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公开(公告)号：US20210327107A1
公开(公告)日：2021-10-21
申请号：US16339445
申请日：2018-03-30
发明人： Ali Behrooz
摘要： Presented herein are systems and methods for tomographic imaging of a region of interest in a subject using short-wave infrared light to provide for accurate reconstruction of absorption maps within the region of interest. The reconstructed absorption maps are representations of the spatial variation in tissue absorption within the region of interest. The reconstructed absorption maps can themselves be used to analyze anatomical properties and biological processes within the region of interest, and/or be used as input information about anatomical properties in order to facilitate data processing used to obtain images of the region of interest via other imaging modalities. For example, the reconstructed absorption maps may be incorporated into forward models that are used in tomographic reconstruction processing in fluorescence and other contrast-based tomographic imaging modalities. Incorporating reconstructed absorption maps into other tomographic reconstruction processing algorithms in this manner improves the accuracy of the resultant reconstructions.
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2.发明申请公开(公告)号：US20180360404A1
公开(公告)日：2018-12-20
申请号：US15985070
申请日：2018-05-21
发明人： Ali Behrooz , Peet Kask
IPC分类号： A61B6/00 , G06K9/52 , G06T7/62 , G06T7/11 , G06T15/08 , G06T15/00 , G06T7/187 , G06K9/46 , A61B6/03
CPC分类号： A61B6/505 , A61B6/032 , A61B6/508 , G06K9/4604 , G06K9/52 , G06K2009/4666 , G06T7/11 , G06T7/187 , G06T7/62 , G06T15/00 , G06T15/08 , G06T2200/04 , G06T2207/30008
摘要： Presented herein, in certain embodiments, are approaches for robust bone splitting and segmentation in the context of small animal imaging, for example, microCT imaging. In certain embodiments, a method for calculating and applying single and hybrid second-derivative splitting filters to gray-scale images and binary bone masks is described. These filters can accurately identify the split lines/planes of the bones even for low-resolution data, and hence accurately morphologically disconnect the individual bones. The split bones can then be used as seeds in region growing techniques such as marker-controlled watershed segmentation. With this approach, the bones can be segmented with much higher robustness and accuracy compared to prior art methods.
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公开(公告)号：US11989803B2
公开(公告)日：2024-05-21
申请号：US16339445
申请日：2018-03-30
发明人： Ali Behrooz
CPC分类号： G06T11/006 , A61B5/0073 , A61B5/704 , G06T11/005 , A61B2503/40
摘要： Presented herein are systems and methods for tomographic imaging of a region of interest in a subject using short-wave infrared light to provide for accurate reconstruction of absorption maps within the region of interest. The reconstructed absorption maps are representations of the spatial variation in tissue absorption within the region of interest. The reconstructed absorption maps can themselves be used to analyze anatomical properties and biological processes within the region of interest, and/or be used as input information about anatomical properties in order to facilitate data processing used to obtain images of the region of interest via other imaging modalities. For example, the reconstructed absorption maps may be incorporated into forward models that are used in tomographic reconstruction processing in fluorescence and other contrast-based tomographic imaging modalities. Incorporating reconstructed absorption maps into other tomographic reconstruction processing algorithms in this manner improves the accuracy of the resultant reconstructions.
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4.发明授权公开(公告)号：US11219424B2
公开(公告)日：2022-01-11
申请号：US16724722
申请日：2019-12-23
发明人： Ali Behrooz , Joshua Kempner
摘要： Presented herein are efficient and reliable systems and methods for calculating and extracting three-dimensional central axes of bones of animal subjects—for example, animal subjects scanned by in vivo or ex vivo microCT platforms—to capture both the general and localized tangential directions of the bone, along with its shape, form, curvature, and orientation. With bone detection and segmentation algorithms, the skeletal bones of animal subjects scanned by CT or microCT scanners can be detected, segmented, and visualized. Three dimensional central axes determined using these methods provide important information about the skeletal bones.
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5.发明申请公开(公告)号：US20200178919A1
公开(公告)日：2020-06-11
申请号：US16724722
申请日：2019-12-23
发明人： Ali Behrooz , Joshua Kempner
摘要： Presented herein are efficient and reliable systems and methods for calculating and extracting three-dimensional central axes of bones of animal subjects—for example, animal subjects scanned by in vivo or ex vivo microCT platforms—to capture both the general and localized tangential directions of the bone, along with its shape, form, curvature, and orientation. With bone detection and segmentation algorithms, the skeletal bones of animal subjects scanned by CT or microCT scanners can be detected, segmented, and visualized. Three dimensional central axes determined using these methods provide important information about the skeletal bones.
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6.发明授权公开(公告)号：US10548553B2
公开(公告)日：2020-02-04
申请号：US16155943
申请日：2018-10-10
发明人： Ali Behrooz , Joshua Kempner
摘要： Presented herein are efficient and reliable systems and methods for calculating and extracting three-dimensional central axes of bones of animal subjects—for example, animal subjects scanned by in vivo or ex vivo microCT platforms—to capture both the general and localized tangential directions of the bone, along with its shape, form, curvature, and orientation. With bone detection and segmentation algorithms, the skeletal bones of animal subjects scanned by CT or microCT scanners can be detected, segmented, and visualized. Three dimensional central axes determined using these methods provide important information about the skeletal bones.
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7.发明授权公开(公告)号：US11302008B2
公开(公告)日：2022-04-12
申请号：US16339923
申请日：2018-03-30
发明人： Ali Behrooz
摘要： Presented herein are systems and methods that allow for vertebral centrums of individual vertebrae to be identified and segmented within a 3D image of a subject (e.g., a CT or microCT image). In certain embodiments, the approaches described herein identify, within a graphical representation of an individual vertebra in a 3D image of a subject, multiple discrete and differentiable regions, one of which corresponds to a vertebral centrum of the individual vertebra. The region corresponding to the vertebral centrum may be automatically or manually (e.g., via a user interaction) classified as such. Identifying vertebral centrums in this manner facilitates streamlined quantitative analysis of 3D images for osteological research, notably, providing a basis for rapid and consistent evaluation of vertebral centrum morphometric attributes.
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公开(公告)号：US20190124247A1
公开(公告)日：2019-04-25
申请号：US16163094
申请日：2018-10-17
发明人： Ali Behrooz , William Hurley , Ilias Faqir
IPC分类号： H04N5/235
摘要： Presented herein are systems and methods that provide for fast image acquisition with a CCD camera for tomographic imaging by synchronizing illumination with the image acquisition sequence of the CCD camera. The systems and methods described herein allow images to be acquired with a CCD camera using short image acquisition times that would otherwise result in the introduction of severe artifacts into the acquired images. This unique capability is achieved by selectively illuminating the one or more object(s) to be imaged during specific phases of the CCD camera that are used to acquire an image. Reducing the time required to acquire artifact-free images in this manner allows for rapid imaging with a CCD camera. This capability is of particular relevance to tomographic imaging approaches, in which multiple images of one or more objects are acquired and used to produce a single tomographic image.
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9.发明申请公开(公告)号：US20190046144A1
公开(公告)日：2019-02-14
申请号：US16155943
申请日：2018-10-10
发明人： Ali Behrooz , Joshua Kempner
CPC分类号： A61B6/505 , A61B6/032 , A61B6/5217 , G06T7/0012 , G06T7/62 , G06T2207/10081 , G06T2207/20036 , G06T2207/20044 , G06T2207/30008 , G06T2207/30024 , G06T2207/30172
摘要： Presented herein are efficient and reliable systems and methods for calculating and extracting three-dimensional central axes of bones of animal subjects—for example, animal subjects scanned by in vivo or ex vivo microCT platforms—to capture both the general and localized tangential directions of the bone, along with its shape, form, curvature, and orientation. With bone detection and segmentation algorithms, the skeletal bones of animal subjects scanned by CT or microCT scanners can be detected, segmented, and visualized. Three dimensional central axes determined using these methods provide important information about the skeletal bones.
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10.发明授权公开(公告)号：US09999400B2
公开(公告)日：2018-06-19
申请号：US14812483
申请日：2015-07-29
发明人： Ali Behrooz , Peet Kask
IPC分类号： G06K9/00 , A61B6/00 , G06K9/52 , G06K9/46 , G06T15/08 , G06T15/00 , G06T7/11 , G06T7/187 , G06T7/62 , A61B6/03
CPC分类号： A61B6/505 , A61B6/032 , A61B6/508 , G06K9/4604 , G06K9/52 , G06K2009/4666 , G06T7/11 , G06T7/187 , G06T7/62 , G06T15/00 , G06T15/08 , G06T2200/04 , G06T2207/30008
摘要： Presented herein, in certain embodiments, are approaches for robust bone splitting and segmentation in the context of small animal imaging, for example, microCT imaging. In certain embodiments, a method for calculating and applying single and hybrid second-derivative splitting filters to gray-scale images and binary bone masks is described. These filters can accurately identify the split lines/planes of the bones even for low-resolution data, and hence accurately morphologically disconnect the individual bones. The split bones can then be used as seeds in region growing techniques such as marker-controlled watershed segmentation. With this approach, the bones can be segmented with much higher robustness and accuracy compared to prior art methods.
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