and improved heat shock protein binding domains are described which are useful for the induction of an immune response to the antigenic domain and thus can be used to treat infectious diseases and cancers that express an antigen of the antigenic domain.
摘要翻译: 描述了包含抗原结构域和改善的热休克蛋白结合结构域的杂交抗原,其可用于诱导对抗原结构域的免疫应答,因此可用于治疗表达抗原结构域抗原的感染性疾病和癌症。
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