公开(公告)号：US07764822B2

公开(公告)日：2010-07-27

申请号：US12253275

申请日：2008-10-17

申请人： Peter Ramm ,  Yuriy Alexandrov ,  Jurich Cybuch ,  Paul Donders ,  Carlos Zarate ,  Bohdan Soltys

发明人： Peter Ramm ,  Yuriy Alexandrov ,  Jurich Cybuch ,  Paul Donders ,  Carlos Zarate ,  Bohdan Soltys

IPC分类号： G06K9/00

CPC分类号： G01N21/6458 ,  G01N15/1475 ,  G01N21/6428 ,  G01N33/5026 ,  G01N2015/1497 ,  G01N2333/4603 ,  G06K9/00127 ,  G06T7/0012 ,  G06T7/187 ,  G06T2207/10056 ,  G06T2207/30024

摘要： A system for performing automated cell screening in drug discovery, includes an automated microscope, a fast autofocus device, and a digital imaging system. Processes are implemented in software through which relevant cellular material is segmented and quantified with minimal user interaction. Improvements in the following areas: known methods for image processing are implemented in such a way that automated segmentation is achieved; sets of known measurements (pixel counting, etc.) are implemented as methods which demonstrate aspects of biology in a reliable fashion; components for automated positioning, focusing, imaging and processing of a multiplicity of samples are integrated as systems within which the segmentation and measurement methods may be mounted; and components and methods are adapted into systems which yield more highly automated and more rapid cell screening.

摘要翻译： 用于在药物发现中进行自动细胞筛选的系统包括自动显微镜，快速自动对焦装置和数字成像系统。 过程在软件中实现，通过该软件，相关的细胞材料通过最小的用户交互被分段和量化。 以下领域的改进：图像处理的已知方法以实现自动分割的方式实现; 已知测量的集合（像素计数等）被实现为以可靠的方式示出生物学方面的方法; 将多个样本的自动定位，聚焦，成像和处理的组件集成为其中可以安装分割和测量方法的系统; 并且组件和方法被适应成产生更高度自动化和更快速的细胞筛选的系统。

公开(公告)号：US20060257013A1

公开(公告)日：2006-11-16

申请号：US10514925

申请日：2003-05-09

申请人： Peter Ramm ,  Yuriy Alexandrov ,  Jurich Cybuch ,  Paul Donders ,  Carlos Zarate ,  Bohdan Soltys

发明人： Peter Ramm ,  Yuriy Alexandrov ,  Jurich Cybuch ,  Paul Donders ,  Carlos Zarate ,  Bohdan Soltys

IPC分类号： G06K9/00

CPC分类号： G01N21/6458 ,  G01N15/1475 ,  G01N21/6428 ,  G01N33/5026 ,  G01N2015/1497 ,  G01N2333/4603 ,  G06K9/00127 ,  G06T7/0012 ,  G06T7/187 ,  G06T2207/10056 ,  G06T2207/30024

摘要： A system for performing automated cell screening in drug discovery, including an automated microscope, a fast autofocus device and a digital imaging system. Processes are implemented in software through which relevant cellular material is segmented and quantified with minimal user interaction. Improvements in the following areas: known methods for image processing are implemented in such a way that automated segmentation is achieved; sets of known measurements (pixel counting, etc.) are implemented as methods which demonstrate aspects of biology in a reliable fashion; components for automated positioning, focusing, imaging and processing of a multiplicity of samples are integrated as systems within which the segmentation and measurement methods may be mounted; and components and methods are adapted into systems which yield more highly automated and more rapid cell screening.

摘要翻译： 一种用于在药物发现中进行自动细胞筛选的系统，包括自动显微镜，快速自动对焦装置和数字成像系统。 过程在软件中实现，通过该软件，相关的细胞材料通过最小的用户交互被分段和量化。 以下领域的改进：图像处理的已知方法以实现自动分割的方式实现; 已知测量的集合（像素计数等）被实现为以可靠的方式示出生物学方面的方法; 将多个样本的自动定位，聚焦，成像和处理的组件集成为其中可以安装分割和测量方法的系统; 并且组件和方法被适应成产生更高度自动化和更快速的细胞筛选的系统。

公开(公告)号：US07469056B2

公开(公告)日：2008-12-23

申请号：US10514925

申请日：2003-05-09

申请人： Peter Ramm ,  Yuriy Alexandrov ,  Jurich Cybuch ,  Paul Donders ,  Carlos Zarate ,  Bohdan J. Soltys

发明人： Peter Ramm ,  Yuriy Alexandrov ,  Jurich Cybuch ,  Paul Donders ,  Carlos Zarate ,  Bohdan J. Soltys

IPC分类号： G06K9/00

CPC分类号： G01N21/6458 ,  G01N15/1475 ,  G01N21/6428 ,  G01N33/5026 ,  G01N2015/1497 ,  G01N2333/4603 ,  G06K9/00127 ,  G06T7/0012 ,  G06T7/187 ,  G06T2207/10056 ,  G06T2207/30024

摘要： A system for performing automated cell screening in drug discovery, including an automated microscope, a fast autofocus device and a digital imaging system. Processes are implemented in software through which relevant cellular material is segmented and quantified with minimal user interaction. Improvements in the following areas: known methods for image processing are implemented in such a way that automated segmentation is achieved; sets of known measurements (pixel counting, etc.) are implemented as methods which demonstrate aspects of biology in a reliable fashion; components for automated positioning, focusing, imaging and processing of a multiplicity of samples are integrated as systems within which the segmentation and measurement methods may be mounted; and components and methods are adapted into systems which yield more highly automated and more rapid cell screening.

摘要翻译： 一种用于在药物发现中进行自动细胞筛选的系统，包括自动显微镜，快速自动对焦装置和数字成像系统。 过程在软件中实现，通过该软件，相关的细胞材料通过最小的用户交互被分段和量化。 以下领域的改进：图像处理的已知方法以实现自动分割的方式实现; 已知测量的集合（像素计数等）被实现为以可靠的方式示出生物学方面的方法; 将多个样本的自动定位，聚焦，成像和处理的组件集成为其中可以安装分割和测量方法的系统; 并且组件和方法被适应成产生更高度自动化和更快速的细胞筛选的系统。

公开(公告)号：US20090074283A1

公开(公告)日：2009-03-19

申请号：US12253275

申请日：2008-10-17

申请人： PETER RAMM ,  Yuriy Alexandrov ,  Jurich Cybuch ,  Paul Donders ,  Carlos Zarate ,  Bohdan J. Soltys

发明人： PETER RAMM ,  Yuriy Alexandrov ,  Jurich Cybuch ,  Paul Donders ,  Carlos Zarate ,  Bohdan J. Soltys

IPC分类号： G06K9/00

CPC分类号： G01N21/6458 ,  G01N15/1475 ,  G01N21/6428 ,  G01N33/5026 ,  G01N2015/1497 ,  G01N2333/4603 ,  G06K9/00127 ,  G06T7/0012 ,  G06T7/187 ,  G06T2207/10056 ,  G06T2207/30024

摘要： A system for performing automated cell screening in drug discovery, includes an automated microscope, a fast autofocus device, and a digital imaging system. Processes are implemented in software through which relevant cellular material is segmented and quantified with minimal user interaction. Improvements in the following areas: known methods for image processing are implemented in such a way that automated segmentation is achieved; sets of known measurements (pixel counting, etc.) are implemented as methods which demonstrate aspects of biology in a reliable fashion; components for automated positioning, focusing, imaging and processing of a multiplicity of samples are integrated as systems within which the segmentation and measurement methods may be mounted; and components and methods are adapted into systems which yield more highly automated and more rapid cell screening.

摘要翻译： 用于在药物发现中进行自动细胞筛选的系统包括自动显微镜，快速自动对焦装置和数字成像系统。 过程在软件中实现，通过该软件，相关的细胞材料通过最少的用户交互被分段和量化。 以下领域的改进：图像处理的已知方法以实现自动分割的方式实现; 已知测量的集合（像素计数等）被实现为以可靠的方式示出生物学方面的方法; 将多个样本的自动定位，聚焦，成像和处理的组件集成为其中可以安装分割和测量方法的系统; 并且组件和方法被适应成产生更高度自动化和更快速的细胞筛选的系统。

公开(公告)号：US09057701B2

公开(公告)日：2015-06-16

申请号：US12817422

申请日：2010-06-17

申请人： Peter Ramm ,  Yuriy Alexandrov ,  Paul Donders ,  Carlos Zarate ,  Bohdan J. Soltys

发明人： Peter Ramm ,  Yuriy Alexandrov ,  Jurich Cybuch ,  Paul Donders ,  Carlos Zarate ,  Bohdan J. Soltys

IPC分类号： G06K9/00 ,  G01N21/64 ,  G01N15/14 ,  G01N33/50 ,  G06T7/00

CPC分类号： G01N21/6458 ,  G01N15/1475 ,  G01N21/6428 ,  G01N33/5026 ,  G01N2015/1497 ,  G01N2333/4603 ,  G06K9/00127 ,  G06T7/0012 ,  G06T7/187 ,  G06T2207/10056 ,  G06T2207/30024

摘要： A system for performing automated cell screening in drug discovery, includes an automated microscope, a fast autofocus device, and a digital imaging system. Processes are implemented in software through which relevant cellular material is segmented and quantified with minimal user interaction. Improvements in the following areas: known methods for image processing are implemented in such a way that automated segmentation is achieved; sets of known measurements (pixel counting, etc.) are implemented as methods which demonstrate aspects of biology in a reliable fashion; components for automated positioning, focusing, imaging and processing of a multiplicity of samples are integrated as systems within which the segmentation and measurement methods may be mounted; and components and methods are adapted into systems which yield more highly automated and more rapid cell screening.

摘要翻译： 用于在药物发现中进行自动细胞筛选的系统包括自动显微镜，快速自动对焦装置和数字成像系统。 过程在软件中实现，通过该软件，相关的细胞材料通过最小的用户交互被分段和量化。 以下领域的改进：图像处理的已知方法以实现自动分割的方式实现; 已知测量的集合（像素计数等）被实现为以可靠的方式示出生物学方面的方法; 将多个样本的自动定位，聚焦，成像和处理的组件集成为其中可以安装分割和测量方法的系统; 并且组件和方法被适应成产生更高度自动化和更快速的细胞筛选的系统。