Protein-based conjugates and self-assembled nanostructures
    3.
    发明授权
    Protein-based conjugates and self-assembled nanostructures 有权
    基于蛋白质的缀合物和自组装纳米结构

    公开(公告)号:US09359457B2

    公开(公告)日:2016-06-07

    申请号:US13882035

    申请日:2011-10-26

    摘要: The present disclosure provides protein-containing compositions, methods and uses thereof. A conjugate comprises a globular protein conjugated with a polymer that preserves the folded and functional structure of a protein. In some embodiments, a fusion protein comprises a globular protein conjugated with an elastin-mimic polymer (EMP). Also disclosed is an assembled solid-state or gel-state nanostructure comprising a plurality of conjugates, wherein each comprises a globular protein conjugated with a polymer that preserving the folded and functional structure of a protein. In certain embodiments, provided compositions and methods further comprise an additive.

    摘要翻译: 本公开提供含蛋白质的组合物,其方法和用途。 缀合物包含与保留蛋白质的折叠和功能结构的聚合物缀合的球状蛋白质。 在一些实施方案中,融合蛋白包含与弹性蛋白模拟聚合物(EMP)缀合的球状蛋白。 还公开了包含多个缀合物的组装的固态或凝胶态纳米结构,其中每个包含与保持蛋白质的折叠和功能结构的聚合物共轭的球状蛋白。 在某些实施方案中,所提供的组合物和方法还包含添加剂。

    PROTEIN-BASED CONJUGATES AND SELF-ASSEMBLED NANOSTRUCTURES
    4.
    发明申请
    PROTEIN-BASED CONJUGATES AND SELF-ASSEMBLED NANOSTRUCTURES 有权
    蛋白质结合和自组装纳米结构

    公开(公告)号:US20130280782A1

    公开(公告)日:2013-10-24

    申请号:US13882035

    申请日:2011-10-26

    IPC分类号: C08F20/56 C12N9/96

    摘要: The present disclosure provides protein-containing compositions, methods and uses thereof. A conjugate comprises a globular protein conjugated with a polymer that preserves the folded and functional structure of a protein. In some embodiments, a fusion protein comprises a globular protein conjugated with an elastin-mimic polymer (EMP). Also disclosed is an assembled solid-state or gel-state nanostructure comprising a plurality of conjugates, wherein each comprises a globular protein conjugated with a polymer that preserving the folded and functional structure of a protein. In certain embodiments, provided compositions and methods further comprise an additive.

    摘要翻译: 本公开提供含蛋白质的组合物,其方法和用途。 缀合物包含与保留蛋白质的折叠和功能结构的聚合物缀合的球状蛋白质。 在一些实施方案中,融合蛋白包含与弹性蛋白模拟聚合物(EMP)缀合的球状蛋白。 还公开了包含多个缀合物的组装的固态或凝胶态纳米结构,其中每个包含与保持蛋白质的折叠和功能结构的聚合物共轭的球状蛋白。 在某些实施方案中,所提供的组合物和方法还包含添加剂。