公开(公告)号：US20060189893A1

公开(公告)日：2006-08-24

申请号：US11318123

申请日：2005-12-23

申请人： Warren Maltzman ,  Peter Gombrich ,  Eugene Dimonte ,  Edward Eaton ,  Eric Larson

发明人： Warren Maltzman ,  Peter Gombrich ,  Eugene Dimonte ,  Edward Eaton ,  Eric Larson

IPC分类号： A61B10/00

CPC分类号： A61B10/0045 ,  A61B2010/0074

摘要： Systems and methods of interrogating clusters of cells for two or more biological markers that do not, or rarely, occur in the same cell during normal cellular growth, development and function, to indicate the existence of cells that are part of a local area where a pre-neoplastic or neoplastic lesion may be present. The relationship among cells is maintained while interrogating the clusters of cells to facilitate the examination and determination of the existence of possible dysplasia.

摘要翻译： 询问两个或多个生物标记物的细胞簇的系统和方法，其在正常细胞生长，发育和功能期间不会或很少发生在相同细胞中，以指示作为局部区域的一部分的细胞的存在，其中 可能存在肿瘤前或肿瘤前病变。 在询问细胞簇时，保持细胞之间的关系，以便于检查和确定可能的发育不良的存在。

公开(公告)号：US20060161076A1

公开(公告)日：2006-07-20

申请号：US11318025

申请日：2005-12-23

申请人： Peter Gombrich ,  Eugene Dimonte ,  Edward Eaton ,  Eric Larson

发明人： Peter Gombrich ,  Eugene Dimonte ,  Edward Eaton ,  Eric Larson

IPC分类号： A61B10/00

CPC分类号： A61B10/02 ,  A61B10/00 ,  A61B2010/0074

摘要： A cell collector and cell collection method are provided for collecting clusters of cells for subsequent analysis of the cells to screen for abnormalities. The cell collector is designed to enhance the capability of the collector to pick-up clusters or clumps of cells, and to facilitate transfer of the collected clusters of cells onto a receiving structure, for example a slide. In one embodiment, a combination of the material of the collector, the texture of the collection surface of the collector, and the use of expansion and rotation of the collector during collection facilitate the collection of the clusters of cells.

摘要翻译： 提供细胞收集器和细胞收集方法用于收集细胞簇以便随后分析细胞以筛选异常。 细胞收集器被设计成增强收集器拾取细胞簇或聚集体的能力，并且有助于将收集的细胞簇转移到接收结构例如载玻片上。 在一个实施例中，收集器的材料，收集器的收集表面的纹理以及在收集器期间收集器的膨胀和旋转的使用的组合有利于收集细胞簇。

公开(公告)号：US07838215B2

公开(公告)日：2010-11-23

申请号：US12211547

申请日：2008-09-16

申请人： Peter Gombrich ,  Mitchell Golbus

发明人： Peter Gombrich ,  Mitchell Golbus

IPC分类号： C12Q1/70

CPC分类号： G01N33/57411 ,  C07K14/005 ,  C07K16/084 ,  C12N7/00 ,  C12N2710/20022 ,  G01N33/56983 ,  G01N2333/025

摘要： Advanced cervical cancer screening methods that provide a molecular based process of detecting HPV-integration. The disclosed methods allow for a streamlined approach of conducting a Pap test and immunohistochemical test on the same slide. The disclosed methods provides an inexpensive, highly sensitive, specific, and detailed test that is easy to evaluate and follow-up.

摘要翻译： 先进的宫颈癌筛查方法，提供检测HPV整合的基于分子的过程。 所公开的方法允许在同一载玻片上进行Pap测试和免疫组织化学测试的流线型方法。 所公开的方法提供了便宜的，高度灵敏的，特定的和详细的测试，其易于评估和跟踪。

公开(公告)号：US20230049594A1

公开(公告)日：2023-02-16

申请号：US17402498

申请日：2021-08-13

申请人： Peter Gombrich

发明人： Peter Gombrich

IPC分类号： B65D83/00 ,  B01F13/00

摘要： In one aspect, the invention provides a fluid dispenser comprising a housing configured to receive a means for pressurizing and a disposable fluid bag, and a nozzle towards a distal end. A means for flow control comprising a tubular body whose longitudinal axis coincides with the longitudinal axis of the nozzle having a diameter that tapers from the side distal to the nozzle towards the nozzle is provided. The tubular body is configured to move along its longitudinal axis such that a volume of a gap between the tubular body and the nozzle is varied thus controlling the flow rate. Further, an adapter configured to be fitted onto the nozzle capable of receiving at least one applicator is provided. The fluid dispenser of the invention is capable of being used in a variety of situations in a facile manner, replacing several different devices to be used for individual applications.