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公开(公告)号：US20050214312A1
公开(公告)日：2005-09-29
申请号：US10820067
申请日：2004-04-08
申请人： Jessica Flechtner , Kenya Prince-Cohane , Sunil Mehta , Paul Slusarewicz , Sofija Andjelic , Brian Barber
发明人： Jessica Flechtner , Kenya Prince-Cohane , Sunil Mehta , Paul Slusarewicz , Sofija Andjelic , Brian Barber
IPC分类号： A61K39/00 , A61K39/385 , C07K14/025 , C07K14/145 , C07K14/47
CPC分类号： C07K14/005 , A61K39/0011 , A61K39/385 , A61K2039/545 , A61K2039/6043 , A61K2039/622 , A61K2039/627 , C07K14/4748 , C07K2319/70 , C12N2710/20022 , C12N2760/20222 , Y02A50/414
摘要： Hybrid antigens comprising at least one antigenic domain, at least one heat shock protein binding domain, and at least one improved peptide linker there between are described which are useful for the induction of an immune response to the antigenic domain when administered alone or in a complex with at least one heat shock protein. The hybrid antigens and complexes can be used to treat infectious diseases and cancers that express an antigen of the antigenic domain.
摘要翻译： 描述了包含至少一个抗原结构域，至少一个热休克蛋白结合结构域和其间至少一个改进的肽接头的杂合抗原，其可用于当单独施用或在复合物中诱导针对抗原结构域的免疫应答时 与至少一个热休克蛋白。 杂交抗原和复合物可用于治疗表达抗原结构域抗原的传染病和癌症。
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公开(公告)号：US20050202033A1
公开(公告)日：2005-09-15
申请号：US10776521
申请日：2004-02-12
申请人： Jessica Flechtner , Kenya Prince-Cohane , Sunil Mehta , Paul Slusarewicz , Sofija Andjelic , Brian Barber
发明人： Jessica Flechtner , Kenya Prince-Cohane , Sunil Mehta , Paul Slusarewicz , Sofija Andjelic , Brian Barber
IPC分类号： A61K20060101 , A61K38/08 , A61K38/17 , A61K39/00 , A61K39/385 , A61K47/48 , A61P35/00 , C07K7/06 , C07K14/47 , C07K14/82 , C07K19/00
CPC分类号： B82Y5/00 , A61K39/0011 , A61K39/385 , A61K47/646 , A61K47/66 , A61K2039/6043 , A61K2039/622 , C07K2319/20 , Y02A50/414
摘要： Hybrid antigens comprising an antigenic domain and improved heat shock protein binding domains are described which are useful for the induction of an immune response to the antigenic domain and thus can be used to treat infectious diseases and cancers that express an antigen of the antigenic domain.
摘要翻译： 描述了包含抗原结构域和改善的热休克蛋白结合结构域的杂交抗原，其可用于诱导对抗原结构域的免疫应答，因此可用于治疗表达抗原结构域抗原的感染性疾病和癌症。
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公开(公告)号：US07309491B2
公开(公告)日：2007-12-18
申请号：US10820067
申请日：2004-04-08
申请人： Paul Slusarewicz , Jessica Baker Flechtner , Sunil Mehta , Kenya Prince-Cohane , Sofija Andjelic , Brian H. Barber
发明人： Paul Slusarewicz , Jessica Baker Flechtner , Sunil Mehta , Kenya Prince-Cohane , Sofija Andjelic , Brian H. Barber
IPC分类号： A61K39/385 , A61K39/00 , A61K39/29
CPC分类号： C07K14/005 , A61K39/0011 , A61K39/385 , A61K2039/545 , A61K2039/6043 , A61K2039/622 , A61K2039/627 , C07K14/4748 , C07K2319/70 , C12N2710/20022 , C12N2760/20222 , Y02A50/414
摘要： Hybrid antigens comprising at least one antigenic domain, at least one heat shock protein binding domain, and at least one improved peptide linker there between are described which are useful for the induction of an immune response to the antigenic domain when administered alone or in a complex with at least one heat shock protein. The hybrid antigens and complexes can be used to treat infectious diseases and cancers that express an antigen of the antigenic domain.
摘要翻译： 描述了包含至少一个抗原结构域，至少一个热休克蛋白结合结构域和其间至少一个改进的肽接头的杂合抗原，其可用于当单独施用或在复合物中诱导针对抗原结构域的免疫应答时 与至少一个热休克蛋白。 杂交抗原和复合物可用于治疗表达抗原结构域抗原的传染病和癌症。
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公开(公告)号：US07420037B2
公开(公告)日：2008-09-02
申请号：US10776521
申请日：2004-02-12
申请人： Paul Slusarewicz , Sunil Mehta
发明人： Paul Slusarewicz , Sunil Mehta
IPC分类号： C07K14/00 , C07K4/00 , A61K39/00 , A61K45/00 , A61K39/385
CPC分类号： B82Y5/00 , A61K39/0011 , A61K39/385 , A61K47/646 , A61K47/66 , A61K2039/6043 , A61K2039/622 , C07K2319/20 , Y02A50/414
摘要： Hybrid antigens comprising an antigenic domain and improved heat shock protein binding domains are described which are useful for the induction of an immune response to the antigenic domain and thus can be used to treat infectious diseases and cancers that express an antigen of the antigenic domain.
摘要翻译： 描述了包含抗原结构域和改进的热休克蛋白结合结构域的杂合抗原，其可用于诱导对抗原结构域的免疫应答，因此可用于治疗表达抗原结构域抗原的感染性疾病和癌症。
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公开(公告)号：US20100040594A1
公开(公告)日：2010-02-18
申请号：US12496045
申请日：2009-07-01
申请人： Paul Slusarewicz , Thomas P. Hedman
发明人： Paul Slusarewicz , Thomas P. Hedman
IPC分类号： A61K38/45 , A61K31/121 , A61K31/352 , A61K31/131 , A61K31/11 , A61K38/16 , A61P19/04
CPC分类号： A61K9/0085 , A61K31/11 , A61K31/121 , A61K31/131 , A61K31/352 , A61K38/45
摘要： Improved methods and compositions for the treatment of native tissues with crosslinkers are provided. The methods and compositions will find particular use in increasing resistance to tearing, fissuring, rupturing, and/or delamination.
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公开(公告)号：US20130085569A1
公开(公告)日：2013-04-04
申请号：US13700091
申请日：2011-05-26
申请人： Thomas P. Hedman , Paul Slusarewicz
发明人： Thomas P. Hedman , Paul Slusarewicz
IPC分类号： A61F2/30
CPC分类号： A61L27/54 , A61F2/0063 , A61F2/30756 , A61F2/3872 , A61F2250/0067 , A61L27/18 , A61L27/34 , A61L27/505 , A61L27/58 , A61L31/043 , A61L31/14 , A61L2300/412 , A61L2430/06
摘要： A method of treating a tear in a knee meniscus of a patient. The method includes exposing the torn knee meniscus to a protein crosslinker during surgery to repair the tear. Also provided is a fixation device for the surgical repair of tears of the meniscus of the knee, where the device contains one or more protein crosslinking reagents.
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公开(公告)号：US08198248B2
公开(公告)日：2012-06-12
申请号：US12203730
申请日：2008-09-03
申请人： Thomas P. Hedman , Paul Slusarewicz
发明人： Thomas P. Hedman , Paul Slusarewicz
IPC分类号： A61K31/352
CPC分类号： A61K31/352 , A61K31/7004
摘要： Improved methods and compositions for the treatment of native tissues with crosslinkers are provided. The methods and compositions will find particular use in increasing resistance to tearing, fissuring, rupturing, and/or delamination.
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公开(公告)号：US20100040593A1
公开(公告)日：2010-02-18
申请号：US12192746
申请日：2008-08-15
申请人： Thomas P. Hedman , Paul Slusarewicz
发明人： Thomas P. Hedman , Paul Slusarewicz
IPC分类号： A61K38/44 , A61K31/121 , A61K31/352 , A61K38/43 , A61K31/13 , A61P19/00 , A61K31/7004
CPC分类号： A61K31/121 , A61K9/0085 , A61K31/13 , A61K31/352 , A61K31/7004 , A61K38/45
摘要： Improved methods and compositions for the treatment of native tissues with crosslinkers are provided. The methods and compositions will find particular use in increasing resistance to tearing, fissuring, rupturing, and/or delamination.
摘要翻译： 提供改进的用交联剂处理天然组织的方法和组合物。 该方法和组合物将特别用于增加抗撕裂，裂缝，破裂和/或分层的抗性。
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公开(公告)号：US06399052B2
公开(公告)日：2002-06-04
申请号：US09878652
申请日：2001-06-11
申请人： Margaret Ann Blount , Michael Arthur Davis , Kelly Jackson , Nathalie Noel , Matthew Leslie Pearce , Paul Slusarewicz
发明人： Margaret Ann Blount , Michael Arthur Davis , Kelly Jackson , Nathalie Noel , Matthew Leslie Pearce , Paul Slusarewicz
IPC分类号： A61K709
摘要： The invention provides the use of a hair benefit agent as an ingredient in a topical hair treatment composition for the purpose of targeting an active endogenous hair fiber enzyme when the composition is applied to the hair, thereby delivering a hair benefit via the interaction of the hair benefit agent with the enzyme.
摘要翻译： 本发明提供了一种头发有益剂作为局部毛发处理组合物中的成分的用途，目的是在将组合物施用于毛发时靶向活性内源性毛发纤维酶，从而通过头发的相互作用递送毛发益处 有益剂与酶。
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公开(公告)号：US08283322B2
公开(公告)日：2012-10-09
申请号：US12496045
申请日：2009-07-01
申请人： Paul Slusarewicz , Thomas P. Hedman
发明人： Paul Slusarewicz , Thomas P. Hedman
CPC分类号： A61K9/0085 , A61K31/11 , A61K31/121 , A61K31/131 , A61K31/352 , A61K38/45
摘要： Improved methods and compositions for the treatment of native tissues with crosslinkers are provided. The methods and compositions will find particular use in increasing resistance to tearing, fissuring, rupturing, and/or delamination.
摘要翻译： 提供改进的用交联剂处理天然组织的方法和组合物。 该方法和组合物将特别用于增加抗撕裂，裂缝，破裂和/或分层的抗性。
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