公开(公告)号：US10087207B2

公开(公告)日：2018-10-02

申请号：US15361083

申请日：2016-11-25

申请人： Personal Genomics, Inc.

发明人： Tsu-Ju Fu ,  Shang-Chia Chang ,  Jenn-Yeh Fann

IPC分类号： C07H19/10 ,  C12Q1/6876 ,  C12Q1/6869

摘要： This invention is to describe nucleotide analogs used in a method for the determination of a nucleic acid sequence. The method involves an enzyme, an enzyme complex or plural number of enzymes with more than one enzymatic activity and a set of nucleotide analogs, to achieve high signal readout accuracy in nucleic acid sequencing by making each signal to have a long signaling time span which allows a higher signal clarity.

公开(公告)号：US20170073752A1

公开(公告)日：2017-03-16

申请号：US15361083

申请日：2016-11-25

申请人： Personal Genomics, Inc.

发明人： Tsu-Ju Fu ,  Shang-Chia Chang ,  Jenn-Yeh Fann

IPC分类号： C12Q1/68

CPC分类号： C07H19/10 ,  C12Q1/6869 ,  C12Q1/6876 ,  C12Q2525/113 ,  C12Q2563/107

摘要： This invention is to describe nucleotide analogs used in a method for the determination of a nucleic acid sequence. The method involves an enzyme, an enzyme complex or plural number of enzymes with more than one enzymatic activity and a set of nucleotide analogs, to achieve high signal readout accuracy in nucleic acid sequencing by making each signal to have a long signaling time span which allows a higher signal clarity.

摘要翻译： 本发明是描述用于确定核酸序列的方法中使用的核苷酸类似物。 该方法包括酶，酶复合物或具有多于一种酶活性的多种酶和一组核苷酸类似物，以通过使每个信号具有长的信号时间跨度来实现核酸测序中的高信号读出准确度，这允许 更高的信号清晰度。

公开(公告)号：US09540688B2

公开(公告)日：2017-01-10

申请号：US14566715

申请日：2014-12-11

申请人： Personal Genomics, Inc.

发明人： Tsu-Ju Fu ,  Shang-Chia Chang ,  Jenn-Yeh Fann

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： C07H19/10 ,  C12Q1/6869 ,  C12Q1/6876 ,  C12Q2525/113 ,  C12Q2563/107

摘要： This invention is to describe a method for the determination of a nucleic acid sequence, in which it involves an enzyme, an enzyme complex or plural number of enzymes with more than one enzymatic activity and a set of nucleotide analogs, to achieve high signal readout accuracy in nucleic acid sequencing by making each signal to have a long signaling time span which allows a higher signal clarity.

摘要翻译： 本发明描述了一种用于确定核酸序列的方法，其中它涉及酶，酶复合物或具有多于一种酶活性的多种酶和一组核苷酸类似物，以实现高信号读出精度 在核酸测序中，通过使每个信号具有长的信令时间跨度，这允许更高的信号清晰度。

公开(公告)号：US20150232928A1

公开(公告)日：2015-08-20

申请号：US14566715

申请日：2014-12-11

申请人： Personal Genomics, Inc.

发明人： Tsu-Ju Fu ,  Shang-Chia Chang ,  Jenn-Yeh Fann

IPC分类号： C12Q1/68

CPC分类号： C07H19/10 ,  C12Q1/6869 ,  C12Q1/6876 ,  C12Q2525/113 ,  C12Q2563/107

摘要： This invention is to describe a method for the determination of a nucleic acid sequence, in which it involves an enzyme, an enzyme complex or plural number of enzymes with more than one enzymatic activity and a set of nucleotide analogs, to achieve high signal readout accuracy in nucleic acid sequencing by making each signal to have a long signaling time span which allows a higher signal clarity.

摘要翻译： 本发明描述了一种用于确定核酸序列的方法，其中它涉及酶，酶复合物或具有多于一种酶活性的多种酶和一组核苷酸类似物，以实现高信号读出精度 在核酸测序中，通过使每个信号具有长的信令时间跨度，这允许更高的信号清晰度。

公开(公告)号：US20150232915A1

公开(公告)日：2015-08-20

申请号：US14183533

申请日：2014-02-19

申请人： Personal Genomics, Inc.

发明人： Tsu-Ju Fu ,  Shang-Chia Chang ,  Jenn-Yeh Fann

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6806 ,  C12Q1/6869 ,  C12Q2523/319 ,  C12Q2525/117 ,  C12Q2535/107

摘要： This invention is to describe a method for the determination of a nucleic acid sequence, in which it involves an enzyme, an enzyme complex or plural number of enzymes with more than one enzymatic activity and a set of nucleotide analogs, to achieve high signal readout accuracy in nucleic acid sequencing by making each signal to have a long signaling time span which allows a higher signal clarity.

摘要翻译： 本发明描述了一种用于确定核酸序列的方法，其中它涉及酶，酶复合物或具有多于一种酶活性的多种酶和一组核苷酸类似物，以实现高信号读出精度 在核酸测序中，通过使每个信号具有长的信令时间跨度，这允许更高的信号清晰度。