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公开(公告)号：US20050234056A1
公开(公告)日：2005-10-20
申请号：US11130429
申请日：2005-05-16
申请人： Peter Aranyi , Laszlo Balazs , Maria Balogh , Sandor Batori , Lajos Nagy , Geza Timari , Kinga Boer , Zoltan Kapui , Endre Mikus , Katalin Gerber , Judit Vargane Szeredi , Katalin Szabo , Erzsebet Walcz
发明人： Peter Aranyi , Laszlo Balazs , Maria Balogh , Sandor Batori , Lajos Nagy , Geza Timari , Kinga Boer , Zoltan Kapui , Endre Mikus , Katalin Gerber , Judit Vargane Szeredi , Katalin Szabo , Erzsebet Walcz
IPC分类号： A61K31/415 , A61P3/00 , A61P9/00 , A61P11/00 , A61P13/12 , A61P17/00 , A61P25/00 , A61P29/00 , A61P35/00 , C07D471/04 , A61K31/5377 , A61K31/496
CPC分类号： C07D471/04 , A61K31/415
摘要： This invention is directed to a compound of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, Z, m, n, o, p and r are as defined herein, its preparation, pharmaceutical composition and use as an adenosine A3 receptor ligand preferably an antagonist.
摘要翻译： 本发明涉及式（I）化合物，其中R 1，R 2，R 3，R 4， R 5，R 6，R 7，R 8，R 9，R 9， R 10，X，Z，m，n，o，p和r如本文所定义，其制备，药物组合物和用作腺苷A 3 >受体配体优选为拮抗剂。
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公开(公告)号：US07419977B2
公开(公告)日：2008-09-02
申请号：US11130429
申请日：2005-05-16
申请人： Peter Aranyi , Laszlo Balazs , Maria Balogh , Sandor Batori , Lajos T. Nagy , Geza Timari , Kinga Boer , Zoltan Kapui , Endre Mikus , Katalin Gerber , Judit Vargane Szeredi , Katalin Urban Szabo , Erzsebet Walcz
发明人： Peter Aranyi , Laszlo Balazs , Maria Balogh , Sandor Batori , Lajos T. Nagy , Geza Timari , Kinga Boer , Zoltan Kapui , Endre Mikus , Katalin Gerber , Judit Vargane Szeredi , Katalin Urban Szabo , Erzsebet Walcz
IPC分类号： A61K31/5377 , C07D411/14
CPC分类号： C07D471/04 , A61K31/415
摘要： This invention is directed to a compound of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, Z, m, n, o, p and r are as defined herein, its preparation, pharmaceutical composition and use as an adenosine A3 receptor ligand preferably an antagonist.
摘要翻译： 本发明涉及式（I）化合物，其中R 1，R 2，R 3，R 4， R 5，R 6，R 7，R 8，R 9，R 9， R 10，X，Z，m，n，o，p和r如本文所定义，其制备，药物组合物和用作腺苷A 3 >受体配体优选为拮抗剂。
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公开(公告)号：US07709489B2
公开(公告)日：2010-05-04
申请号：US12140512
申请日：2008-06-17
申请人： Peter Aranyi , Laszlo Balazs , Maria Balogh , Sandor Batori , Lajos T. Nagy , Geza Timari , Kinga Boer , Zoltan Kapui , Endre Mikus , Katalin Gerber , Judit Vargane Szeredi , Katalin Urban-Szabo , Erzsebet Walcz
发明人： Peter Aranyi , Laszlo Balazs , Maria Balogh , Sandor Batori , Lajos T. Nagy , Geza Timari , Kinga Boer , Zoltan Kapui , Endre Mikus , Katalin Gerber , Judit Vargane Szeredi , Katalin Urban-Szabo , Erzsebet Walcz
IPC分类号： A61K31/496 , C07D403/14 , C07D403/06
CPC分类号： C07D471/04 , A61K31/415
摘要： This invention is directed to a compound of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, Z, m, n, o, p and r are as defined herein, its preparation, pharmaceutical composition and use as an adenosine A3 receptor ligand preferably an antagonist.
摘要翻译： 本发明涉及式（I）化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10，X，Z，m，n，o，p和r如 本文中，其制备，药物组合物和用作腺苷A3受体配体优选为拮抗剂。
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公开(公告)号：US20050070566A1
公开(公告)日：2005-03-31
申请号：US10499251
申请日：2002-12-17
申请人： Peter Aranyl , Laszlo Balazs , Maria Balogh , Sandor Batori , Kinga Boer , Katalin Gerber , Zoltan Kapui , Endre Mikus , Geza Timari , T. Lajos , Katalin Urban-Szabo , Judit Vargane Szeredi
发明人： Peter Aranyl , Laszlo Balazs , Maria Balogh , Sandor Batori , Kinga Boer , Katalin Gerber , Zoltan Kapui , Endre Mikus , Geza Timari , T. Lajos , Katalin Urban-Szabo , Judit Vargane Szeredi
IPC分类号： C07D215/54 , A61K31/437 , A61K31/4545 , A61K31/4706 , A61K31/4709 , A61P1/04 , A61P3/04 , A61P3/10 , A61P7/00 , A61P9/00 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/04 , A61P17/06 , A61P19/02 , A61P25/00 , A61P25/16 , A61P25/24 , A61P25/28 , A61P27/02 , A61P27/06 , A61P27/16 , A61P29/00 , A61P35/00 , A61P37/02 , A61P37/08 , A61P43/00 , C07D215/56 , C07D405/12 , C07D409/12 , C07D471/04 , C07D487/04 , A61K31/4745 , C07D455/04
CPC分类号： C07D471/04
摘要： The present invention relates to adenosine A3 receptor ligands of the general formula (I), within those preferably antagonists, as well as their salts, solvates and isomers, and the pharmaceutical compositions containings them, to the use of the compounds of the general formula (I), as well as their salts, solvates and isomers, to the preparation of the compounds of the general formula (I) and (heir salts, solvates and isomers, furthermore to the new intermediates of the general formulae (II) and (III) and to the preparation thereof.
摘要翻译： 本发明涉及通式（I）的腺苷A3受体配体，其中优选的是拮抗剂，以及它们的盐，溶剂化物和异构体，并且药物组合物包含它们，以使用通式（ I）以及它们的盐，溶剂合物和异构体制备通式（I）的化合物和（继续人的盐，溶剂合物和异构体，以及通式（II）和（III）的新中间体 ）及其制备。
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公开(公告)号：US20050124648A1
公开(公告)日：2005-06-09
申请号：US10499250
申请日：2002-12-17
申请人： Peter Aranyi , Laszlo Balazs , Sandor Batori , Judit Bence , Kinga Boer , Felix Hadju , Zoltan Kapui , Endre Mikus , Tibor Szabo , Lajos T. Nagy , Geza Timari , Katalin Urban-Szabo , Erzsebet Walcz
发明人： Peter Aranyi , Laszlo Balazs , Sandor Batori , Judit Bence , Kinga Boer , Felix Hadju , Zoltan Kapui , Endre Mikus , Tibor Szabo , Lajos T. Nagy , Geza Timari , Katalin Urban-Szabo , Erzsebet Walcz
IPC分类号： A61K31/437 , A61K31/444 , A61P9/00 , A61P11/00 , A61P13/12 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/02 , A61P37/06 , C07B61/00 , C07D215/54 , C07D215/56 , C07D471/04 , A61K31/4745
CPC分类号： C07D471/04 , C07D215/54 , C07D215/56
摘要： The present invention relates to adenosine A-3? receptor ligands of the general formula (I), within those preferably antagonists, as well as their salts, solvates and isomers, and the pharmaceutical compositions containing them, to the use of the compounds of the general formula (I), as well as their salts, solvates and isomers, to the preparation of the compounds of the general formula (I) and theirs salts, solvates and isomers, furthermore to the new intermediates of the general formulae (II) and to the preparation thereof.
摘要翻译： 本发明涉及腺苷A-
3？ 通式（I）的受体配体，在这些优选的拮抗剂中，以及它们的盐，溶剂合物和异构体，以及含有它们的药物组合物，通式（I）的化合物以及它们的 盐，溶剂合物和异构体，制备通式（I）化合物及其盐，溶剂合物和异构体，以及通式（II）的新中间体及其制备方法。
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公开(公告)号：US07713992B2
公开(公告)日：2010-05-11
申请号：US12039272
申请日：2008-02-28
申请人： Peter Aranyi , Laszlo Balazs , Sandor Batori , Judit Bence , Kinga Boer , Felix Hajdu , Zoltan Kapui , Endre Mikus , Tibor Szabo , Lajos T. Nagy , Geza Timari , Katalin Urban-Szabo , Erzsebet Walcz
发明人： Peter Aranyi , Laszlo Balazs , Sandor Batori , Judit Bence , Kinga Boer , Felix Hajdu , Zoltan Kapui , Endre Mikus , Tibor Szabo , Lajos T. Nagy , Geza Timari , Katalin Urban-Szabo , Erzsebet Walcz
IPC分类号： A61K31/4355 , A61K31/4196
CPC分类号： C07D471/04 , C07D215/54 , C07D215/56
摘要： The present invention relates to adenosine A3 receptor ligands of the general formula (I), within those preferably antagonists, as well as their salts, solvates and isomers, and the pharmaceutical compositions containing them, to the use of the compounds of the general formula (I), as well as their salts, solvates and isomers, to the preparation of the compounds of the general formula (I) and their salts, solvates and isomers, furthermore to the new intermediates of the general formulae (II) and to the preparation thereof.
摘要翻译： 本发明涉及通式（I）的腺苷A3受体配体，其中优选为拮抗剂，以及它们的盐，溶剂化物和异构体，以及含有它们的药物组合物，以及通式 I）以及它们的盐，溶剂合物和异构体，通式（I）的化合物及其盐，溶剂合物和异构体的制备，以及通式（II）的新中间体和制备 其中。
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公开(公告)号：US07365089B2
公开(公告)日：2008-04-29
申请号：US10499250
申请日：2002-12-17
申请人： Peter Aranyi , Laszlo Balazs , Sandor Batori , Judit Bence , Kinga Boer , Felix Hajdu , Zoltan Kapui , Endre Mikus , Tibor Szabo , Lajos T. Nagy , Geza Timari , Katalin Urban-Szabo , Erzsebet Walcz
发明人： Peter Aranyi , Laszlo Balazs , Sandor Batori , Judit Bence , Kinga Boer , Felix Hajdu , Zoltan Kapui , Endre Mikus , Tibor Szabo , Lajos T. Nagy , Geza Timari , Katalin Urban-Szabo , Erzsebet Walcz
IPC分类号： A61K31/4196 , A61K31/4406 , C07D251/72
CPC分类号： C07D471/04 , C07D215/54 , C07D215/56
摘要： The present invention relates to adenosine A3? receptor ligands of the general formula (I), within those preferably antagonists, as well as their salts, solvates and isomers, and the pharmaceutical compositions containing them, to the use of the compounds of the general formula (I), as well as their salts, solvates and isomers, to the preparation of the compounds of the general formula (I) and theirs salts, solvates and isomers, furthermore to the new intermediates of the general formulae (II) and to the preparation thereof.
摘要翻译： 本发明涉及腺苷A
3？ 通式（I）的受体配体，在这些优选的拮抗剂中，以及它们的盐，溶剂合物和异构体，以及含有它们的药物组合物，通式（I）的化合物以及它们的 盐，溶剂合物和异构体，制备通式（I）化合物及其盐，溶剂合物和异构体，以及通式（II）的新中间体及其制备方法。
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公开(公告)号：US20080146604A1
公开(公告)日：2008-06-19
申请号：US12039272
申请日：2008-02-28
申请人： Peter Aranyi , Laszlo Balazs , Sandor Batori , Judit Bence , Kinga Boer , Felix Hajdu , Zoltan Kapui , Endre Mikus , Tibor Szabo , Lajos T. Nagy , Geza Timari , Katalin Urban-Szabo , Erzsebet Walcz
发明人： Peter Aranyi , Laszlo Balazs , Sandor Batori , Judit Bence , Kinga Boer , Felix Hajdu , Zoltan Kapui , Endre Mikus , Tibor Szabo , Lajos T. Nagy , Geza Timari , Katalin Urban-Szabo , Erzsebet Walcz
CPC分类号： C07D471/04 , C07D215/54 , C07D215/56
摘要： The present invention relates to adenosine A3 receptor ligands of the general formula (I), within those preferably antagonists, as well as their salts, solvates and isomers, and the pharmaceutical compositions containing them, to the use of the compounds of the general formula (I), as well as their salts, solvates and isomers, to the preparation of the compounds of the general formula (I) and their salts, solvates and isomers, furthermore to the new intermediates of the general formulae (II) and to the preparation thereof.
摘要翻译： 本发明涉及通式（I）的腺苷A 3 N 3受体配体，其中优选的是拮抗剂，以及它们的盐，溶剂化物和异构体，以及含有它们的药物组合物 的通式（I）化合物及其盐，溶剂合物和异构体制备通式（I）化合物及其盐，溶剂合物和异构体，此外还涉及一般的新的中间体 式（II）及其制备方法。
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公开(公告)号：US20050130981A1
公开(公告)日：2005-06-16
申请号：US10507005
申请日：2003-03-04
申请人： Peter Aranyl , Laszlo Balazs , Imre Bata , Sandor Batori , Eva Boronkay , Philippe Bovy , Karoly Kanai , Zoltan Kapui , Edit Susan , Tibor Szabo , Lajos Nagy , Katalin Urban-Szabo , Marton Varga
发明人： Peter Aranyl , Laszlo Balazs , Imre Bata , Sandor Batori , Eva Boronkay , Philippe Bovy , Karoly Kanai , Zoltan Kapui , Edit Susan , Tibor Szabo , Lajos Nagy , Katalin Urban-Szabo , Marton Varga
IPC分类号： A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/46 , A61K31/497 , A61K31/501 , A61P1/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/12 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/04 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P29/00 , A61P31/18 , A61P35/00 , A61P37/00 , A61P37/08 , A61P43/00 , C07D207/16 , C07D211/58 , C07D401/04 , C07D401/14 , C07D405/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D451/04 , C07D451/14 , C07D43/14 , A61K31/506
CPC分类号： C07D451/04 , C07D207/16 , C07D211/58 , C07D401/04 , C07D401/14 , C07D405/06 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D451/14
摘要： The present invention relates to new, potent DPP-IV enzyme inhibitors of the general formula (I), which contain fluorine atoms.
摘要翻译： 本发明涉及含有氟原子的新的具有通式（I）的DPP-IV酶抑制剂。
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公开(公告)号：US20050153973A1
公开(公告)日：2005-07-14
申请号：US10518114
申请日：2003-06-11
申请人： Peter Aranyl , Laszlo Balazs , Imre Bata , Sandor Batori , Eva Boronkay , Zoltan Kapui , Edit Susan , Tibor Szabo , Lajos Nagy , Katalin Urban-Szabo , Marton Varga
发明人： Peter Aranyl , Laszlo Balazs , Imre Bata , Sandor Batori , Eva Boronkay , Zoltan Kapui , Edit Susan , Tibor Szabo , Lajos Nagy , Katalin Urban-Szabo , Marton Varga
IPC分类号： A61K31/439 , A61K31/444 , A61K31/496 , A61K31/506 , A61P3/00 , A61P3/10 , A61P13/12 , A61P17/00 , A61P25/18 , A61P25/22 , A61P29/00 , A61P31/18 , A61P35/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D207/06 , C07D207/16 , C07D263/06 , C07D277/06 , C07D451/04 , C07D451/14 , C07D417/14 , A61K31/4439 , A61K31/497 , A61K31/501
CPC分类号： C07D451/04 , C07D207/06 , C07D207/16 , C07D263/06 , C07D277/06 , C07D451/14
摘要： Heterocyclic amides useful as inhibitors of dipeptylpeptidase-IV (DPP-IV) enzyme, process for the preparation thereof and intermediates therefore.
摘要翻译： 可用作二肽肽酶-IV（DPP-IV）酶抑制剂的杂环酰胺，因此其制备方法和中间体。
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