公开(公告)号：US08007646B2

公开(公告)日：2011-08-30

申请号：US12505859

申请日：2009-07-20

申请人： Robert A. Edwards ,  Raymond J. Turner ,  Carol Ladner ,  Jean Starkey ,  Eric Larson ,  Dmitri Kazmin

发明人： Robert A. Edwards ,  Raymond J. Turner ,  Carol Ladner ,  Jean Starkey ,  Eric Larson ,  Dmitri Kazmin

IPC分类号： G01N27/453

CPC分类号： G01N33/6827

摘要： The mechanism of the UV light-induced reaction between the indole moiety of tryptophan and chloroform, and the structure of the modified tryptophan and polypeptides including such modified tryptophan residues. The excited indole moiety, which is formed upon UV light irradiation, emits a solvated electron which initiates a series of events that yield fluorescent derivatives that have CHO group covalently bound to the indole moiety. These derivatives are herein referred to as formyltryptophan, and are relatively stable. Similar reactions are observed when 5-hydroxytryptophan, 5-fluorotryptophan, or N-methylindolacetate are used in place of tryptophan, or when other haloalkanes, such as trichloracetic acid, trichlorethanol, trichlorethane, bromoform, and iodoactetate are used in place of chloroform. The derivatives can be used in a variety of applications in fluorescence spectroscopy, and for nuclear magnetic resonance, X-ray crystallography, infra-red spectroscopy, circular dicroism and mass spectroscopy. Additionally, the UV light-induced reaction between the indole moiety of tryptophan and haloalkanes can be used to prepare derivatives of tryptophan for chemical cross-linking studies of proteins and peptides.

摘要翻译： 色氨酸和氯仿的吲哚部分之间的UV光诱导反应的机理，以及修饰的色氨酸和多肽的结构，包括这些修饰的色氨酸残基。 在UV光照射下形成的激发的吲哚部分发射溶剂化电子，其引发一系列事件，其产生具有与吲哚部分共价结合的CHO基团的荧光衍生物。 这些衍生物在本文中称为甲酰色氨酸，并且相对稳定。 当使用5-羟色氨酸，5-氟色氨酸或N-甲基吲哚乙酸乙酯代替色氨酸时，或当使用其它卤代烷烃如三氯乙酸，三氯乙醇，三氯乙烷，溴仿和碘代酸酯代替氯仿时，可以观察到类似的反应。 衍生物可用于荧光光谱学，核磁共振，X射线晶体学，红外光谱，圆形微球和质谱等多种应用。 此外，色氨酸和卤代烷烃的吲哚部分之间的紫外光诱导反应可用于制备色氨酸的衍生物用于蛋白质和肽的化学交联研究。

公开(公告)号：US07722699B2

公开(公告)日：2010-05-25

申请号：US12325121

申请日：2008-11-28

申请人： Lee Pendleton Morgan ,  Jan Eric Larson

发明人： Lee Pendleton Morgan ,  Jan Eric Larson

IPC分类号： B01D46/04 ,  B01D46/52

CPC分类号： B01D46/523 ,  B01D46/0068 ,  B01D46/2411 ,  B01D46/44 ,  B01D2265/06

摘要： An adaptable dual direction, differential pressure assembly is disclosed. Solenoid valves release controlled bursts of air into a top of a container. A rate of the controlled bursts of air is partially responsive to a pressure differential between atmospheric pressure and that of compressed air in the reservoir. A pleated filter is fitted inside of the container. The pleated filter has an inner wall and an outer wall and has pleatings separated using hot melt glue beads there between. The controlled bursts of air are programmed to be substantially automatically responsive to one or more pressure differentials between an inner wall and an outer wall. In one embodiment, air is drawn from the blower through the pleated filter from the inner wall to the outer wall until a desired pressure differential is achieved. In yet another embodiment, air is drawn through the pleated filter from the outer wall into the inner wall and to draw upwardly out of the top of the container through the blower until a first pressure differential is achieved.

摘要翻译： 公开了一种适应性的双向，差压组件。 电磁阀将控制爆发的空气释放到容器的顶部。 受控的空气爆发的速率部分地响应于大气压力与储层中的压缩空气压力之差。 打褶过滤器装在容器的内部。 褶皱过滤器具有内壁和外壁，并且在其间具有使用热熔胶珠分离的褶皱。 控制的空气脉冲被编程为基本上自动地响应于内壁和外壁之间的一个或多个压力差。 在一个实施例中，从鼓风机通过打褶过滤器将空气从内壁抽吸到外壁，直至实现所需的压力差。 在另一个实施例中，空气通过打褶过滤器从外壁进入内壁，并通过鼓风机从容器的顶部向上拉出直到达到第一压力差。

公开(公告)号：US07585609B2

公开(公告)日：2009-09-08

申请号：US11492276

申请日：2006-07-25

申请人： Carl Eric Larson ,  Gregory Michael Wallraff

发明人： Carl Eric Larson ,  Gregory Michael Wallraff

IPC分类号： G03F7/11 ,  G03F7/09 ,  G03F7/095

CPC分类号： G03F7/095 ,  G03F7/0382 ,  G03F7/0392 ,  G03F7/094

摘要： The present invention provides methods for forming images in positive- or negative-tone chemically amplified photoresists. The methods of the present invention rely on the vertical up-diffusion of photoacid generated by patternwise imaging of an underlayer disposed on a substrate and overcoated with a polymer containing acid labile functionality. In accordance with the present invention, the vertical up-diffusion can be the sole mechanism for imaging formation or the methods of the present invention can be used in conjunction with conventional imaging processes.

摘要翻译： 本发明提供了在正或负色调化学放大的光致抗蚀剂中形成图像的方法。 本发明的方法依赖于通过对设置在基底上的底层的图案成像产生的光酸的垂直向上扩散，并且用含有酸不稳定性功能的聚合物涂覆。 根据本发明，垂直向上扩散可以是用于成像成像的唯一机构，或者本发明的方法可以与传统的成像过程结合使用。

公开(公告)号：US20090105610A1

公开(公告)日：2009-04-23

申请号：US12339870

申请日：2008-12-19

申请人： Peter GOMBRICH ,  Eugene DIMONTE ,  Edward EATON ,  Eric LARSON

发明人： Peter GOMBRICH ,  Eugene DIMONTE ,  Edward EATON ,  Eric LARSON

IPC分类号： A61B10/00

CPC分类号： A61B10/02 ,  A61B10/00 ,  A61B2010/0074

摘要： A cell collector and cell collection method are provided for collecting clusters of cells for subsequent analysis of the cells to screen for abnormalities. The cell collector is designed to enhance the capability of the collector to pick-up clusters or clumps of cells, and to facilitate transfer of the collected clusters of cells onto a receiving structure, for example a slide. In one embodiment, a combination of the material of the collector, the texture of the collection surface of the collector, and the use of expansion and rotation of the collector during collection facilitate the collection of the clusters of cells.

摘要翻译： 提供细胞收集器和细胞收集方法用于收集细胞簇以便随后分析细胞以筛选异常。 细胞收集器被设计成增强收集器拾取细胞簇或聚集体的能力，并且有助于将收集的细胞簇转移到接收结构例如载玻片上。 在一个实施例中，收集器的材料，收集器的收集表面的纹理以及在收集器期间收集器的膨胀和旋转的使用的组合有利于收集细胞簇。

公开(公告)号：US20090078116A1

公开(公告)日：2009-03-26

申请号：US12325121

申请日：2008-11-28

申请人： Lee Pendleton Morgan ,  Jan Eric Larson

发明人： Lee Pendleton Morgan ,  Jan Eric Larson

IPC分类号： B01D46/46

CPC分类号： B01D46/523 ,  B01D46/0068 ,  B01D46/2411 ,  B01D46/44 ,  B01D2265/06

摘要： An adaptable dual direction, differential pressure assembly is disclosed. Solenoid valves release controlled bursts of air into a top of a container. A rate of the controlled bursts of air is partially responsive to a pressure differential between atmospheric pressure and that of compressed air in the reservoir. A pleated filter is fitted inside of the container. The pleated filter has an inner wall and an outer wall and has pleatings separated using hot melt glue beads there between. The controlled bursts of air are programmed to be substantially automatically responsive to one or more pressure differentials between an inner wall and an outer wall. In one embodiment, air is drawn from the blower through the pleated filter from the inner wall to the outer wall until a desired pressure differential is achieved. In yet another embodiment, air is drawn through the pleated filter from the outer wall into the inner wall and to draw upwardly out of the top of the container through the blower until a first pressure differential is achieved.

摘要翻译： 公开了一种适应性的双向，差压组件。 电磁阀将控制爆发的空气释放到容器的顶部。 受控的空气爆发的速率部分地响应于大气压力与储层中的压缩空气压力之差。 打褶过滤器装在容器的内部。 褶皱过滤器具有内壁和外壁，并且在其间具有使用热熔胶珠分离的褶皱。 控制的空气脉冲被编程为基本上自动地响应于内壁和外壁之间的一个或多个压力差。 在一个实施例中，从鼓风机通过打褶过滤器将空气从内壁抽吸到外壁，直至实现所需的压力差。 在另一个实施例中，空气通过打褶过滤器从外壁进入内壁，并通过鼓风机从容器的顶部向上拉出直到达到第一压力差。

公开(公告)号：US20070214968A1

公开(公告)日：2007-09-20

申请号：US11384893

申请日：2006-03-20

申请人： Eric Larson ,  Edward Eaton ,  Eugene DiMonte

发明人： Eric Larson ,  Edward Eaton ,  Eugene DiMonte

IPC分类号： A47J37/12

CPC分类号： A47J37/1295

摘要： A fry basket includes an open top basket frame having a plurality of upright side walls defining a frying space therewithin. One side of the basket frame is positionable on a support structure above a food receiving station. At least one perforate trap door is movably mounted on the basket frame for movement between a closed position closing a drop opening at the bottom of the frame and an open position to allow cooked food to drop through the opening onto the food receiving station. Actuating means are provided for automatically moving the trap door from its closed to its open position simply in response to moving the basket frame relative to the support structure.

摘要翻译： 油炸篮包括开放的顶部篮框架，其具有限定其中的油炸空间的多个直立侧壁。 篮框架的一侧可定位在食物接收台上方的支撑结构上。 至少一个穿孔捕捉门可移动地安装在篮架上，用于在关闭位于框架底部的落下开口的关闭位置和打开位置之间移动，以允许熟食通过开口落入食物接收站。 提供致动装置，用于响应于相对于支撑结构移动篮架，自动将收集门从其关闭位置移动到其打开位置。

公开(公告)号：US20070146115A1

公开(公告)日：2007-06-28

申请号：US11705362

申请日：2007-02-12

申请人： Philipp Roosli ,  Eric Larson ,  Ravi Sagar

发明人： Philipp Roosli ,  Eric Larson ,  Ravi Sagar

IPC分类号： G05B19/00

CPC分类号： G07C9/00904 ,  E05B47/00 ,  E05B2047/0057 ,  E05B2047/0065 ,  E05B2047/0068 ,  G07C9/00103 ,  G07C9/00182 ,  G07C9/00571 ,  G07C9/00658 ,  G07C9/00944 ,  G07C2009/00634 ,  G07C2009/00642

摘要： A power management lock system including an electronic lock unit configured to lock and unlock a door and further including at least one sensor in communication with the electronic lock unit, the sensor configured to sense an open condition of the door and a closed condition of the door, wherein the electronic lock unit is configured to receive door data pertaining to the open condition and the closed condition from the at least one sensor, and where the electronic lock unit is further configured to manage the provision of power within the electronic unit based upon the door data.

摘要翻译： 一种电源管理锁定系统，包括被配置为锁定和解锁门并且进一步包括与电子锁定单元通信的至少一个传感器的电子锁定单元，所述传感器构造成感测门的打开状态和门的关闭状态 ，其中所述电子锁定单元被配置为从所述至少一个传感器接收关于所述打开状态和所述关闭状态的门数据，并且其中所述电子锁定单元还被配置为基于所述电子单元管理所述电子单元内的电力供应 门数据

公开(公告)号：US20060207988A1

公开(公告)日：2006-09-21

申请号：US11242629

申请日：2005-10-03

申请人： Eric Larson ,  Juan Barrena

发明人： Eric Larson ,  Juan Barrena

IPC分类号： H05B1/02

CPC分类号： F24C15/106 ,  H05B1/0266

摘要： A user control generates a heat level input signal responsive to a user of a cooktop heating element. Logic generates an output signal having a duty cycle corresponding to the input signal. An electromechanical device connected to apply power from a source to the heating element in response to the output signal.

摘要翻译： 用户控制响应于炉灶加热元件的使用者产生热量输入信号。 逻辑产生具有对应于输入信号的占空比的输出信号。 连接的机电装置，用于响应于输出信号将来自源的功率施加到加热元件。

公开(公告)号：US20060189893A1

公开(公告)日：2006-08-24

申请号：US11318123

申请日：2005-12-23

申请人： Warren Maltzman ,  Peter Gombrich ,  Eugene Dimonte ,  Edward Eaton ,  Eric Larson

发明人： Warren Maltzman ,  Peter Gombrich ,  Eugene Dimonte ,  Edward Eaton ,  Eric Larson

IPC分类号： A61B10/00

CPC分类号： A61B10/0045 ,  A61B2010/0074

摘要： Systems and methods of interrogating clusters of cells for two or more biological markers that do not, or rarely, occur in the same cell during normal cellular growth, development and function, to indicate the existence of cells that are part of a local area where a pre-neoplastic or neoplastic lesion may be present. The relationship among cells is maintained while interrogating the clusters of cells to facilitate the examination and determination of the existence of possible dysplasia.

摘要翻译： 询问两个或多个生物标记物的细胞簇的系统和方法，其在正常细胞生长，发育和功能期间不会或很少发生在相同细胞中，以指示作为局部区域的一部分的细胞的存在，其中 可能存在肿瘤前或肿瘤前病变。 在询问细胞簇时，保持细胞之间的关系，以便于检查和确定可能的发育不良的存在。

公开(公告)号：US20060042891A1

公开(公告)日：2006-03-02

申请号：US11213333

申请日：2005-08-26

申请人： Eric Larson ,  Fredric Biddle ,  Austin Cliffe ,  Ben Shao

发明人： Eric Larson ,  Fredric Biddle ,  Austin Cliffe ,  Ben Shao

IPC分类号： F16D65/14

CPC分类号： A61G5/02 ,  A61G5/1054 ,  A61G5/1072 ,  A61G5/1075

摘要： One embodiment of the present invention includes a technique to manually propel movement of a wheelchair in a first direction while being carried by the wheelchair. This wheelchair includes a first wheel with a first brake and a second wheel with a second brake. While participating in a sports activity with one or more hands during this movement, steering the wheelchair in a second direction by hands-free activation of the first brake and in a third direction by hands-free activation of the second brake; and stopping the movement of the wheelchair by hands-free activation of the first brake and the second brake.

摘要翻译： 本发明的一个实施例包括一种在由轮椅携带的情况下手动推动轮椅在第一方向上的运动的技术。 该轮椅包括具有第一制动器的第一轮和具有第二制动器的第二轮。 当在该运动期间参与一只或多只手的运动活动时，通过用第一制动器的免手动作并且在第三方向上通过第二制动器的免提启动来使轮椅在第二方向上转向; 并通过第一制动器和第二制动器的免提启动来停止轮椅的移动。