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公开(公告)号：US20110311746A1
公开(公告)日：2011-12-22
申请号：US13151866
申请日：2011-06-02
Applicant: Peter X. Ma , Haiyun Ma
Inventor： Peter X. Ma , Haiyun Ma
CPC classification number: A61L27/56 , A61F2/06 , A61F2240/004 , Y10T428/139 , Y10T428/1393
Abstract: Various embodiments of scaffolds are disclosed herein. In one embodiment, the scaffold includes a tubular polymeric structure, and a controlled gradient of solid-walled microtubules oriented radially or axially in the tubular polymeric structure. In another embodiment, the scaffold includes a nano-fibrous tubular polymeric structure, and an oriented and interconnected microtubular porous network formed in the nano-fibrous tubular polymeric structure. In still another embodiment, a composite scaffold is formed including a polymeric structure having an inner wall and an outer wall, and at least one electrospun layer positioned along at least one of the inner wall, or the outer wall, or in a middle of the porous polymeric structure.
Abstract translation: 本文公开了支架的各种实施方案。 在一个实施方案中，支架包括管状聚合物结构和在管状聚合物结构中径向或轴向取向的固体壁微管的受控梯度。 在另一个实施方案中，支架包括纳米纤维管状聚合物结构，以及形成在纳米纤维状管状聚合物结构中的定向和互连的微管状多孔网。 在另一个实施方案中，形成复合支架，其包括具有内壁和外壁的聚合物结构，以及至少一个沿着内壁或外壁中的至少一个定位的电纺丝层，或者在 多孔聚合物结构。
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公开(公告)号：US20080268059A1
公开(公告)日：2008-10-30
申请号：US12038783
申请日：2008-02-27
Applicant: Peter X. Ma , Guobao Wei
Inventor： Peter X. Ma , Guobao Wei
CPC classification number: B01D67/0004 , B01D67/0083 , B01D2323/22 , Y10T428/25 , Y10T428/254
Abstract: A method for immobilizing micro-particles, nano-particles or combinations thereof onto a surface is disclosed. The method includes distributing the micro-particles, nano-particles or combinations thereof onto the surface. The surface and the particles are exposed to thermal treatment, vapor treatment or combinations thereof, thereby adhering at least some of the micro-particles, nano-particles or combinations thereof to the surface. Materials including such immobilized micro-particles, nano-particles or combinations thereof are also disclosed herein.
Abstract translation: 公开了将微粒，纳米颗粒或其组合固定在表面上的方法。 该方法包括将微粒，纳米颗粒或其组合分布到表面上。 表面和颗粒暴露于热处理，蒸汽处理或其组合，从而将至少一些微粒，纳米颗粒或其组合粘附到表面上。 包括这种固定化微粒，纳米颗粒或其组合的材料也在本文中公开。
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公开(公告)号：US06979702B1
公开(公告)日：2005-12-27
申请号：US09936692
申请日：2000-03-16
Applicant: Peter X. Ma , Anne E. Huber
Inventor： Peter X. Ma , Anne E. Huber
CPC classification number: A61K6/0835 , C08L33/00 , C08L25/04 , C08L27/06 , C08L31/04
Abstract: An ionomer composite composition having improved and unique physical properties, includes a glass material containing at least one of divalent cations and multivalent cations; and at least one copolymer. The copolymer comprises: at least one hydrophilic monomer containing acid functional groups adapted to react with the at least one of divalent cations and multivalent cations to form ionic crosslinks among polymer chains, the hydrophilic monomer present in an amount sufficient to impart a desired degree of aqueous solubility to the copolymer, and at least one hydrophobic monomer present in an amount sufficient to impart a desired degree of structural stability to the composite composition when exposed to an aqueous environment.
Abstract translation: 具有改进且独特物理性质的离聚物复合组合物包括含有二价阳离子和多价阳离子中的至少一种的玻璃材料; 和至少一种共聚物。 共聚物包括：至少一种含有酸官能团的亲水单体，其适于与二价阳离子和多价阳离子中的至少一种反应以在聚合物链之间形成离子交联，所述亲水单体的存在量足以赋予所需程度的水溶液 对共聚物的溶解度以及当暴露于水性环境时，足以赋予复合组合物所需程度的结构稳定性的量的至少一种疏水性单体。
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公开(公告)号：US06673285B2
公开(公告)日：2004-01-06
申请号：US09853478
申请日：2001-05-11
Applicant: Peter X. Ma
Inventor： Peter X. Ma
IPC: B29C6720
CPC classification number: B29C67/20 , B01J20/285 , B01J20/305 , B01J2220/54 , B29C67/202 , C08J9/26 , G01N30/482 , Y10T29/4998
Abstract: 3-D biodegradable porous, polymer (natural or synthetic) scaffolds with well-controlled, interconnected pores, and method for forming the porous materials. Hydrophilic and/or hydrophobic porogen materials were fabricated into 3-D negative replicas of the desired macroporous architectures. Biodegradable polymers (PLLA and PLGA) were dissolved in a solvent and cast onto the negative replica. After dissolving/leaching out the porogen materials, a porous polymer scaffold was formed. The skeletal structure of PLLA foams consisted of small platelets or nano-fibers, while PLGA foams had homogeneous skeletal structure. To improve the cell seeding, distribution, mass transport, and new tissue organization and vascularization, 3-D macroporous architectures are built in the nano-fibrous matrices. The method tailors polymer scaffolds for a variety of potential tissue engineering applications due to the well-controlled architecture, inter-pore connectivity, and mechanical properties.
Abstract translation: 具有良好控制的互连孔的3-D可生物降解的多孔，聚合物（天然或合成）支架以及用于形成多孔材料的方法。 将亲水和/或疏水致孔剂材料制成所需大孔结构的3-D阴性复制品。 将可生物降解聚合物（PLLA和PLGA）溶解在溶剂中并浇注到阴性复制品上。 在溶解/浸出致孔剂材料后，形成多孔聚合物支架。 PLLA泡沫的骨架结构由小片状或纳米纤维组成，而PLGA泡沫具有均匀的骨架结构。 为了改善细胞接种，分布，质量传递和新组织组织和血管形成，纳米纤维基质中建立了3维大孔结构。 该方法由于具有良好控制的结构，孔间连通性和机械性能而为各种潜在的组织工程应用量身定制聚合物支架。
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公开(公告)号：US08916185B2
公开(公告)日：2014-12-23
申请号：US12038783
申请日：2008-02-27
Applicant: Peter X. Ma , Guobao Wei
Inventor： Peter X. Ma , Guobao Wei
CPC classification number: B01D67/0004 , B01D67/0083 , B01D2323/22 , Y10T428/25 , Y10T428/254
Abstract: A method for immobilizing micro-particles, nano-particles or combinations thereof onto a surface is disclosed. The method includes distributing the micro-particles, nano-particles or combinations thereof onto the surface. The surface and the particles are exposed to thermal treatment, vapor treatment or combinations thereof, thereby adhering at least some of the micro-particles, nano-particles or combinations thereof to the surface. Materials including such immobilized micro-particles, nano-particles or combinations thereof are also disclosed herein.
Abstract translation: 公开了将微粒，纳米颗粒或其组合固定在表面上的方法。 该方法包括将微粒，纳米颗粒或其组合分布到表面上。 表面和颗粒暴露于热处理，蒸汽处理或其组合，从而将至少一些微粒，纳米颗粒或其组合粘附到表面上。 包括这种固定化微粒，纳米颗粒或其组合的材料也在本文中公开。
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Patent Agency Ranking
公开(公告)号：US20120308825A1
公开(公告)日：2012-12-06
申请号：US13576731
申请日：2011-02-09
Applicant: Peter X. Ma , Xiaohua Liu
Inventor： Peter X. Ma , Xiaohua Liu
CPC classification number: C08G63/08 , C08G73/028 , C08J3/12 , C08J9/0071 , C08J9/283 , C08J2377/00 , Y10T428/2982
Abstract: Nano-fibrous microspheres and methods for forming them are disclosed herein. In one embodiment the microsphere includes a plurality of nano-fibers aggregated together in a spherical shape; and a plurality of pores formed between at least some of the plurality of nano-fibers. The nano-fibers are formed of star-shaped polymers.
Abstract translation: 本文公开纳米纤维微球及其形成方法。 在一个实施方案中，微球包括以球形聚集在一起的多个纳米纤维; 以及在所述多个纳米纤维中的至少一些之间形成的多个孔。 纳米纤维由星形聚合物形成。
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公开(公告)号：US20100048734A1
公开(公告)日：2010-02-25
申请号：US12543381
申请日：2009-08-18
Applicant: Peter X. Ma , Jianxiang Zhang
Inventor： Peter X. Ma , Jianxiang Zhang
CPC classification number: C08B37/0012 , A61K47/60 , A61K47/6951 , B82Y5/00
Abstract: A water soluble copolymer includes first and second hydrophilic block segments or graft chains. The first hydrophilic block segment or graft chain contains cyclodextrin groups in at least a majority of its repeating units, and the second hydrophilic block segment or graft chain contains repeating units other than cyclodextrin groups. The first and second block segments or graft chains are covalently linked.
Abstract translation: 水溶性共聚物包括第一和第二亲水嵌段链段或接枝链。 第一亲水性嵌段段或接枝链在其至少大部分重复单元中含有环糊精基团，第二亲水嵌段段或接枝链含有除环糊精基团以外的重复单元。 第一和第二块段或接枝链共价连接。
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公开(公告)号：US07151120B2
公开(公告)日：2006-12-19
申请号：US10271489
申请日：2002-10-16
Applicant: Peter X. Ma
Inventor： Peter X. Ma
CPC classification number: B01J20/28023 , B01J20/26 , B01J20/261 , B01J20/262 , B01J20/28007 , B01J20/28033 , B01J20/28047 , B01J20/28057 , B01J20/28069 , B01J20/28078 , B01J20/28085 , B01J20/30 , B01J20/3064 , B29C67/202 , B82Y30/00 , C12P21/06 , Y10T428/249953
Abstract: A method for preparing a highly porous, high surface area degradable or partially degradable material. The method comprises the steps of mixing a degradable or partially degradable polymer with a mixed solvent comprising a first solvent and a second solvent, wherein the mixed solvent comprises a ratio higher than 1:1, first solvent to second solvent; gelling the mixture; and treating the gel under conditions whereby a substantially solvent free porous structure is created having a porosity greater than about 80%; wherein the material is mechanically strong and has a complex porous structure with nano fibrous architecture.
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公开(公告)号：US6146892A
公开(公告)日：2000-11-14
申请号：US162071
申请日：1998-09-28
Applicant: Peter X. Ma , Ruiyun Zhang
Inventor： Peter X. Ma , Ruiyun Zhang
CPC classification number: C08J9/28 , A61L27/18 , A61L27/50 , A61L27/56 , C08J2367/04 , Y10S521/913 , Y10S521/916
Abstract: Methods and compositions are described that provide three-dimensional fibrillar matrices useful as, among other things, structural prosthetics and scaffolds for cells. The porous fibrillar matrices of the present invention have desirable mechanical properties suitable to a variety of applications, including platforms for in vitro cell cultivation, implants for tissue and organ engineering, implants as tendon and facia prosthetics, and product packaging.
Abstract translation: 描述了提供三维纤维基质的方法和组合物，其用作细胞的结构假体和支架等。 本发明的多孔纤维基质具有适合于各种应用的理想的机械性能，包括用于体外细胞培养的平台，用于组织和器官工程的植入物，作为腱和面膜假体的植入物和产品包装。
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公开(公告)号：US09066997B2
公开(公告)日：2015-06-30
申请号：US13151866
申请日：2011-06-02
Applicant: Peter X. Ma , Haiyun Ma
Inventor： Peter X. Ma , Haiyun Ma
CPC classification number: A61L27/56 , A61F2/06 , A61F2240/004 , Y10T428/139 , Y10T428/1393
Abstract: Various embodiments of scaffolds are disclosed herein. In one embodiment, the scaffold includes a tubular polymeric structure, and a controlled gradient of solid-walled microtubules oriented radially or axially in the tubular polymeric structure. In another embodiment, the scaffold includes a nano-fibrous tubular polymeric structure, and an oriented and interconnected microtubular porous network formed in the nano-fibrous tubular polymeric structure. In still another embodiment, a composite scaffold is formed including a polymeric structure having an inner wall and an outer wall, and at least one electrospun layer positioned along at least one of the inner wall, or the outer wall, or in a middle of the porous polymeric structure.
Abstract translation: 本文公开了支架的各种实施方案。 在一个实施方案中，支架包括管状聚合物结构和在管状聚合物结构中径向或轴向取向的固体壁微管的受控梯度。 在另一个实施方案中，支架包括纳米纤维管状聚合物结构，以及形成在纳米纤维状管状聚合物结构中的定向和互连的微管状多孔网。 在另一个实施方案中，形成复合支架，其包括具有内壁和外壁的聚合物结构，以及至少一个沿着内壁或外壁中的至少一个定位的电纺丝层，或者在 多孔聚合物结构。
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