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公开(公告)号：US07497686B2
公开(公告)日：2009-03-03
申请号：US11171965
申请日：2005-06-30
IPC分类号： A61C5/00
CPC分类号： A61L27/3804 , A61K35/12 , A61L27/3604 , A61L27/3865 , A61L27/3895 , A61L2430/02 , C12N5/0606 , C12N5/0623 , C12N5/0663
摘要： The present invention is based on the discovery that when a tooth primordium is inserted into a mammalian jaw and tooth formation follows, new alveolar bone around the new tooth forms. The present invention is based on the idea of stimulating new tooth formation via the implantation of tooth primordia at selected places in the jaw (e.g. at four points in the molar regions) to result in the formation of bony protuberances which could facilitate denture retention. The teeth may then be removed from the jaw of the patient to leave the new alveolar bone.
摘要翻译： 本发明基于以下发现：当牙根原基插入到哺乳动物颌部并且牙齿形成时，新牙齿周围的新牙槽骨形成。 本发明基于通过在钳口中的选定位置（例如，在摩擦区域中的四个点）植入牙齿原基来刺激新牙齿形成的想法，以导致形成可以促进义齿保留的骨突起物。 然后可以从患者的颌骨上移除牙齿以离开新的牙槽骨。
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公开(公告)号：US07588936B2
公开(公告)日：2009-09-15
申请号：US10546495
申请日：2004-02-17
申请人： Paul Thomas Sharpe
发明人： Paul Thomas Sharpe
CPC分类号： C12N5/0654 , C12N2502/097
摘要： The present invention is based on the discovery that teeth primordia can be generated using bone marrow cells and that bone marrow cells may be employed to generate teeth without the need for purification and expansion of a population of cells.
摘要翻译： 本发明基于以下发现：可以使用骨髓细胞产生牙齿原基，并且可以使用骨髓细胞产生牙齿，而不需要纯化和扩增细胞群体。
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公开(公告)号：US07498168B2
公开(公告)日：2009-03-03
申请号：US10204208
申请日：2001-02-16
申请人： Paul Thomas Sharpe
发明人： Paul Thomas Sharpe
CPC分类号： C12N5/0654 , C12N2501/115 , C12N2501/119 , C12N2501/155 , C12N2501/41 , C12N2502/097 , C12N2502/99 , C12N2506/02
摘要： The invention relates to the use of a cultured stem cell to produce a tooth progenitor cell.
摘要翻译： 本发明涉及培养的干细胞用于产生牙祖细胞的用途。
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