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公开(公告)号：US09353172B2
公开(公告)日：2016-05-31
申请号：US14233455
申请日：2012-07-09
CPC分类号： A61K47/48284 , A61K38/24 , A61K47/60 , A61K47/643 , A61K47/644 , A61K47/68 , C07K14/59 , C07K14/76 , C07K2319/31
摘要： The present invention relates to a long acting biologically active luteinizing hormone (LH) compound comprising an LH agonist linked to a pharmaceutically acceptable molecule providing an in vivo plasma half-life of the LH agonist or LH compound which is increased substantially compared to the in vivo plasma half-life of an LH agonist administered in the same manner as the LH compound. The present invention relates to methods for controlled ovarian stimulation which can be used in conjunction with assisted reproduction technologies such as in vitro fertilization, intra cytoplasmatic sperm injection, intra uterine insemination and in vitro maturation. In other aspects the invention relates to methods for inducing folliculogenesis and methods for providing luteal support for the corpora lutea.
摘要翻译： 本发明涉及一种长效生物活性黄体生成激素（LH）化合物，其包含与药学上可接受的分子连接的LH激动剂，所述LH激动剂提供LH激动剂或LH化合物的体内血浆半衰期，其与体内相比大大增加 以与LH化合物相同的方式施用LH激动剂的血浆半衰期。 本发明涉及用于受控卵巢刺激的方法，其可以与辅助生殖技术如体外受精，细胞内精子注射，子宫内子宫内受精和体外成熟结合使用。 在其他方面，本发明涉及诱导卵泡发生的方法以及为黄体提供黄体支持的方法。
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公开(公告)号：US20140228292A1
公开(公告)日：2014-08-14
申请号：US14233455
申请日：2012-07-09
CPC分类号： A61K47/48284 , A61K38/24 , A61K47/60 , A61K47/643 , A61K47/644 , A61K47/68 , C07K14/59 , C07K14/76 , C07K2319/31
摘要： The present invention relates to a long acting biologically active luteinizing hormone (LH) compound comprising an LH agonist linked to a pharmaceutically acceptable molecule providing an in vivo plasma half-life of the LH agonist or LH compound which is increased substantially compared to the in vivo plasma half-life of an LH agonist administered in the same manner as the LH compound. The present invention relates to methods for controlled ovarian stimulation which can be used in conjunction with assisted reproduction technologies such as in vitro fertilisation, intra cytoplasmatic sperm injection, intra uterine insemination and in vitro maturation. In other aspects the invention relates to methods for inducing folliculogenesis and methods for providing luteal support for the corpora lutea.
摘要翻译： 本发明涉及一种长效生物活性黄体生成激素（LH）化合物，其包含与药学上可接受的分子连接的LH激动剂，所述LH激动剂提供LH激动剂或LH化合物的体内血浆半衰期，其与体内相比大大增加 以与LH化合物相同的方式施用LH激动剂的血浆半衰期。 本发明涉及用于受控卵巢刺激的方法，其可以与辅助生殖技术如体外受精，细胞内精子注射，子宫内子宫内受精和体外成熟结合使用。 在其他方面，本发明涉及诱导卵泡发生的方法以及为黄体提供黄体支持的方法。
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公开(公告)号：US20090281370A1
公开(公告)日：2009-11-12
申请号：US12482031
申请日：2009-06-10
申请人： Svend Lindenberg
发明人： Svend Lindenberg
IPC分类号： A61B17/43
CPC分类号： C12N5/061 , C12M21/06 , C12M23/34 , C12M41/34 , C12N5/0604 , C12N5/0609 , C12N15/873 , C12N2500/02 , C12N2501/392 , C12N2501/48 , C12N2501/999 , C12N2517/10
摘要： The present invention relates to a method and a system for producing a mammalian pre-embryo and a stem cell having a better quality than prior art methods. The system comprises means for obtaining a mammalian oocyte, and means for obtaining a mammalian spermatozoa, and an apparatus having at least two separate air-tight chambers, for which the oxygen tension of one chamber may be changed independent of the oxygen tension of the other chamber, said at least two separate air-tight chambers constitute a main chamber and at least one residence chamber. The method for in vitro producing a mammalian pre-embryo comprising the steps: a1) providing a mammalian oocyte, a2) providing a mammalian spermatozoa, b) culturing the oocyte and the spermatozoa, c) fertilizing the oocyte with the spermatozoa obtaining a fertilized oocyte, and d) allowing cell-division of the fertilized oocyte obtaining a multicellular pre-embryo wherein at least one of the steps a1) or a2) is conducted at an oxygen tension below 15%, or e) allowing cell-division of the fertilized oocyte obtaining a multicellular pre-embryo, wherein the culture is performed at an oxygen tension allowing cultivation of the cells and wherein at least one of the steps comprises a change in the oxygen tension Stem cells are produced from the multicellular pre-embryo.
摘要翻译： 本发明涉及用于生产具有比现有技术方法更好的质量的哺乳动物前胚胎和干细胞的方法和系统。 该系统包括用于获得哺乳动物卵母细胞的装置和用于获得哺乳动物精子的装置，以及具有至少两个单独的气密室的装置，一个室的氧气张力可以独立于另一个室的氧气张力而改变 所述至少两个单独的气密室构成主室和至少一个室。 用于体外产生哺乳动物前胚胎的方法包括以下步骤：a1）提供哺乳动物卵母细胞，a2）提供哺乳动物精子，b）培养卵母细胞和精子，c）用精子施肥卵母细胞获得受精卵母细胞 和d）允许受精卵母细胞的细胞分裂获得多细胞前胚胎，其中至少一个步骤a1）或a2）在低于15％的氧气压力下进行，或e）允许受精的卵母细胞的细胞分裂 卵母细胞获得多细胞前胚胎，其中所述培养在氧气压力下进行，允许细胞培养，并且其中至少一个步骤包括氧气张力的变化从多细胞胚胎前体产生干细胞。
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公开(公告)号：US09078914B2
公开(公告)日：2015-07-14
申请号：US13394649
申请日：2010-09-10
申请人： Flemming Velin , Svend Lindenberg
发明人： Flemming Velin , Svend Lindenberg
IPC分类号： C07H21/02 , C07H21/04 , A61K31/713 , A61K9/00 , A61K9/50 , C12N15/113
CPC分类号： A61K31/713 , A61K9/0019 , A61K9/5094 , C12N15/113 , C12N2310/141 , C12N2330/10
摘要： The present invention relates to compositions comprising a therapeutically effective amount of miRNAs, their use for the treatment of medical conditions benefiting from being treated with these compositions, as well as methods for the preparation of compositions comprising miRNAs.
摘要翻译： 本发明涉及包含治疗有效量的miRNA的组合物，其用于治疗有益于用这些组合物治疗的医学病症的用途，以及制备包含miRNA的组合物的方法。
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5.发明申请METHOD AND DEVICE FOR TREATMENT OF CONDITIONS ASSOCIATED WITH INFLAMMATION OR UNDESIRABLE ACTIVATION OF THE IMMUNE SYSTEM 审中-公开用于治疗与免疫系统的炎症反应或不能激活相关的病症的方法和装置公开(公告)号：US20120093936A1
公开(公告)日：2012-04-19
申请号：US13262677
申请日：2010-04-07
申请人： Svend Lindenberg , Flemming Velin
发明人： Svend Lindenberg , Flemming Velin
IPC分类号： A61K35/16 , A61K9/00 , A61K39/395 , A61P1/02 , A61P1/04 , A61P29/00 , A61P25/00 , A61P15/00 , A61P25/16 , A61P25/28 , A61P3/10 , A61P19/10 , A61P17/06 , A61P35/00 , A61P17/02 , C12M3/00 , A61K9/14
CPC分类号： A61K35/16
摘要： The present invention relates to methods and compositions for use in the treatment of specific medical conditions. The compositions of the invention comprise blood serum preparations, such as activated blood serum preparations. The present invention also relates to the use of such blood serum preparations for the treatment of diseases and disorders associated with inflammation and/or undesirable activation of the immune system, such as paradentosis, abortus habitualis, colitis ulcerosa, polymyalgia rheumatica, whiplash-associated disorders, endometriosis, adeomyosis and unexplained infertility.
摘要翻译： 本发明涉及用于治疗特定医学病症的方法和组合物。 本发明的组合物包括血清制剂，例如活化血清制剂。 本发明还涉及这样的血清制剂用于治疗与免疫系统的炎症和/或不期望的激活相关的疾病和病症的用途，所述疾病和病症例如是异位症，流产性习惯性结肠炎，溃疡性结肠炎，风湿性多肌痛，鞭打相关疾病 ，子宫内膜异位症，子宫内膜异位症和不明原因不孕。
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公开(公告)号：US07547541B2
公开(公告)日：2009-06-16
申请号：US10518055
申请日：2003-06-17
申请人： Svend Lindenberg
发明人： Svend Lindenberg
CPC分类号： C12N5/061 , C12M21/06 , C12M23/34 , C12M41/34 , C12N5/0604 , C12N5/0609 , C12N15/873 , C12N2500/02 , C12N2501/392 , C12N2501/48 , C12N2501/999 , C12N2517/10
摘要： The present invention relates to a method and a system for producing a mammalian pre-embryo and a stem cell having a better quality than prior art methods. The system comprises means for obtaining a mammalian oocyte, and means for obtaining a mammalian spermatozoa, and an apparatus having at least two separate air-tight chambers, for which the oxygen tension of one chamber may be changed independent of the oxygen tension of the other chamber, said at least two separate air-tight chambers constitute a main chamber and at least one residence chamber. The method for in vitro producing a mammalian pre-embryo comprising the steps: a1) providing a mammalian oocyte, a2) providing a mammalian spermatozoa, b) culturing the oocyte and the spermatozoa, c) fertilizing the oocyte with the spermatozoa obtaining a fertilized oocyte, and d) allowing cell-division of the fertilized oocyte obtaining a multicellular pre-embryo wherein at least one of the steps a1) or a2) is conducted at an oxygen tension below 15%, or e) allowing cell-division of the fertilized oocyte obtaining a multicellular pre-embryo, wherein the culture is performed at an oxygen tension allowing cultivation of the cells and wherein at least one of the steps comprises a change in the oxygen tension. Stem cells are produced from the multicellular pre-embryo.
摘要翻译： 本发明涉及用于生产具有比现有技术方法更好的质量的哺乳动物前胚胎和干细胞的方法和系统。 该系统包括用于获得哺乳动物卵母细胞的装置和用于获得哺乳动物精子的装置，以及具有至少两个单独的气密室的装置，一个室的氧气张力可以独立于另一个室的氧气张力而改变 所述至少两个单独的气密室构成主室和至少一个室。 用于体外产生哺乳动物前胚胎的方法包括以下步骤：a1）提供哺乳动物卵母细胞，a2）提供哺乳动物精子，b）培养卵母细胞和精子，c）用精子施肥卵母细胞获得受精卵母细胞 和d）允许受精卵母细胞的细胞分裂获得多细胞前胚胎，其中至少一个步骤a1）或a2）在低于15％的氧气压力下进行，或e）允许受精的卵母细胞的细胞分裂 卵母细胞获得多细胞前胚胎，其中所述培养在氧气压力下进行，允许细胞培养，并且其中至少一个步骤包括氧张力的变化。 干细胞是从多细胞前胚胎产生的。
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7.发明申请公开(公告)号：US20120172416A1
公开(公告)日：2012-07-05
申请号：US13394649
申请日：2010-09-10
申请人： Flemming Velin , Svend Lindenberg
发明人： Flemming Velin , Svend Lindenberg
CPC分类号： A61K31/713 , A61K9/0019 , A61K9/5094 , C12N15/113 , C12N2310/141 , C12N2330/10
摘要： The present invention relates to compositions comprising a therapeutically effective amount of miRNAs, their use for the treatment of medical conditions benefiting from being treated with these compositions, as well as methods for the preparation of compositions comprising miRNAs.
摘要翻译： 本发明涉及包含治疗有效量的miRNA的组合物，其用于治疗有益于用这些组合物治疗的医学病症的用途，以及用于制备包含miRNA的组合物的方法。
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公开(公告)号：US07781207B2
公开(公告)日：2010-08-24
申请号：US12482031
申请日：2009-06-10
申请人： Svend Lindenberg
发明人： Svend Lindenberg
CPC分类号： C12N5/061 , C12M21/06 , C12M23/34 , C12M41/34 , C12N5/0604 , C12N5/0609 , C12N15/873 , C12N2500/02 , C12N2501/392 , C12N2501/48 , C12N2501/999 , C12N2517/10
摘要： The present invention relates to a method and a system for producing a mammalian pre-embryo and a stem cell having a better quality than prior art methods. The system comprises means for obtaining a mammalian oocyte, and means for obtaining a mammalian spermatozoa, and an apparatus having at least two separate air-tight chambers, for which the oxygen tension of one chamber may be changed independent of the oxygen tension of the other chamber, said at least two separate air-tight chambers constitute a main chamber and at least one residence chamber. The method for in vitro producing a mammalian pre-embryo comprising the steps: a1) providing a mammalian oocyte, a2) providing a mammalian spermatozoa, b) culturing the oocyte and the spermatozoa, c) fertilizing the oocyte with the spermatozoa obtaining a fertilized oocyte, and d) allowing cell-division of the fertilized oocyte obtaining a multicellular pre-embryo wherein at least one of the steps a1) or a2) is conducted at an oxygen tension below 15%, or e) allowing cell-division of the fertilized oocyte obtaining a multicellular pre-embryo, wherein the culture is performed at an oxygen tension allowing cultivation of the cells and wherein at least one of the steps comprises a change in the oxygen tension Stem cells are produced from the multicellular pre-embryo.
摘要翻译： 本发明涉及用于生产具有比现有技术方法更好的质量的哺乳动物前胚胎和干细胞的方法和系统。 该系统包括用于获得哺乳动物卵母细胞的装置和用于获得哺乳动物精子的装置，以及具有至少两个单独的气密室的装置，一个室的氧气张力可以独立于另一个室的氧气张力而改变 所述至少两个单独的气密室构成主室和至少一个室。 用于体外产生哺乳动物前胚胎的方法包括以下步骤：a1）提供哺乳动物卵母细胞，a2）提供哺乳动物精子，b）培养卵母细胞和精子，c）用精子施肥卵母细胞获得受精卵母细胞 和d）允许受精卵母细胞的细胞分裂获得多细胞前胚胎，其中至少一个步骤a1）或a2）在低于15％的氧气压力下进行，或e）允许受精的卵母细胞的细胞分裂 卵母细胞获得多细胞前胚胎，其中所述培养在氧气压力下进行，允许细胞培养，并且其中至少一个步骤包括氧气张力的变化从多细胞胚胎前体产生干细胞。
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公开(公告)号：US20050239040A1
公开(公告)日：2005-10-27
申请号：US10518055
申请日：2003-06-17
申请人： Svend Lindenberg
发明人： Svend Lindenberg
IPC分类号： C12M1/00 , A01N1/02 , A61K35/12 , A61P15/00 , C12M1/24 , C12M1/26 , C12M1/36 , C12M1/38 , C12M3/00 , C12N5/075 , C12N5/076 , C12N15/85 , C12N15/873
CPC分类号： C12N5/061 , C12M21/06 , C12M23/34 , C12M41/34 , C12N5/0604 , C12N5/0609 , C12N15/873 , C12N2500/02 , C12N2501/392 , C12N2501/48 , C12N2501/999 , C12N2517/10
摘要： The present invention relates to a method and a system for producing a mammalian pre-embryo and a stem cell having a better quality than prior art methods. The system comprises means for obtaining a mammalian oocyte, and means for obtaining a mammalian spermatozoa, and an apparatus having at least two separate air-tight chambers, for which the oxygen tension of one chamber may be changed independent of the oxygen tension of the other chamber, said at least two separate air-tight chambers constitute a main chamber and at least one residence chamber. The method for in vitro producing a mammalian pre-embryo comprising the steps: a1) providing a mammalian oocyte, a2) providing a mammalian spermatozoa, b) culturing the oocyte and the spermatozoa, c) fertilizing the oocyte with the spermatozoa obtaining a fertilized oocyte, and d) allowing cell-division of the fertilized oocyte obtaining a multicellular pre-embryo wherein at least one of the steps a1) or a2) is conducted at an oxygen tension below 15%, or e) allowing cell-division of the fertilized oocyte obtaining a multicellular pre-embryo, wherein the culture is performed at an oxygen tension allowing cultivation of the cells and wherein at least one of the steps comprises a change in the oxygen tension. Stem cells are produced from the multicellular pre-embryo.
摘要翻译： 本发明涉及用于生产具有比现有技术方法更好的质量的哺乳动物前胚胎和干细胞的方法和系统。 该系统包括用于获得哺乳动物卵母细胞的装置和用于获得哺乳动物精子的装置，以及具有至少两个单独的气密室的装置，一个室的氧气张力可以独立于另一个室的氧气张力而改变 所述至少两个单独的气密室构成主室和至少一个室。 用于体外产生哺乳动物前胚胎的方法包括以下步骤：a1）提供哺乳动物卵母细胞，a2）提供哺乳动物精子，b）培养卵母细胞和精子，c）用精子施肥卵母细胞获得受精卵母细胞 和d）允许受精卵母细胞的细胞分裂获得多细胞前胚胎，其中至少一个步骤a1）或a2）在低于15％的氧气压力下进行，或e）允许受精的卵母细胞的细胞分裂 卵母细胞获得多细胞前胚胎，其中所述培养在氧气压力下进行，允许细胞培养，并且其中至少一个步骤包括氧张力的变化。 干细胞是从多细胞前胚胎产生的。
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公开(公告)号：US06649344B1
公开(公告)日：2003-11-18
申请号：US09720472
申请日：2001-03-13
IPC分类号： G01N33533
CPC分类号： G01N33/689 , A61K38/00 , C12N5/0609 , C12N2500/90 , C12N2501/48 , C12N2501/999 , C12N2517/10 , G01N33/743 , G01N2333/726 , G01N2800/368 , Y10S436/806 , Y10S436/811
摘要： The present invention relates to an assay for at least one predictive marker in a sample from a mammal wherein a specific reaction for at least one predictive marker indicates when non-fertilizable ova capable of in vitro maturation (IVM) and subsequent in vitro fertilization (IVF) are present in the mammal. This is particularly useful in the determination of when non-fertilizable ova, if aspirated, after in vitro maturation to MF-II will be capable of fertilization and pregnancy after implantation into the female mammal. The assay is based on a sample selected from the group consisting of body secrete, sputum, blood, urine, uterus secretes and cells.
摘要翻译： 本发明涉及来自哺乳动物样品中至少一种预测标记的测定法，其中至少一种预测标记的特异性反应指示何时能够体外成熟（IVM）和随后的体外受精（IVF）的非肥沃的卵 ）存在于哺乳动物中。 这在确定何时不能施肥的卵，如果吸入，在MF-II的体外成熟后将能够在植入雌性哺乳动物后受精和怀孕。 该测定法基于选自身体分泌物，痰液，血液，尿液，子宫分泌物和细胞的样品。
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