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公开(公告)号：US08871212B2
公开(公告)日：2014-10-28
申请号：US12339841
申请日：2008-12-19
申请人： Peter Birk Rasmussen , Martin Roland Jensen , Klaus Gregorius Nielsen , Peter Koefoed , Florence Dal Degan
发明人： Peter Birk Rasmussen , Martin Roland Jensen , Klaus Gregorius Nielsen , Peter Koefoed , Florence Dal Degan
IPC分类号： A61K39/00 , A61K39/385 , A61K39/08 , A01K67/027 , C07K14/47
CPC分类号： A61K39/0007 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0312 , A61K39/385 , A61K45/06 , A61K2039/53 , A61K2039/6037 , A61K2039/6068 , A61K2039/6087 , A61K2039/6093 , A61K2039/64 , C07K14/4711 , Y02A50/412
摘要： Disclosed are novel methods and compositions for combating diseases characterized by deposition of amyloid. The methods generally rely on immunization against amyloid precursor protein (APP) or beta amyloid (Aβ). Immunization is preferably effected by administration of analogs of autologous APP or Aβ, said analogs being capable of inducing antibody production against the autologous amyloidogenic polypeptides. Especially preferred as an immunogen is autologous Aβ which has been modified by introduction of one single or a few foreign, immunodominant and promiscuous T-cell epitopes. Such methods and means include methods for the preparation of analogs and pharmaceutical formulations, as well as nucleic acid fragments, vectors, transformed cells, polypeptides and pharmaceutical formulations.
摘要翻译： 公开了用于防治以沉淀淀粉样蛋白为特征的疾病的新颖方法和组合物。 所述方法通常依赖于针对淀粉样前体蛋白（APP）或β淀粉样蛋白（A＆bgr）的免疫。 免疫优选通过施用自体APP或A＆bgr的类似物来实现;所述类似物能够诱导针对自体淀粉样蛋白形成多肽的抗体产生。 特别优选作为免疫原是自体A＆bgr; 其通过引入一种或几种外来的免疫显性和混杂的T细胞表位而被修饰。 这些方法和手段包括制备类似物和药物制剂以及核酸片段，载体，转化细胞，多肽和药物制剂的方法。
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公开(公告)号：US20100047262A1
公开(公告)日：2010-02-25
申请号：US12339841
申请日：2008-12-19
申请人： Peter Birk Rasmussen , Martin Roland Jensen , Klaus Gregorius Nielsen , Peter Koefoed , Florence Dal Degan
发明人： Peter Birk Rasmussen , Martin Roland Jensen , Klaus Gregorius Nielsen , Peter Koefoed , Florence Dal Degan
CPC分类号： A61K39/0007 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0312 , A61K39/385 , A61K45/06 , A61K2039/53 , A61K2039/6037 , A61K2039/6068 , A61K2039/6087 , A61K2039/6093 , A61K2039/64 , C07K14/4711 , Y02A50/412
摘要： Disclosed are novel methods and compositions for combating diseases characterized by deposition of amyloid. The methods generally rely on immunization against amyloid precursor protein (APP) or beta amyloid (Aβ). Immunization is preferably effected by administration of analogues of autologous APP or Aβ, said analogues being capable of inducing antibody production against the autologous amyloidogenic polypeptides. Especially preferred as an immunogen is autologous Aβ which has been modified by introduction of one single or a few foreign, immunodominant and promiscuous T-cell epitopes. Such methods and means include methods for the preparation of analogues and pharmaceutical formulations, as well as nucleic acid fragments, vectors, transformed cells, polypeptides and pharmaceutical formulations.
摘要翻译： 公开了用于防治以沉淀淀粉样蛋白为特征的疾病的新颖方法和组合物。 所述方法通常依赖于针对淀粉样前体蛋白（APP）或β淀粉样蛋白（A＆bgr）的免疫。 免疫优选通过施用自体APP或A＆bgr的类似物来实现;所述类似物能够诱导针对自体淀粉样变性多肽的抗体产生。 特别优选作为免疫原是自体A＆bgr; 其通过引入一种或几种外来的免疫显性和混杂的T细胞表位而被修饰。 这些方法和手段包括制备类似物和药物制剂以及核酸片段，载体，转化细胞，多肽和药物制剂的方法。
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公开(公告)号：US09249187B2
公开(公告)日：2016-02-02
申请号：US13146607
申请日：2010-01-26
CPC分类号： A61K39/39 , A61K2039/55516 , C07K7/08 , C07K2319/00
摘要： The present invention provides novel artificial oligopeptides capable of binding HLA Class II molecules encoded by several alleles. The oligopeptides include the sequence AX1FVAAX2TLX3AX4A (SEQ ID NO:1), wherein X1 is selected from the group consisting of W, F, Y, H, D, E, N, Q, I and K; X2 is selected from the group consisting of F, N, Y and W; X3 is selected from the group consisting of H and K, and X4 is selected from the group consisting of A, D and E, with the proviso that the oligopeptide sequence is not AKFVAAWTLKAAA. The invention also relates to larger peptides comprising the oligopeptides, polynucleotides encoding the oligopeptides and larger peptides, as well as to compositions comprising the oligopeptides, peptides or polynucleotides. Also disclosed are methods for inducing immune responses.
摘要翻译： 本发明提供能够结合由几个等位基因编码的HLA II类分子的新型人造寡肽。 寡肽包括序列AX1FVAAX2TLX3AX4A（SEQ ID NO：1），其中X1选自W，F，Y，H，D，E，N，Q，I和K; X2选自F，N，Y和W; X 3选自H和K，X 4选自A，D和E，条件是寡肽序列不是AKFVAAWTLKAAA。 本发明还涉及包含寡肽的较大肽，编码寡肽的多核苷酸和较大肽，以及包含寡肽，肽或多核苷酸的组合物。 还公开了诱导免疫应答的方法。
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公开(公告)号：US20110293646A1
公开(公告)日：2011-12-01
申请号：US13146607
申请日：2010-01-26
IPC分类号： A61K39/00 , C07K14/525 , C07K14/46 , C07K14/00 , C12N15/11 , A61P37/04 , C12N1/21 , C12N1/19 , C12N5/10 , C12N1/15 , A61K38/10 , C07K7/08 , C12N15/63
CPC分类号： A61K39/39 , A61K2039/55516 , C07K7/08 , C07K2319/00
摘要： The present invention provides novel artificial oligopeptides capable of binding HLA Class II molecules encoded by several alleles. The oligopeptides include the sequence AX1FVAAX2TLX3AX4A (SEQ ID NO:1), wherein X1 is selected from the group consisting of W, F, Y, H, D, E, N, Q, I and K; X2 is selected from the group consisting of F, N, Y and W; X3 is selected from the group consisting of H and K, and X4 is selected from the group consisting of A, D and E, with the proviso that the oligopeptide sequence is not AKFVAAWTLKAAA. The invention also relates to larger peptides comprising the oligopeptides, polynucleotides encoding the oligopeptides and larger peptides, as well as to compositions comprising the oligopeptides, peptides or polynucleotides. Also disclosed are methods for inducing immune responses.
摘要翻译： 本发明提供能够结合由几个等位基因编码的HLA II类分子的新型人造寡肽。 寡肽包括序列AX1FVAAX2TLX3AX4A（SEQ ID NO：1），其中X1选自W，F，Y，H，D，E，N，Q，I和K; X2选自F，N，Y和W; X 3选自H和K，X 4选自A，D和E，条件是寡肽序列不是AKFVAAWTLKAAA。 本发明还涉及包含寡肽的较大肽，编码寡肽的多核苷酸和较大肽，以及包含寡肽，肽或多核苷酸的组合物。 还公开了诱导免疫应答的方法。
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公开(公告)号：US20070184023A1
公开(公告)日：2007-08-09
申请号：US10577489
申请日：2004-10-28
IPC分类号： A61K39/385 , A61K38/21 , C07H21/04 , C07K14/475 , C12N1/15 , C12N1/21 , C12N15/63 , C12N15/74 , C12N15/79 , C12N5/04 , C12N5/06
CPC分类号： C07K14/52 , A61K38/00 , A61K39/00 , A61K47/61 , A61K47/6415 , A61K47/642 , Y02A50/412
摘要： The present invention provides for novel immunogenic variants of VEGF (vascular endothelial growth factor) which are useful in active specific immunotherapy against diseases that are characterized by overexpression of VEGF. The invention also relates to methods of treating such diseases (for instance cancer) as well as to various tools in molecular biology that assist in the provision of the immunogenic variants.
摘要翻译： 本发明提供VEGF（血管内皮生长因子）的新型免疫原性变体，其可用于针对以VEGF过表达为特征的疾病的活性特异性免疫疗法。 本发明还涉及治疗这些疾病（例如癌症）的方法以及有助于提供免疫原性变体的分子生物学中的各种工具。
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