公开(公告)号：US5122462A

公开(公告)日：1992-06-16

申请号：US670437

申请日：1991-03-18

申请人： Peter Miethe ,  Maria-Regina Kula ,  Ingeborg M. Stuertz ,  Christian Wandrey ,  Udo Kragl

发明人： Peter Miethe ,  Maria-Regina Kula ,  Ingeborg M. Stuertz ,  Christian Wandrey ,  Udo Kragl

IPC分类号： C12M1/00 ,  C12M1/40 ,  C12P13/00 ,  C12P41/00

CPC分类号： C12P13/004 ,  C12M21/18 ,  C09K2219/15

摘要： The preparation of optically-active cyanohydrins from the corresponding oxo compounds is disclosed. The reaction of the oxo compounds with hydrocyanic acid is carried out in an organic solvent in the presence of (R)- or (S)-oxynitrilase (4.1.2.10) and (4.1.2.11), respectively, being solubilized in a lyotropic liquid crystal. Compounds which upon hydrolysis produce increased pH values are excluded as surface active agents. Preferably, surface active agents, the organic solvent and an aqueous buffer solution with a pH of 3 to 6, are mixed together to obtain a liquid crystal/organic solvent two-phase system. The liquid crystal is preferably fixed on a porous support, in particular a glass support. The reaction is carried out in a flow-through reactor which contains the liquid crystal in the abovementioned form or in thin layers adjacent to narrow flow channels, the borders of which are liquid permeable and through which the substrate-containing solvent is passed.

摘要翻译： 公开了从相应的氧代化合物制备光学活性的氰醇。 氧代化合物与氢氰酸的反应在有机溶剂中分别在（R） - 或（S） - 硝基腈酶（4.1.2.10）和（4.1.2.11）的存在下进行，溶解在溶致液体 水晶。 在水解产生增加的pH值的化合物被排除作为表面活性剂。 优选将表面活性剂，有机溶剂和pH为3〜6的缓冲水溶液混合在一起，得到液晶/有机溶剂两相体系。 液晶优选固定在多孔载体上，特别是玻璃载体上。 该反应在含有上述形式的液晶的流通反应器中或邻近窄流道的薄层中进行，该流动通道的边界是液体可渗透的并且含底物的溶剂通过该反应器。