公开(公告)号：US20050137215A1

公开(公告)日：2005-06-23

申请号：US10822615

申请日：2004-04-12

申请人： Peter Guzzo ,  James Hamby ,  Matthew Johnson ,  Van-Duc Le ,  John Mangette ,  Rajesh Shenoy ,  Michael Stier

发明人： Peter Guzzo ,  James Hamby ,  Matthew Johnson ,  Van-Duc Le ,  John Mangette ,  Rajesh Shenoy ,  Michael Stier

IPC分类号： A61K31/4035 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/519 ,  A61P19/02 ,  C07D209/44 ,  C07D209/94 ,  C07D409/04 ,  C07D413/02 ,  C07D413/04 ,  C07D417/02 ,  C07D419/04 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D493/04 ,  C07D495/04 ,  C07D513/14

CPC分类号： C07D471/04 ,  C07D209/44 ,  C07D209/94 ,  C07D409/04 ,  C07D413/04 ,  C07D419/04 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  C07D513/14

摘要： This invention relates to a compound which is [c]-fused bicyclic proline derivative, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition comprising the compound or the salt thereof, and methods of treating diseases, including, but not limited to, methods of preventing or inhibiting joint cartilage damage and preventing or treating diseases characterized by joint cartilage damage, joint inflammation, or joint pain. The [c]-fused bicyclic proline derivatives are compounds of Formula I as described above. Diseases characterized by joint cartilage damage or joint pain include, for example, osteoarthritis and rheumatoid arthritis. Rheumatoid arthritis is also characterized by joint inflammation. This invention also relates to methods of synthesizing and preparing the [c]-fused bicyclic proline derivatives, or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明涉及[c]双环脯氨酸衍生物或其药学上可接受的盐的化合物; 包含该化合物或其盐的药物组合物，以及治疗疾病的方法，包括但不限于预防或抑制关节软骨损伤和预防或治疗以关节软骨损伤，关节炎症或关节疼痛为特征的疾病的方法。 [c]引入的双环脯氨酸衍生物是如上所述的式I化合物。 以关节软骨损伤或关节疼痛为特征的疾病包括例如骨关节炎和类风湿性关节炎。 类风湿性关节炎的特征还在于关节炎。 本发明还涉及合成和制备[c]引入的双环脯氨酸衍生物或其药学上可接受的盐的方法。

公开(公告)号：US20050143427A1

公开(公告)日：2005-06-30

申请号：US10822389

申请日：2004-04-12

申请人： Nicole Barvian ,  Cleo Connolly ,  Peter Guzzo ,  James Hamby ,  James Hicks ,  Matthew Johnson ,  Van-Duc Le ,  Lorna Mitchell ,  William Roark

发明人： Nicole Barvian ,  Cleo Connolly ,  Peter Guzzo ,  James Hamby ,  James Hicks ,  Matthew Johnson ,  Van-Duc Le ,  Lorna Mitchell ,  William Roark

IPC分类号： A61P19/00 ,  C07D209/12 ,  C07D209/14 ,  C07D403/04 ,  C07D413/04 ,  C07D417/02 ,  C07D495/04 ,  A61K31/433 ,  A61K31/4245 ,  C07D413/02

CPC分类号： C07D495/04 ,  C07D209/12 ,  C07D209/14 ,  C07D403/04 ,  C07D413/04 ,  C07D417/02

摘要： This invention relates to a compound which is [b]-fused bicyclic proline derivative, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition comprising the compound or the salt thereof, and methods of treating diseases, including, but not limited to, methods of preventing or inhibiting joint cartilage damage and preventing or treating diseases characterized by joint cartilage damage, joint inflammation, or joint pain. The [b]-fused bicyclic proline derivatives are compounds of Formula I as described above. Diseases characterized by joint cartilage damage or joint pain include, for example, osteoarthritis and rheumatoid arthritis. Rheumatoid arthritis is also characterized by joint inflammation. This invention also relates to methods of synthesizing and preparing the [b]-fused bicyclic proline derivatives, or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明涉及[b]双环脯氨酸衍生物或其药学上可接受的盐的化合物; 包含该化合物或其盐的药物组合物和治疗疾病的方法，包括但不限于预防或抑制关节软骨损伤和预防或治疗以关节软骨损伤，关节炎症或关节疼痛为特征的疾病的方法。 [b]引发的双环脯氨酸衍生物是如上所述的式I化合物。 以关节软骨损伤或关节疼痛为特征的疾病包括例如骨关节炎和类风湿性关节炎。 类风湿性关节炎的特征还在于关节炎。 本发明还涉及合成和制备[b] - 双环脯氨酸衍生物或其药学上可接受的盐的方法。

公开(公告)号：US20090084882A1

公开(公告)日：2009-04-02

申请号：US11862670

申请日：2007-09-27

申请人： Daniel WILLIAMS ,  James Hamby

发明人： Daniel WILLIAMS ,  James Hamby

IPC分类号： B21C47/02 ,  B21C47/32 ,  B65D63/12

CPC分类号： B65D85/04 ,  B65D63/1063 ,  Y10T24/1498

摘要： A device and method for coiling a long, slender, flexible material (e.g., an electrical cable). One embodiment of the device includes (1) a cylinder defining a substantially cylindrical exterior surface and (2) a reel, around which the flexible material can be coiled. The substantially cylindrical exterior surface defines a groove for receiving at least part of an open tie (e.g., cable tie), and the reel defines an axial through-opening for removably receiving the cylinder therethrough.

摘要翻译： 用于卷绕长而细长的柔性材料（例如，电缆）的装置和方法。 该装置的一个实施例包括（1）限定基本上圆柱形外表面的圆柱体和（2）卷轴，柔性材料围绕该卷轴被卷绕。 基本上圆柱形的外表面限定用于容纳至少一部分开式连接带（例如电缆扎带）的凹槽，并且所述卷轴限定一个轴向通孔，用于通过其可移除地容纳所述圆筒。

公开(公告)号：US20130338372A1

公开(公告)日：2013-12-19

申请号：US13533606

申请日：2012-06-26

申请人： Jetze Tepe ,  James Hamby

发明人： Jetze Tepe ,  James Hamby

IPC分类号： C07D233/28

CPC分类号： C07D233/28

摘要： The invention relates to compositions comprising substituted imidazoline compounds including prodrugs, and salts thereof. In some embodiments, the invention relates to the use of these compositions as therapeutic agents, preferably for the treatment of arthritis or cancer. In further embodiments, The invention relates to the pharmaceutical compositions with effective amounts of substituted imidazoline compounds disclosed herein that function as agonist or antagonists of the genetic expression or interactions with transcription factor NF-κB.

公开(公告)号：US08252942B2

公开(公告)日：2012-08-28

申请号：US12247524

申请日：2008-10-08

申请人： Jetze Tepe ,  James Hamby

发明人： Jetze Tepe ,  James Hamby

IPC分类号： C07D233/22

CPC分类号： C07D233/28

摘要： The invention relates to compositions comprising substituted imidazoline compounds including prodrugs, and salts thereof. In some embodiments, the invention relates to the use of these compositions as therapeutic agents, preferably for the treatment of arthritis or cancer. In further embodiments, The invention relates to the pharmaceutical compositions with effective amounts of substituted imidazoline compounds disclosed herein that function as agonist or antagonists of the genetic expression or interactions with transcription factor NF-κB.

摘要翻译： 本发明涉及包含取代的咪唑啉化合物（包括前药）及其盐的组合物。 在一些实施方案中，本发明涉及这些组合物作为治疗剂的用途，优选用于治疗关节炎或癌症。 在进一步的实施方案中，本发明涉及具有有效量的本文公开的取代的咪唑啉化合物的药物组合物，其作为与转录因子NF-κB的遗传表达或相互作用的激动剂或拮抗剂。

公开(公告)号：US20090156830A1

公开(公告)日：2009-06-18

申请号：US12247524

申请日：2008-10-08

申请人： Jetze Tepe ,  James Hamby

发明人： Jetze Tepe ,  James Hamby

IPC分类号： C07D233/28 ,  C07D233/22 ,  C07D233/24

CPC分类号： C07D233/28

摘要： The invention relates to compositions comprising substituted imidazoline compounds including prodrugs, and salts thereof. In some embodiments, the invention relates to the use of these compositions as therapeutic agents, preferably for the treatment of arthritis or cancer. In further embodiments, The invention relates to the pharmaceutical compositions with effective amounts of substituted imidazoline compounds disclosed herein that function as agonist or antagonists of the genetic expression or interactions with transcription factor NF-κB.

摘要翻译： 本发明涉及包含取代的咪唑啉化合物（包括前药）及其盐的组合物。 在一些实施方案中，本发明涉及这些组合物作为治疗剂的用途，优选用于治疗关节炎或癌症。 在进一步的实施方案中，本发明涉及具有有效量的本文公开的取代咪唑啉化合物的药物组合物，其作为基因表达的激动剂或拮抗剂或与转录因子NF-κB的相互作用。