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45 条记录 (耗时 0.038 秒)

    Heterocyclic amides
    4.
    发明授权
    Heterocyclic amides 失效
    杂环酰胺

    公开(公告)号：US5521179A

    公开(公告)日：1996-05-28

    申请号：US045009

    申请日：1993-04-08

    申请人： Peter R. Bernstein ,  Andrew Shaw ,  Royston M. Thomas ,  Peter Warner ,  Donald J. Wolanin

    发明人： Peter R. Bernstein ,  Andrew Shaw ,  Royston M. Thomas ,  Peter Warner ,  Donald J. Wolanin

    IPC分类号： A61K38/00 ,  C07K5/06 ,  C07D237/00 ,  C07D211/72 ,  C07D215/14 ,  C07D401/00

    CPC分类号： C07K5/06191 ,  A61K38/00

    摘要： The present invention relates to certain novel heterocyclic amides which are 1-pyridylacetamide compounds of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic amides, processes for preparing the heterocyclic amides, pharmaceutical compositions containing such heterocyclic amides and methods for their use.

    摘要翻译： 本发明涉及某些新颖的杂环酰胺，它们是本文列出的式I的1-吡啶基乙酰胺化合物，其是人类白细胞弹性蛋白酶（HLE）的抑制剂，也被称为人嗜中性粒细胞弹性蛋白酶（HNE）），使得它们在这种抑制 是期望的，例如在药理学，诊断和相关研究中的研究工具以及涉及HLE的哺乳动物的疾病的治疗。 本发明还包括可用于合成这些杂环酰胺的中间体，制备杂环酰胺的方法，含有这种杂环酰胺的药物组合物及其使用方法。

    Amide derivatives
    5.
    发明授权
    Amide derivatives 失效
    酰胺衍生物

    公开(公告)号：US5405852A

    公开(公告)日：1995-04-11

    申请号：US71624

    申请日：1993-06-03

    申请人： Chris A. Veale ,  Peter Warner ,  Donald J. Wolanin

    发明人： Chris A. Veale ,  Peter Warner ,  Donald J. Wolanin

    IPC分类号： A61K38/55 ,  A61K38/00 ,  A61P29/00 ,  C07K1/113 ,  C07K5/06 ,  C07K5/078 ,  A61K31/44 ,  C07D471/06

    CPC分类号： C07K5/06139 ,  A61K38/00

    摘要： The present invention relates to certain novel amide ##STR1## derivatives which are pyrido[3,4-b]indol-2-ylacetamides which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these amide derivatives, processes for preparing the amide derivatives, pharmaceutical compositions containing such amide derivatives and methods for their use.

    摘要翻译： 本发明涉及作为人白细胞弹性蛋白酶（HLE）抑制剂（也称为人嗜中性粒细胞弹性蛋白酶（HNE））的吡啶并[3,4-b]吲哚-2-基乙酰胺的某些新颖的酰胺I型衍生物 如果需要这种抑制，它们是有用的，例如在药理学，诊断和相关研究中的研究工具以及涉及HLE的哺乳动物的疾病的治疗。 本发明还包括可用于合成这些酰胺衍生物的中间体，制备酰胺衍生物的方法，含有这种酰胺衍生物的药物组合物及其使用方法。

    Heterocyclic amides
    6.
    发明授权
    Heterocyclic amides 失效
    杂环酰胺

    公开(公告)号：US5532366A

    公开(公告)日：1996-07-02

    申请号：US375201

    申请日：1995-01-19

    申请人： Philip D. Edwards ,  Peter Warner ,  Donald J. Wolanin

    发明人： Philip D. Edwards ,  Peter Warner ,  Donald J. Wolanin

    IPC分类号： A61K38/00 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P29/00 ,  A61P43/00 ,  C07K1/113 ,  C07K5/06 ,  C07K5/078 ,  C07K14/81 ,  A61K31/505 ,  C07D471/04

    CPC分类号： C07K5/06191 ,  A61K38/00

    摘要： The present invention relates to certain novel amide derivatives which are pyrido[3,4-d]pyrimidin-7-ylacetamides which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these amide derivatives, processes for preparing the amide derivatives, pharmaceutical compositions containing such amide derivatives and methods for their use.

    摘要翻译： 本发明涉及作为人类白细胞弹性蛋白酶（HLE）抑制剂（也称为人嗜中性粒细胞弹性蛋白酶（HNE））的吡啶并[3,4-d]嘧啶-7-基乙酰胺的某些新型酰胺衍生物， 需要抑制，例如在药理学，诊断和相关研究中的研究工具以及涉及HLE的哺乳动物的疾病的治疗。 本发明还包括可用于合成这些酰胺衍生物的中间体，制备酰胺衍生物的方法，含有这种酰胺衍生物的药物组合物及其使用方法。

    Editing media using composite bumps
    9.
    发明授权
    Editing media using composite bumps 有权

    公开(公告)号：US09781309B2

    公开(公告)日：2017-10-03

    申请号：US13471474

    申请日：2012-05-15

    申请人： Andrew Bryant ,  Peter Warner ,  Daniel Pettigrew

    发明人： Andrew Bryant ,  Peter Warner ,  Daniel Pettigrew

    IPC分类号： G09G5/02 ,  H04N1/62 ,  H04N1/407 ,  H04N9/64 ,  H04N9/67 ,  G06T11/00

    CPC分类号： H04N1/622 ,  G06T11/001 ,  H04N1/407 ,  H04N9/643 ,  H04N9/67

    摘要： A non-transitory machine readable medium that has a computer program for adjusting color values of an image represented in a color space is described. The image includes a set of pixels. Each pixel includes a set of color values. The computer program displays a composite bump on a tonal adjustment graph that is defined along a particular color component of the color space. The composite bump is generated by blending several bumps on the tonal adjustment graph. In response to receiving an input on a location on the tonal adjustment graph, the computer program creates a new bump based on the input and blending the new bump with the composite bump to create a modified composite bump. The computer program adjusts the color values of the image based on the modified composite bump.

    MEDIA EDITING WITH OVERLAID COLOR ADJUSTMENT TOOLS
    10.
    发明申请
    MEDIA EDITING WITH OVERLAID COLOR ADJUSTMENT TOOLS 有权
    媒体编辑与OVERLAID颜色调整工具

    公开(公告)号：US20130201202A1

    公开(公告)日：2013-08-08

    申请号：US13471473

    申请日：2012-05-15

    申请人： Andrew Bryant ,  Peter Warner ,  Daniel Pettigrew

    发明人： Andrew Bryant ,  Peter Warner ,  Daniel Pettigrew

    IPC分类号： G09G5/02

    CPC分类号： H04N1/622 ,  G06T11/001 ,  H04N1/407 ,  H04N9/643 ,  H04N9/67

    摘要： A non-transitory machine readable medium that has a computer program for adjusting color values of an image represented in a color space is described. The computer program displays the image on a display device. The computer program receives several inputs on the displayed image. The several inputs include a selection of a point on the displayed image and a vector input. The computer program identifies a pixel of the image that corresponds to the selected point. Based on the color values of the identified pixel and the vector input, the program determines a color space transform for mapping a set of color values defined within the color space to a different set of color values.

    摘要翻译： 描述了具有用于调整在颜色空间中表示的图像的颜色值的计算机程序的非暂时机器可读介质。 计算机程序在显示设备上显示图像。 计算机程序在显示的图像上接收多个输入。 多个输入包括对所显示图像上的点的选择和向量输入。 计算机程序识别对应于所选点的图像的像素。 基于识别的像素和向量输入的颜色值，程序确定用于将在颜色空间内定义的一组颜色值映射到不同颜色值集合的颜色空间变换。