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公开(公告)号：US07776574B2
公开(公告)日：2010-08-17
申请号：US10849229
申请日：2004-05-20
申请人： Perurmadom Ramaiyer Mahadevan , Sita Mahadevan, legal representative , Subrahmanyam Chivukula Sekar , Sundaramurthy Suresh Babu
CPC分类号： C12N9/6432 , C12Y304/21006 , Y10S435/814 , Y10S435/822 , Y10S435/832
摘要： The invention relates to a thrombolytic enzyme referred to as Thrombinase having a molecular weight of 31,000 to 32,000. Such a thrombolytic enzyme can be used for dissolving blood clots. The process comprises culturing a filtrate of Bacillus sphaericus sero type H5a 5b, removing the cell, subjecting the cell supernatant to filtration, salting out the retentate, subjecting the precipitate to dialysis, reprecipitating the precipitate and then reconstituting in buffer and finally decolourizing, purifying and dialyzing.
摘要翻译： 本发明涉及一种称为分子量为31,000至32,000的凝血酶的溶栓酶。 这种血栓溶解酶可用于溶血栓。 该方法包括培养球形芽孢杆菌血清型H5a 5b的滤液，除去细胞，使细胞上清液过滤，盐析出滞留物，沉淀物透析，再沉淀沉淀物，然后在缓冲液中重新配制，最后脱色，纯化和 透析
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公开(公告)号：US20090285793A1
公开(公告)日：2009-11-19
申请号：US11907512
申请日：2007-10-12
申请人： Perurmadom Ramaiyer Mahadevan , Sita Mahadevan , Subrahamanyam Chivukula Sekar , Sundaramurthy Suresh Babu
发明人： Perurmadom Ramaiyer Mahadevan , Sita Mahadevan , Subrahamanyam Chivukula Sekar , Sundaramurthy Suresh Babu
CPC分类号： C12N9/6432 , C12Y304/21006 , Y10S435/814 , Y10S435/822 , Y10S435/832
摘要： The invention relates to a thrombolytic enzyme referred to as Thrombinase having a molecular weight of 31,000 to 32,000. Such a thrombolytic enzyme can be used for dissolving blood clots. The process comprises culturing a filtrate of Bacillus sphaericus sero type H5a 5b, removing the cell, subjecting the cell supernatant to filtration, salting out the retentate, subjecting the precipitate to dialysis, reprecipitating the precipitate and then reconstituting in buffer and finally decolourizing, purifying and dialyzing.
摘要翻译： 本发明涉及一种称为分子量为31,000至32,000的凝血酶的溶栓酶。 这种血栓溶解酶可用于溶血栓。 该方法包括培养球形芽孢杆菌血清型H5a 5b的滤液，除去细胞，使细胞上清液过滤，盐析出滞留物，沉淀物透析，再沉淀沉淀物，然后在缓冲液中重新配制，最后脱色，纯化和 透析
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公开(公告)号：US08835145B2
公开(公告)日：2014-09-16
申请号：US11907512
申请日：2007-10-12
CPC分类号： C12N9/6432 , C12Y304/21006 , Y10S435/814 , Y10S435/822 , Y10S435/832
摘要： The invention relates to a thrombolytic enzyme referred to as Thrombinase having a molecular weight of 31,000 to 32,000. Such a thrombolytic enzyme can be used for dissolving blood clots. The process comprises culturing a filtrate of Bacillus sphaericus sero type H5a 5b, removing the cell, subjecting the cell supernatant to filtration, salting out the retentate, subjecting the precipitate to dialysis, reprecipitating the precipitate and then reconstituting in buffer and finally decolorizing, purifying and dialyzing.
摘要翻译： 本发明涉及一种称为分子量为31,000至32,000的凝血酶的溶栓酶。 这种血栓溶解酶可用于溶血栓。 该方法包括培养芽孢杆菌血清型H5a 5b的滤液，去除细胞，对细胞上清液进行过滤，盐析，渗析，沉淀物透析，再沉淀沉淀，然后重新沉淀，最后脱色，纯化和 透析
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