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1.发明授权
公开(公告)号：US5258526A
公开(公告)日：1993-11-02
申请号：US843480
申请日：1992-02-28
IPC分类号： A01N43/36 , B01J23/44 , C07B61/00 , C07D207/34 , C07D317/46 , C07D405/04
CPC分类号： C07D405/04 , C07D207/34
摘要： A process for the preparation of 3-substituted 4-cyanopyrrole compounds of the formula (I) ##STR1## in which Ar has the meaning given in the description, by reaction in a 1st stage of bromides (II)Ar--Br (II)with acrylonitrile in the presence of a solvent and a suitable reaction auxiliary to give acrylonitrile derivatives (III)Ar--CH.dbd.CH--CN (III)and in a 2nd stage with a phenylsulphonylmethyl isocyanide (IV)Ph--SO.sub.2 --CH.sub.2 --CN (IV)in the presence of a solvent and optionally in the presence of a suitable reaction auxiliary, characterised in that the 1st stage is carried out in the presence of a palladium catalyst and the 2nd stage in the presence of a 1.2- to 1.8-fold molar excess of alkali metal alcoholate or alkali metal hydroxide.
摘要翻译： 其中Ar具有在描述中给出的含义，通过在溴化物（II）Ar-Br（II）的第一阶段中的反应制备式（I）所示的3-取代的4-氰基吡咯化合物的方法， 与丙烯腈在溶剂和适当的反应助剂存在下反应，得到丙烯腈衍生物（III）Ar-CH = CH-CN（III），第二阶段与苯基磺酰基甲基异氰化物（Ⅳ）Ph-SO2-CH2-CN（ IV）在溶剂存在下，任选地在合适的反应助剂的存在下，其特征在于第一阶段在钯催化剂存在下进行，第二阶段在1.2-1.8倍的存在下进行 过量的碱金属醇化物或碱金属氢氧化物。
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2.发明授权公开(公告)号：US06204397B1
公开(公告)日：2001-03-20
申请号：US08086602
申请日：1993-07-01
IPC分类号： C07D31752
CPC分类号： C07D317/46
摘要： A process for the preparation of 3-substituted 4-cyano-pyrrole compounds of the formula (I) in which Ar has the meaning given in the description, by reaction in a 1st stage of bromides (II) Ar—Br (II) with acrylonitrile in the presence of a solvent and a suitable reaction auxiliary to give acrylonitrile derivatives (III) Ar—CH═CH—CN (III) and in a 2nd stage with a phenylsulphonylmethyl isocyanide (IV) Ph—SO2—CH2—CN (IV) in the presence of a solvent and optionally in the presence of a suitable reaction auxiliary, characterised in that the the 1st stage is carried out in the presence of a palladium catalyst and the 2nd stage in the presence of a 1.2- to 1.8-fold molar excess of alkali metal alcoholate or alkali metal hydroxide.
摘要翻译： 制备式（I）的3-取代的4-氰基 - 吡咯化合物的方法，其中Ar具有在描述中给出的含义，通过在第一阶段的溴化物（II）与丙烯腈在溶剂存在下反应 和适当的反应助剂，在溶剂存在下，任选地在合适的反应助剂的存在下，在丙烯腈衍生物（III）中和在第二阶段中与苯基磺酰基甲基异氰化物（IV）反应，其特征在于携带第一阶段 在钯催化剂存在下进行，第二阶段在1.2至1.8倍摩尔过量的碱金属醇化物或碱金属氢氧化物的存在下进行。
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公开(公告)号：US5912354A
公开(公告)日：1999-06-15
申请号：US210321
申请日：1998-12-11
IPC分类号： C07D249/12
CPC分类号： C07D249/12
摘要： The present invention is related to an improved process for the commercial preparation of substituted aminotriazolinones, which are known intermediates in the preparation of herbicidal active compounds. In particular, this invention relates to the preparation of 4-amino-1,2,4-triazolin-5-ones, and more particularly to the preparation of 3-isopropyl-4-aminotriazolinone. The process of the invention includes reacting an oxadiazolinone with hydrazine hydrate in the absence of a solvent. In a preferred embodiment, the hydrazine hydrate is mixed with a basic compound, preferably aqueous sodium hydroxide.
摘要翻译： 本发明涉及商业上制备取代氨基三唑啉酮的改进方法，其是制备除草活性化合物的已知中间体。 特别地，本发明涉及4-氨基-1,2,4-三唑啉-5-酮的制备，更具体地说涉及3-异丙基-4-氨基三唑啉酮的制备。 本发明的方法包括在不存在溶剂的情况下使恶二唑啉酮与水合肼反应。 在优选的实施方案中，将水合肼与碱性化合物，优选氢氧化钠水溶液混合。
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公开(公告)号：US5440051A
公开(公告)日：1995-08-08
申请号：US216239
申请日：1994-03-22
申请人： Albrecht Marhold , Klaus Jelich
发明人： Albrecht Marhold , Klaus Jelich
IPC分类号： C07B39/00 , C07C41/22 , C07C43/174 , C07C43/225 , C07D307/82 , C07D317/46 , C07D319/20 , C07D319/14
CPC分类号： C07D317/46 , C07C41/22
摘要： Aryl ethers are chlorinated in the .alpha.-position by a process in which they are metered into a reaction vessel at the same time as chlorine, the reaction being carried out at temperatures in the range from 60.degree. to 150.degree. C.
摘要翻译： 芳基醚在α-位上被氯化，其中它们与氯同时计量加入反应容器中，反应在60-150℃的温度下进行。
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公开(公告)号：US5756752A
公开(公告)日：1998-05-26
申请号：US842585
申请日：1997-04-15
IPC分类号： C07C241/04 , C07C243/28 , C07D271/10 , C07D271/113 , C07D271/07 , C07B41/04 , C07C243/20
CPC分类号： C07D271/113 , C07C241/04
摘要： Substituted oxadiazolones of the formula (I) ##STR1## in which R represents optionally substituted alkyl, are obtained in good yields and high purity on reacting in a first step carboxylic acids of the general formula (II) R--COOH (II) with hydrazine hydrate in the presence of a catalyst and an inert diluent at temperatures between 0.degree. C. and 150.degree. C. with elimination of water and removal of said catalyst and reacting the resulting carboxylic hydrazides of the general formula (III) R--CO--NH--NH.sub.2 (III) in a second step with phosgene (COCl.sub.2) at temperatures between 20.degree. C. and 120.degree. C.
摘要翻译： 在通式（II）中，R-COOH（II）的第一步羧酸反应获得式（I）的取代的恶二唑酮，其中R表示任选取代的烷基，产率高，纯度高 ）与肼水合物在催化剂和惰性稀释剂存在下，在0℃至150℃之间的温度下，除去水并除去所述催化剂，并使所得的通式（III）的羧酰肼与R- CO-NH-NH 2（III）在第二步中与光气（COCl 2）在20℃至120℃之间。
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公开(公告)号：US5675010A
公开(公告)日：1997-10-07
申请号：US646671
申请日：1996-05-08
IPC分类号： C07D213/20 , C07D213/61
CPC分类号： C07D213/61
摘要： The present invention relates to new chloropyridinium chlorides of the general formula (I) ##STR1## in which R.sup.1 represents in each case optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkylalkyl, arylalkyl or heteroarylalkyl, R.sup.2 represents optionally substituted alkyl, and R.sup.3 represents hydrogen, halogen or optionally substituted alkyl, to a process for their preparation and to their use for the preparation of chloropyridines.
摘要翻译： 本发明涉及通式（I）的新的氯代吡啶鎓氯化物，其中R 1在每种情况下均为任选取代的烷基，烯基，炔基，环烷基，环烷基烷基，芳基烷基或杂芳基烷基，R 2表示任选取代的烷基， 并且R 3表示氢，卤素或任选取代的烷基，其制备方法及其用于制备氯吡啶的用途。
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公开(公告)号：US06211379B1
公开(公告)日：2001-04-03
申请号：US09488436
申请日：2000-01-20
IPC分类号： C07D41706
CPC分类号： C07D417/06
摘要： The present application relates to a process for preparing compounds of the formula (I) in which R1, A, X and Z are each as defined in the description by reacting compounds of the formula (II) in which A and X are each as defined in the description with compounds of the formula (III) in which Z, R1 and M1 are each as defined in the description.
摘要翻译： 本申请涉及一种制备式（I）化合物的方法，其中R 1，A，X和Z各自如说明书中所定义，通过使式（II）化合物（其中A和X各自如上所定义） 在其中Z，R 1和M 1各自如说明书中所定义的式（III）化合物的描述中。
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公开(公告)号：US5648495A
公开(公告)日：1997-07-15
申请号：US584867
申请日：1996-01-11
IPC分类号： C07B37/10 , C07D213/61
CPC分类号： C07D213/61
摘要： The present invention relates to a process for the preparation of 5-substituted 2-chloropyridines of the formula (I) ##STR1## by reaction of acetenamides of the formula (II) ##STR2## with Vilsmeier reagent, which is prepared by reaction of dialkylformamides of the formula (III) ##STR3## with a chlorinating agent, the excess of which is removed from the reaction mixture by distillation or by addition of dialkylformamide after completion of the reaction of the Vilsmeier reagent with the acetenamide of the formula (II), wherein in the formulae (I)-(III):R represents optionally substituted alkyl or aralkyl,R.sup.1 represents C.sub.1 -C.sub.4 -alkyl or aryl-C.sub.1 -C.sub.4 -alkyl,R.sup.2 and R.sup.3 represent straight-chain, branched or cyclic C.sub.4 -C.sub.8 -alkyl.
摘要翻译： 本发明涉及通过式（Ⅱ）的乙酰胺与Vilsmeier试剂的反应制备式（Ⅰ）的（I）的5-取代的2-氯吡啶的方法，其中 通过式（Ⅲ）的二烷基甲酰胺与氯化剂反应来制备，其中过氯化物通过蒸馏或通过加入二烷基甲酰胺从反应混合物中除去，该反应混合物在Vilsmeier试剂与 式（II）的乙酰胺，其中在式（I） - （III）中：R表示任选取代的烷基或芳烷基，R 1表示C 1 -C 4 - 烷基或芳基-C 1 -C 4 - 烷基，R 2和R 3表示直链 链，支链或环状C 4 -C 8 - 烷基。
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公开(公告)号：US5541332A
公开(公告)日：1996-07-30
申请号：US368179
申请日：1995-01-04
IPC分类号： C07D213/20 , C07D213/61
CPC分类号： C07D213/61
摘要： A process for the preparation of a chloropyridine of the formula ##STR1## which comprises reacting an enamide of the formula ##STR2## with a chlorinating agent in the presence of a di-substituted formamide ##STR3## in which R.sup.4 and R.sup.5 each individually is alkyl or cycloalkyl or together are alkanediyl, at a temperature between about -30.degree. C. and 100.degree. C., thereby to produce a compound of the formula ##STR4## and subjecting said compound to thermal cleavage. Compounds I are novel. Compounds IV are known intermediates for agrochemicals and pharmaceuticals.
摘要翻译： （IV）的氯吡啶的制备方法，其包括在二取代的甲酰胺（III）的存在下使式（I）的酰胺与氯化剂反应， 其中R 4和R 5各自独立地是烷基或环烷基或一起是烷二基，在约-30℃至100℃的温度下，从而产生下式化合物（I），并使所述化合物 热裂解。 化合物I是新的。 化合物IV是农药和药物的已知中间体。
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公开(公告)号：US5103011A
公开(公告)日：1992-04-07
申请号：US644702
申请日：1991-01-23
IPC分类号： C07D213/61
CPC分类号： C07D213/61
摘要： In the preparation of 2-chloro-5-methyl-pyridine of the formula ##STR1## by reacting 3-methyl-pyridine-1-oxide of the formula ##STR2## with a chlorinating agent, the improvement which comprises effecting the reaction in the presence of a chlorinating agent of the formula ##STR3## in which A represents oxygen or the grouping ##STR4## in which R.sup.2 and R.sup.3 individually represent alkyl, cycloalkyl or aryl or together represent alkanediyl or oxaalkanediyl andR.sup.1 represents hydrogen, chlorine, alkyl, cycloalkyl, aryl or the grouping ##STR5## in which R.sup.2 and R.sup.3 have the abovementioned meanings,and where, if R.sup.1 represents aryl, A must represent the grouping ##STR6## in the presence of a basic organic nitrogen compound and in the presence of a diluent at a temperature between about -20.degree. C. and +120.degree. C. The product is known to be useful in the systhesis of pharmaceuticals and insecticides.
摘要翻译： 在通式（Ⅰ）的3-甲基 - 吡啶-1-氧化物与氯化剂反应制备式（Ⅰ）的2-氯-5-甲基 - 吡啶时，其改进是 包括在其中A表示氧的分子式（III）的氯化剂或其中R 2和R 3各自表示烷基，环烷基或芳基或一起代表烷二基或氧杂烷二基的基团的组合
的存在下进行反应，以及 R 1表示氢，氯，烷基，环烷基，芳基或其中R 2和R 3具有上述含义的基团，其中，如果R 1表示芳基，则A在碱性有机物存在下必须代表“IMAGE” 氮化合物和稀释剂存在下，在约-20℃至+ 120℃之间的温度下进行。已知该产物可用于药物和杀虫剂的合成。
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