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    Process for the manufacture of 4-acyloxy-3-hydroxyethyl-azetidinones
    2.
    发明授权
    Process for the manufacture of 4-acyloxy-3-hydroxyethyl-azetidinones 失效
    4-酰氧基-3-羟乙基 - 氮杂环丁酮的制备方法

    公开(公告)号：US5274188A

    公开(公告)日：1993-12-28

    申请号：US740685

    申请日：1991-08-06

    申请人： Peter Schneider ,  Gerardo Ramos

    发明人： Peter Schneider ,  Gerardo Ramos

    IPC分类号： C07D205/08 ,  C07D265/08 ,  C07C229/08 ,  C07C229/34

    CPC分类号： C07D265/08 ,  C07D205/08

    摘要： The invention relates to a novel process for the manufacture of (3R,1'R)-4-acyloxy-3-(1'-hydroxyethyl)-2-azetidinones of formula ##STR1## in which R.sup.1 represents lower alkyl or aryl, by enantioselective reduction of the carbonyl group in a suitable .alpha.-acylaminomethyl-acetoacetic acid ester, cyclisation of the resulting .alpha.-acylaminomethyl-.beta.-hydroxybutyric acid ester to a 5,6-dihydro-1,3,4H-oxazine with inversion of the carbon atom carrying the hydroxy group, equilibration to form the preferred trans-substituted dihydrooxazine, recleaving to form the configuratively uniform .alpha.-aminomethyl-.beta.-hydroxybutyric acid, ring-closure to form the .beta.-lactam and oxidative acylation at C(4) of the .beta.-lactam. Compounds of formula I can be used as starting materials for the manufacture of .beta.-lactam antibiotics. The invention relates also to novel intermediates.

    摘要翻译： 本发明涉及制备式（I）的（3R，1'R）-4-酰氧基-3-（1'-羟乙基）-2-氮杂环丁酮的新方法，其中R 1表示低级烷基或 芳基，通过在合适的α-酰基氨基甲基 - 乙酰乙酸酯中羰基的对映选择性还原，将所得的α-酰基氨基甲基-β-羟基丁酸酯环化为具有反相的5,6-二氢-1,3,4H-恶嗪 的带有羟基的碳原子，平衡形成优选的反式取代的二氢恶嗪，重新形成形成均匀的α-氨基甲基-β-羟基丁酸，闭环形成β-内酰胺和C（4）的氧化酰化 ）的β-内酰胺。 式I化合物可用作制备β-内酰胺抗生素的起始原料。 本发明还涉及新颖的中间体。

    Process for the manufacture of 4-acyloxy-3-hydroxyethyl-azetidinones
    3.
    发明授权
    Process for the manufacture of 4-acyloxy-3-hydroxyethyl-azetidinones 失效
    4-酰氧基-3-羟乙基 - 氮杂环丁酮的制备方法

    公开(公告)号：US5386029A

    公开(公告)日：1995-01-31

    申请号：US92736

    申请日：1993-07-16

    申请人： Peter Schneider ,  Gerardo Ramos

    发明人： Peter Schneider ,  Gerardo Ramos

    IPC分类号： C07D205/08 ,  C07D265/08 ,  C07D265/06

    CPC分类号： C07D265/08 ,  C07D205/08

    摘要： The invention relates to a novel process for the manufacture of (3R,1'R)-4-acyloxy-3-(1'-hydroxyethyl)-2-azetidinones of formula ##STR1## in which R.sup.1 represents lower alkyl or aryl, by enantioselective reduction of the carbonyl group in a suitable .alpha.-acylaminomethyl-acetoacetic acid ester, cyclization of the resulting .alpha.-acylaminomethyl-.beta.-hydroxybutyric acid ester to a 5,6-dihydro-1,3,4H-oxazine with inversion of the carbon atom carrying the hydroxy group, equilibration to form the preferred trans-substituted dihydrooxazine, recleaving to form the configuratively uniform .alpha.-aminomethyl-.beta.-hydroxybutyric acid, ring-closure to form the .beta.-lactam and oxidative acylation at C(4) of the .beta.-lactam. Compounds of formula I can be used as starting materials for the manufacture of .beta.-lactam antibiotics. The invention relates also to novel intermediates.

    摘要翻译： 本发明涉及制备式（I）的（3R，1'R）-4-酰氧基-3-（1'-羟乙基）-2-氮杂环丁酮的新方法，其中R 1表示低级烷基或 芳基，通过在合适的α-酰基氨基甲基 - 乙酰乙酸酯中羰基的对映选择性还原，将所得的α-酰基氨基甲基-β-羟基丁酸酯与反应物环化为5,6-二氢-1,3,4H-恶嗪 的带有羟基的碳原子，平衡形成优选的反式取代的二氢恶嗪，重新形成形成均匀的α-氨基甲基-β-羟基丁酸，闭环形成β-内酰胺和C（4）的氧化酰化 ）的β-内酰胺。 式I化合物可用作制备β-内酰胺抗生素的起始原料。 本发明还涉及新颖的中间体。

    Novel process for the manufacture of 4-acyloxy-3-hydroxyethyl-azetidinones
    5.
    发明授权
    Novel process for the manufacture of 4-acyloxy-3-hydroxyethyl-azetidinones 失效
    用于制备4-酰氧基-3-羟乙基 - 氮杂环丁酮的新方法

    公开(公告)号：US4927507A

    公开(公告)日：1990-05-22

    申请号：US186547

    申请日：1988-04-27

    申请人： Peter Schneider ,  Gerardo Ramos ,  Jacques Bersier

    发明人： Peter Schneider ,  Gerardo Ramos ,  Jacques Bersier

    IPC分类号： C12P13/00 ,  C07C67/00 ,  C07C227/00 ,  C07C227/16 ,  C07C227/18 ,  C07C229/22 ,  C07D205/08 ,  C07D265/08 ,  C07D499/06 ,  C07D499/88 ,  C07D499/897 ,  C12P13/02 ,  C12P17/10 ,  C25B3/02

    CPC分类号： C07D205/08 ,  C07D265/08 ,  Y10S435/942

    摘要： The invention relates to a novel process for the manufacture of (3R,1'R)-4-acyloxy-3-(1'-hydroxyethyl)-2-azetidinones of formula ##STR1## in which R.sup.1 represents lower alkyl or aryl, by enantioselective reduction of the carbonyl group in a suitable .alpha.-acylaminomethyl-acetoacetic acid ester, cyclization of the resulting .alpha.-acylaminomethyl-.beta.-hydroxybutyric acid ester to a 5,6-dihydro-1,3,4H-oxazine with inversion of the carbon atom carrying the hydroxy group, equilibration to form the preferred trans-substituted dihydrooxazine, recleaving to form the configuratively uniform .alpha.-aminomethyl-.beta.-hydroxybutyric acid, ring-closure to form the .beta.-lactam and oxidative acylation at C(4) of the .beta.-lactam. Compounds of formula I can be used as starting materials for the manufacture of .beta.-lactam antibiotics. The invention relates also to novel intermediates.

    摘要翻译： 本发明涉及制备式（I）的（3R，1'R）-4-酰氧基-3-（1'-羟乙基）-2-氮杂环丁酮的新方法，其中R 1表示低级烷基或 芳基，通过在合适的α-酰基氨基甲基 - 乙酰乙酸酯中羰基的对映选择性还原，将所得的α-酰基氨基甲基-β-羟基丁酸酯与反应物环化为5,6-二氢-1,3,4H-恶嗪 的带有羟基的碳原子，平衡形成优选的反式取代的二氢恶嗪，重新形成形成均匀的α-氨基甲基-β-羟基丁酸，闭环形成β-内酰胺和C（4）的氧化酰化 ）的β-内酰胺。 式I化合物可用作制备β-内酰胺抗生素的起始原料。 本发明还涉及新颖的中间体。

    Endovascular implant
    7.
    发明授权
    Endovascular implant 有权
    血管内植入

    公开(公告)号：US09375327B2

    公开(公告)日：2016-06-28

    申请号：US13153257

    申请日：2011-06-03

    申请人： Robert Giasolli ,  Peter Schneider

    发明人： Robert Giasolli ,  Peter Schneider

    IPC分类号： A61F2/848 ,  A61F2/88 ,  A61F2/89 ,  A61F2/91 ,  A61F2/958 ,  A61F2/82 ,  A61F2/966

    CPC分类号： A61F2/848 ,  A61F2/844 ,  A61F2/88 ,  A61F2/89 ,  A61F2/91 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/823 ,  A61F2002/825 ,  A61F2002/826 ,  A61F2002/8483 ,  A61F2002/8486 ,  A61F2002/91508 ,  A61F2002/91575 ,  A61F2002/91583 ,  A61F2002/9665 ,  A61F2220/0016 ,  A61F2220/0066

    摘要： A plaque tack can be used for holding plaque against blood vessel walls such as in treating atherosclerotic occlusive disease. The plaque tack can be formed as a thin, annular band for holding loose plaque under a spring or other expansion force against a blood vessel wall. Focal elevating elements and/or other features, such as anchors, can be used to exert a holding force on a plaque position while minimizing the amount of material surface area in contact with the plaque or blood vessel wall and reducing the potential of friction with the endoluminal surface. This approach offers clinicians the ability to perform a minimally invasive post-angioplasty treatment and produce a stent-like result without using a stent.

    摘要翻译： 斑块粘性可用于保持血管壁的斑块，例如治疗动脉粥样硬化闭塞性疾病。 斑块粘性可以形成为薄的环形带，用于在弹簧或其他膨胀力下抵靠血管壁保持松弛的斑块。 可以使用焦点升降元件和/或其他特征（例如锚固件）来在斑块位置施加保持力，同时最小化与斑块或血管壁接触的材料表面积的量，并减少与 腔内表面。 这种方法为临床医生提供了进行微创后血管成形术治疗的能力，并且在不使用支架的情况下产生支架样结果。

    Client-side statement cache
    8.
    发明授权
    Client-side statement cache 有权
    客户端语句缓存

    公开(公告)号：US08832143B2

    公开(公告)日：2014-09-09

    申请号：US12970243

    申请日：2010-12-16

    申请人： Ghazi Nourdine Benadjaoud ,  Peter Schneider

    发明人： Ghazi Nourdine Benadjaoud ,  Peter Schneider

    IPC分类号： G06F17/30

    CPC分类号： G06F17/30864 ,  G06F17/30457 ,  G06Q30/02

    摘要： Embodiments include a method, apparatus and computer program product for providing instructions from a database client to a database server. The method includes the steps of receiving from a database a representation of a first instruction and an associated identifier. The representation of the first instruction and the associated identifier are stored in a cache. A second instruction, from an application, is matched with the representation of the first instruction stored in the cache. The associated identifier is retrieved from the cache based on the matching and the associated identifier is sent to the database server. Upon receipt of the associated identifier, the database server executes the first instruction.

    摘要翻译： 实施例包括用于从数据库客户机向数据库服务器提供指令的方法，装置和计算机程序产品。 该方法包括以下步骤：从数据库接收第一指令和相关标识符的表示。 第一指令和相关联的标识符的表示被存储在高速缓存中。 来自应用的第二条指令与存储在高速缓存中的第一条指令的表示相匹配。 基于匹配从高速缓存检索相关联的标识符，并将相关联的标识符发送到数据库服务器。 在接收到相关联的标识符之后，数据库服务器执行第一条指令。

    Method for wireless data transmission between a base station and a passive transponder, as well as a passive transponder
    9.
    发明授权
    Method for wireless data transmission between a base station and a passive transponder, as well as a passive transponder 有权
    基站与被动应答器之间的无线数据传输方法以及无源应答器

    公开(公告)号：US08699560B2

    公开(公告)日：2014-04-15

    申请号：US13434591

    申请日：2012-03-29

    申请人： Martin Berhorst ,  Alexander Kurz ,  Peter Schneider

    发明人： Martin Berhorst ,  Alexander Kurz ,  Peter Schneider

    IPC分类号： H03K9/06

    CPC分类号： H04B5/02 ,  H04B5/0068 ,  H04B5/0075

    摘要： A method for wireless data transmission, in, for example, RFID systems, between a base station and a passive transponder, as well as a passive transponder is provided by inductive coupling, as well as a passive transponder. It is possible to transmit data from the base station to the transponder by a first data transmission protocol type and by at least one second data transmission protocol type, whereby the first or the at least second data transmission protocol type is selected by writing a configuration register in the transponder.

    摘要翻译： 通过电感耦合以及无源应答器提供了在基站和无源应答器之间的无线数据传输方法，例如RFID系统以及无源应答器。 可以通过第一数据传输协议类型和至少一个第二数据传输协议类型从基站向应答器发送数据，由此通过写配置寄存器来选择第一或至少第二数据传输协议类型 在转发器中。