-
1.发明授权Modifications of 2-amino-4-(4-fluorobenzylamino)-1-ethoxycarbonylaminobenzene, and processes for their preparation 有权2-氨基-4-（4-氟苄基氨基）-1-乙氧基羰基氨基苯的改性及其制备方法公开(公告)号：US06538151B1
公开(公告)日：2003-03-25
申请号：US09181671
申请日：1998-10-29
申请人： Peter Meisel , Karl-Friedrich Landgraf , Jürgen Schäfer , Wilfried Thiel , Matthias Rischer , Alfred Olbrich , Bernhard Kutscher
发明人： Peter Meisel , Karl-Friedrich Landgraf , Jürgen Schäfer , Wilfried Thiel , Matthias Rischer , Alfred Olbrich , Bernhard Kutscher
IPC分类号： C07C26908
CPC分类号： C07C271/28
摘要： The invention relates to novel modifications of the compound 2-amino-4-(4-fluorobenzylamino)-1-ethoxy-carbonylaminobenzene of the processes for their preparation and their use in pharmaceutical compositions.
摘要翻译： 本发明涉及其制备方法的化合物2-氨基-4-（4-氟苄基氨基）-1-乙氧基羰基氨基苯的新颖改性及其在药物组合物中的应用。
-
2.发明授权Modifications of 2-amino-4-(4-5fluorobenzylamino)-1-ethoxycarbonylaminobenzene, and processes for their preparation 失效2-氨基-4-（4-氟苄基氨基）-1-乙氧基羰基氨基苯的改性及其制备方法
公开(公告)号：US5914425A
公开(公告)日：1999-06-22
申请号：US4926
申请日：1998-01-09
申请人： Peter Meisel , Karl-Friedrich Landgraf , Jurgen Schafer , Wilfried Thiel , Matthias Rischer , Alfred Olbrich , Bernhard Kutscher
发明人： Peter Meisel , Karl-Friedrich Landgraf , Jurgen Schafer , Wilfried Thiel , Matthias Rischer , Alfred Olbrich , Bernhard Kutscher
IPC分类号： A61P25/04 , A61K31/27 , A61P25/08 , A61P29/00 , C07C269/08 , C07C271/28 , C07C261/00
CPC分类号： C07C271/28
摘要： The invention relates to novel modifications of the compound 2-amino-4-(4-fluorobenzylamino)-1-ethoxy-carbonylaminobenzene of the formula I ##STR1## processes for their preparation and their use in pharmaceutical compositions.
摘要翻译： 本发明涉及式I化合物2-氨基-4-（4-氟苄基氨基）-1-乙氧羰基氨基苯的新型修饰方法，其制备及其在药物组合物中的应用。
-
公开(公告)号：US5994393A
公开(公告)日：1999-11-30
申请号：US74645
申请日：1998-05-08
申请人： Thomas Beisswenger , Gunter Laban , Karl-Friedrich Landgraf , Eberhard Oestreich , Matthias Rischer
发明人： Thomas Beisswenger , Gunter Laban , Karl-Friedrich Landgraf , Eberhard Oestreich , Matthias Rischer
IPC分类号： A61K31/265 , A61K31/385 , C07D339/04 , A01N43/26
CPC分类号： C07D339/04
摘要： The invention is relative to a thioctic acid with a predominant amount of an enantiomer and a novel modification, in the case of which the X-ray powder diffractograms show a characteristic reflex in the range of 23.4 to 22.7.degree. 2 theta(Cu) which shifts in the direction of the smaller angular values as the enantiomer content increases.
摘要翻译： 本发明相对于具有主要量的对映异构体和新型改性的硫辛酸，在这种情况下，X射线粉末衍射图显示在23.4至22.7°2（Cu）范围内的特性反射，其偏移 在对映异构体含量增加时，角度值越小的方向。
-
公开(公告)号：US20070161571A1
公开(公告)日：2007-07-12
申请号：US11711235
申请日：2007-02-27
申请人： Werner Sarlikiotis , Horst Bauer , Matthias Rischer , Jurgen Engel , Frank Guthlein , Dominique Di Stefano
发明人： Werner Sarlikiotis , Horst Bauer , Matthias Rischer , Jurgen Engel , Frank Guthlein , Dominique Di Stefano
CPC分类号： A61K31/19 , A61K9/0019 , A61K38/09 , A61K47/26
摘要： An aqueous injectable solution of an LHRH antagonist, such as Cetrorelix, in an organic, pharmaceutically acceptable acid, such as gluconic acid.
摘要翻译： LHRH拮抗剂的注射用水溶液，例如Cetrorelix，在有机的药学上可接受的酸如葡萄糖酸中。
-
公开(公告)号：US5990152A
公开(公告)日：1999-11-23
申请号：US800239
申请日：1997-02-12
IPC分类号： A23L1/30 , A23L1/304 , A23L1/305 , A61K9/00 , A61K9/02 , A61K9/12 , A61K9/16 , A61K9/20 , A61K9/22 , A61K9/28 , A61K9/48 , A61K31/385
CPC分类号： A61K9/006 , A61K31/385 , A61K9/0095 , A61K9/02 , A61K9/1658 , A61K9/2018 , A61K9/2054 , A61K9/0075 , A61K9/008 , A61K9/12 , A61K9/1652 , A61K9/2077 , A61K9/2866 , A61K9/4858
摘要： Novel, advantageous dosage forms of thioctic acid and the enantiomers thereof together with thioctic acid salts are described. The pharmaceutical formulations according to the invention are used for the production of pharmaceutical dosage forms which release the active ingredient more rapidly and have greater bioavailability than previous forms.
-
6.发明授权Sterile suspensions of slightly soluble basic peptide complexes and pharmaceutical formulations containing them 失效微溶性碱性肽复合物和含有它们的药物制剂的无菌悬浮液公开(公告)号：US07906479B2
公开(公告)日：2011-03-15
申请号：US12100674
申请日：2008-04-10
申请人： Matthias Rischer , Horst Mueller , Karl Werner , Juergen Engel
发明人： Matthias Rischer , Horst Mueller , Karl Werner , Juergen Engel
CPC分类号： A61K9/19 , A61K9/0019 , A61K9/10 , A61K31/19 , A61K38/09 , A61K47/26 , G06F19/00 , A61K2300/00
摘要： The invention provides sterile suspensions and sterile lyophilizates of slightly soluble basic peptide complexes, and pharmaceutical formulations comprising them. The provided sterile suspensions, sterile lyophilizates and pharmaceutical formulations comprising them are particularly suitable for use in a parenteral dosage form as medicaments for the treatment and prophylaxis of diseases and pathological states in mammals, especially in humans.
摘要翻译： 本发明提供无菌悬浮液和微溶性碱性肽复合物的无菌冻干物和包含它们的药物制剂。 提供的无菌悬浮液，无菌冻干物和包含它们的药物制剂特别适用于肠胃外剂型，作为用于治疗和预防哺乳动物，特别是人的疾病和病理状态的药物。
-
7.发明授权Process for producing sterile suspensions of slightly soluble basic peptide complexes, sterile suspensions of slightly soluble basic peptide complexes, pharmaceutical formulations containing them, and the use thereof as medicaments 失效用于生产微溶碱性肽复合物的无菌悬浮液，微溶性碱性肽复合物的无菌悬浮液，含有它们的药物制剂及其作为药物的用途的方法公开(公告)号：US07871977B2
公开(公告)日：2011-01-18
申请号：US11304548
申请日：2005-12-16
申请人： Matthias Rischer , Horst Mueller , Karl Werner , Juergen Engel
发明人： Matthias Rischer , Horst Mueller , Karl Werner , Juergen Engel
CPC分类号： A61K9/19 , A61K9/0019 , A61K9/10 , A61K31/19 , A61K38/09 , A61K47/26 , G06F19/00 , A61K2300/00
摘要： The present invention provides a novel process for producing sterile suspensions of slightly soluble basic peptide complexes. The present invention further provides a novel process for producing sterile lyophilizates of slightly soluble basic peptide complexes. In addition, a novel process for producing sterile suspensions suitable for the parenteral administration of slightly soluble basic peptide complexes is provided. The invention moreover provides sterile suspensions and sterile lyophilizates of slightly soluble basic peptide complexes, and pharmaceutical formulations comprising them. The provided sterile suspensions, sterile lyophilizates and pharmaceutical formulations comprising them are particularly suitable for use in a parenteral dosage form as medicaments for the treatment and prophylaxis of diseases and pathological states in mammals, especially in humans.
摘要翻译： 本发明提供了一种生产微溶性碱性肽复合物的无菌悬浮液的新方法。 本发明还提供了用于生产微溶性碱性肽复合物的无菌冻干物的新方法。 此外，提供了一种用于生产适于胃肠外施用微溶性碱性肽复合物的无菌悬浮液的新方法。 此外，本发明提供了无菌悬浮液和微溶性碱性肽复合物的无菌冻干物，以及包含它们的药物制剂。 提供的无菌悬浮液，无菌冻干物和包含它们的药物制剂特别适用于肠胃外剂型，作为用于治疗和预防哺乳动物，特别是人的疾病和病理状态的药物。
-
公开(公告)号：US07214662B2
公开(公告)日：2007-05-08
申请号：US10279625
申请日：2002-10-23
申请人： Werner Sarlikiotis , Horst Bauer , Matthias Rischer , Jürgen Engel , Frank Güthlein , Dominique Di Stefano
发明人： Werner Sarlikiotis , Horst Bauer , Matthias Rischer , Jürgen Engel , Frank Güthlein , Dominique Di Stefano
IPC分类号： A61K38/00
CPC分类号： A61K31/19 , A61K9/0019 , A61K38/09 , A61K47/26
摘要： An aqueous injectable soution of an LHRH antagonist, such as Cetrorelix, in an organic, pharmaceutically acceptable acid, such as gluconic acid.
摘要翻译： 在有机的药学上可接受的酸如葡萄糖酸中的LHRH拮抗剂如Cetrorelix的注射用水溶液。
-
9.发明申请Process for producing sterile suspensions of slightly soluble basic peptide complexes, sterile suspensions of slightly soluble basic peptide complexes, pharmaceutical formulations containing them, and the use thereof as medicaments 失效用于生产微溶碱性肽复合物的无菌悬浮液，微溶性碱性肽复合物的无菌悬浮液，含有它们的药物制剂及其作为药物的用途的方法公开(公告)号：US20060135405A1
公开(公告)日：2006-06-22
申请号：US11304548
申请日：2005-12-16
申请人： Matthias Rischer , Horst Mueller , Karl Werner , Juergen Engel
发明人： Matthias Rischer , Horst Mueller , Karl Werner , Juergen Engel
IPC分类号： A61K38/16
CPC分类号： A61K9/19 , A61K9/0019 , A61K9/10 , A61K31/19 , A61K38/09 , A61K47/26 , G06F19/00 , A61K2300/00
摘要： The present invention provides a novel process for producing sterile suspensions of slightly soluble basic peptide complexes. The present invention further provides a novel process for producing sterile lyophilizates of slightly soluble basic peptide complexes. In addition, a novel process for producing sterile suspensions suitable for the parenteral administration of slightly soluble basic peptide complexes is provided. The invention moreover provides sterile suspensions and sterile lyophilizates of slightly soluble basic peptide complexes, and pharmaceutical formulations comprising them. The provided sterile suspensions, sterile lyophilizates and pharmaceutical formulations comprising them are particularly suitable for use in a parenteral dosage form as medicaments for the treatment and prophylaxis of diseases and pathological states in mammals, especially in humans.
摘要翻译： 本发明提供了一种生产微溶性碱性肽复合物的无菌悬浮液的新方法。 本发明还提供了用于生产微溶性碱性肽复合物的无菌冻干物的新方法。 此外，提供了一种用于生产适于胃肠外施用微溶性碱性肽复合物的无菌悬浮液的新方法。 此外，本发明提供了无菌悬浮液和微溶性碱性肽复合物的无菌冻干物，以及包含它们的药物制剂。 提供的无菌悬浮液，无菌冻干物和包含它们的药物制剂特别适用于肠胃外剂型，作为用于治疗和预防哺乳动物，特别是人的疾病和病理状态的药物。
-
公开(公告)号：US07790686B2
公开(公告)日：2010-09-07
申请号：US11711235
申请日：2007-02-27
申请人： Werner Sarlikiotis , Horst Bauer , Matthias Rischer , Jürgen Engel , Frank Güthlein , Dominique Di Stefano
发明人： Werner Sarlikiotis , Horst Bauer , Matthias Rischer , Jürgen Engel , Frank Güthlein , Dominique Di Stefano
IPC分类号： A61K38/00
CPC分类号： A61K31/19 , A61K9/0019 , A61K38/09 , A61K47/26
摘要： An aqueous injectable solution of an LHRH antagonist, such as Cetrorelix, in an organic, pharmaceutically acceptable acid, such as gluconic acid.
摘要翻译： LHRH拮抗剂的注射用水溶液，例如Cetrorelix，在有机的药学上可接受的酸如葡萄糖酸中。
-
-
-
-
-
-
-
-
-
搜索结果
12 条记录 (耗时 0.03 秒)
