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    Peptide Sequences and Compositions
    3.
    发明申请
    Peptide Sequences and Compositions 有权
    肽序列和组合物

    公开(公告)号：US20150182618A1

    公开(公告)日：2015-07-02

    申请号：US14656690

    申请日：2015-03-12

    申请人： PepTcell, Ltd.

    发明人： Gregory Alan Stoloff ,  Wilson Romero Caparros-Wanderlay

    IPC分类号： A61K39/21 ,  C12N7/00 ,  C07K14/005

    CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/55544 ,  C07K14/005 ,  C07K2319/01 ,  C12N7/00 ,  C12N2740/16034 ,  C12N2740/16071 ,  C12N2740/16322 ,  C12N2740/16334

    摘要： Provided is a polypeptide having no more than 100 amino acids, which polypeptide comprises one or more sequences having at least 60% homology with any of SEQ ID 1-4, or comprises two or more epitopes having 7 amino acids or more, each epitope having at least 60% homology with a sub-sequence of any of SEQ ID 1-4 that has the same length as the epitope: SEQ ID 1 GDTWAGVEAIIRILQQLLFIHFRIGCQHSR SEQ ID 2 KVGSLQYLALTALITPKKIKPPLPSVKKLTEDRWNKPQKT SEQ ID 3 EPVPLQLPPLERLTLDCSEDCGTSGTQ SEQ ID 4 YKGALDLSHFLKEKGGLEGLIYSQKRQDILDLWVYHTQGYFPD wherein, the polypeptide is immunogenic in a vertebrate expressing a major histocompatibility complex (MHC) allele, and wherein the polypeptide is not a complete HIV virus protein.

    摘要翻译： 提供的多肽具有不超过100个氨基酸，该多肽包含与SEQ ID 1-4中任一个具有至少60％同源性的一个或多个序列，或包含两个或多个具有7个氨基酸或更多个的表位，每个表位具有 与具有与表位相同长度的任何SEQ ID 1-4的亚序列具有至少60％的同源性：SEQ ID NO：1。GDTWAGVEAIIRILQQLLFIHFRIGCQHSR SEQ ID 2 KVGSLQYLALTALITPKKIKPPLPSVKKLTEDRWNKPQKT SEQ ID 3 EPVPLQLPPLERLTLDCSEDCGTSGTQ SEQ ID 4 YKGALDLSHFLKEKGGLEGLIYSQKRQDILDLWVYHTQGYFPD其中，该多肽是免疫原性的 表达主要组织相容性复合体（MHC）等位基因的脊椎动物，并且其中所述多肽不是完整的HIV病毒蛋白。

    Peptide sequences and compositions
    4.
    再颁专利
    Peptide sequences and compositions 有权

    公开(公告)号：USRE47222E1

    公开(公告)日：2019-02-05

    申请号：US15469016

    申请日：2017-03-24

    申请人： PepTcell, Ltd.

    发明人： Gregory Alan Stoloff ,  Wilson Romero Caparros-Wanderley

    IPC分类号： A61K39/002 ,  C07K14/445 ,  C07K14/435 ,  A61K39/005 ,  A61K39/00 ,  A61K38/00

    摘要： Provided is a polypeptide composition comprising one or more polypeptides, which polypeptides are immunogenic in a vertebrate such that they cause the vertebrate to produce immune system cells capable of recognizing at least one epitope from an arthropod saliva protein fraction, wherein the arthropod saliva protein fraction has a mass of 40 kDA or less, and wherein the polypeptides are selected independently from: the polypeptide sequences of SEQ ID 1-44 or sub-sequences from these sequences, the sub-sequences having 7 amino acids or more; or from polypeptide sequences having 85% homology or more with one or more of the above sequences and contained in one or more of the following databases: GenBank, Protein Data Bank (PDB), SwissProt, Protein Information Resource (PIR), Protein Research Foundation (PRF), or CDS translations of these.