利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

14 条记录 (耗时 0.053 秒)

    Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
    8.
    发明申请
    Reagents for the detection of protein phosphorylation in carcinoma signaling pathways 审中-公开
    用于检测癌症信号通路中蛋白质磷酸化的试剂

    公开(公告)号：US20100151495A9

    公开(公告)日：2010-06-17

    申请号：US12074228

    申请日：2008-02-29

    申请人： Roberto Polakiewicz ,  Ailan Guo ,  Albrecht Moritz ,  Klarisa Rikova ,  Kimberly Lee ,  Erik Spek ,  Yu Li ,  Charles Farnsworth

    发明人： Roberto Polakiewicz ,  Ailan Guo ,  Albrecht Moritz ,  Klarisa Rikova ,  Kimberly Lee ,  Erik Spek ,  Yu Li ,  Charles Farnsworth

    IPC分类号： G01N33/53 ,  C07K16/18 ,  C07K14/00 ,  C12N5/18

    CPC分类号： C07K16/44 ,  G01N33/57426

    摘要： The invention discloses nearly 443 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human carcinoma, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Protein kinases (including Serine/Threonine dual specificity, and Tyrosine kinases), Adaptor/Scaffold proteins, Transcription factors, Phospoatases, Tumor supressors, Ubiquitin conjugating system proteins, Translation initiation complex proteins, RNA binding proteins, Apoptosis proteins, Adhesion proteins, G protein regulators/GTPase activating protein/Guanine nucleotide exchange factor proteins, and DNA binding/replication/repair proteins, as well as other protein types.

    摘要翻译： 本发明公开了在信号转导蛋白中鉴定的近443个新的磷酸化位点和人癌基因的途径，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些磷酸化位点/蛋白质，如 以及使用试剂用于此目的的方法。 鉴定的磷酸化位点是发生在以下蛋白质类型中的位点：蛋白激酶（包括丝氨酸/苏氨酸双特异性和酪氨酸激酶），适配器/支架蛋白，转录因子，磷酸酶，肿瘤抑制因子，泛素缀合系统蛋白，翻译起始复合体 蛋白质，RNA结合蛋白，细胞凋亡蛋白，粘附蛋白，G蛋白调节剂/ GTPase激活蛋白/鸟嘌呤核苷酸交换因子蛋白，以及DNA结合/复制/修复蛋白，以及其他蛋白质类型。

    Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
    9.
    发明申请
    Reagents for the detection of protein phosphorylation in carcinoma signaling pathways 审中-公开
    用于检测癌症信号通路中蛋白质磷酸化的试剂

    公开(公告)号：US20090258442A1

    公开(公告)日：2009-10-15

    申请号：US12074199

    申请日：2008-02-29

    申请人： Roberto Polakiewicz ,  Ailan Guo ,  Albrecht Moritz ,  Klarisa Rikova ,  Kimberly Lee ,  Erik Spek ,  Yu Li ,  Charles Farnsworth

    发明人： Roberto Polakiewicz ,  Ailan Guo ,  Albrecht Moritz ,  Klarisa Rikova ,  Kimberly Lee ,  Erik Spek ,  Yu Li ,  Charles Farnsworth

    IPC分类号： G01N33/536 ,  C07K16/18

    CPC分类号： C07K16/30 ,  C07K16/44 ,  G01N33/57426 ,  G01N33/57496

    摘要： The invention discloses nearly 474 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human carcinoma, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Kinase, Adaptor/Scaffold proteins, Phosphatase, G protein Regulator/Guanine Nucleotide Exchange Factors/GTPase Activating Proteins, Cytoskeleton Proteins, DNA Binding Proteins, Phospholipase, Receptor Proteins, Enzymes, DNA Repair/Replication Proteins, Adhesion Proteins, and Proteases, as well as other protein types.

    摘要翻译： 本发明公开了在信号转导蛋白中鉴定的近474个新的磷酸化位点和人癌基因的途径，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些磷酸化位点/蛋白质，如 以及使用试剂用于此目的的方法。 鉴定的磷酸化位点是发生在以下蛋白质类型中的位点：激酶，适配器/支架蛋白，磷酸酶，G蛋白调节剂/鸟嘌呤核苷酸交换因子/ GTP酶活化蛋白，细胞骨架蛋白，DNA结合蛋白，磷脂酶，受体蛋白，酶， DNA修复/复制蛋白，粘附蛋白和蛋白酶，以及其他蛋白质类型。

    Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
    10.
    发明申请
    Reagents for the detection of protein phosphorylation in carcinoma signaling pathways 审中-公开
    用于检测癌症信号通路中蛋白质磷酸化的试剂

    公开(公告)号：US20090061459A1

    公开(公告)日：2009-03-05

    申请号：US12074228

    申请日：2008-02-29

    申请人： Roberto Polakiewicz ,  Ailan Guo ,  Albrecht Moritz ,  Klarisa Rikova ,  Kimberly Lee ,  Erik Spek ,  Yu Li ,  Charles Farnsworth

    发明人： Roberto Polakiewicz ,  Ailan Guo ,  Albrecht Moritz ,  Klarisa Rikova ,  Kimberly Lee ,  Erik Spek ,  Yu Li ,  Charles Farnsworth

    IPC分类号： G01N33/53 ,  C07K16/18 ,  C07K14/00 ,  C12N5/18

    CPC分类号： C07K16/44 ,  G01N33/57426

    摘要： The invention discloses nearly 443 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human carcinoma, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Protein kinases (including Serine/Threonine dual specificity, and Tyrosine kinases), Adaptor/Scaffold proteins, Transcription factors, Phospoatases, Tumor supressors, Ubiquitin conjugating system proteins, Translation initiation complex proteins, RNA binding proteins, Apoptosis proteins, Adhesion proteins, G protein regulators/GTPase activating protein/Guanine nucleotide exchange factor proteins, and DNA binding/replication/repair proteins, as well as other protein types.

    摘要翻译： 本发明公开了在信号转导蛋白中鉴定的近443个新的磷酸化位点和人癌基因的途径，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些磷酸化位点/蛋白质，如 以及使用试剂用于此目的的方法。 鉴定的磷酸化位点是发生在以下蛋白质类型中的位点：蛋白激酶（包括丝氨酸/苏氨酸双特异性和酪氨酸激酶），适配器/支架蛋白，转录因子，磷酸酶，肿瘤抑制因子，泛素缀合系统蛋白，翻译起始复合体 蛋白质，RNA结合蛋白，细胞凋亡蛋白，粘附蛋白，G蛋白调节剂/ GTPase激活蛋白/鸟嘌呤核苷酸交换因子蛋白，以及DNA结合/复制/修复蛋白，以及其他蛋白质类型。