公开(公告)号：US07241266B2

公开(公告)日：2007-07-10

申请号：US10850315

申请日：2004-05-20

申请人： Peter Zhou ,  Dexing Pang ,  William Li

发明人： Peter Zhou ,  Dexing Pang ,  William Li

IPC分类号： A61B5/00 ,  A61B5/05

CPC分类号： A61B5/14865 ,  A61B5/0031 ,  A61B5/14532 ,  A61B2562/08 ,  G06F19/00 ,  G06F19/3418

摘要： Provided is a bio-sensor system which utilizes radio frequency identification technology and which includes a remote transponder in wireless communication with an implantable on-chip transponder. A power supply collects alternating current voltage pulses from an electro-active polymer generator embedded in muscle tissue for generating power for the on-chip transponder. The power supply is specifically adapted to provide a stable and precise sensor reference voltage to a sensor assembly to enhance the accuracy of measurements of a physiological parameter of a patient. The remote transponder receives data representative of the physiological parameter such as glucose concentration levels. The data is processed and transmitted to the remote transponder by the on-chip transponder. The precision and stability of the sensor reference voltage is enhanced by the specific circuit architecture of a glucose sensor to allow for relatively accurate measurement of glucose concentration levels without the use of a microprocessor.

摘要翻译： 提供了一种利用射频识别技术的生物传感器系统，其包括与可植入片上转发器无线通信的远程转发器。 电源从嵌入在肌肉组织中的电活性聚合物发生器收集交流电压脉冲，以产生用于片上转发器的功率。 电源专门适用于向传感器组件提供稳定和精确的传感器参考电压，以增强患者生理参数的测量精度。 远程转发器接收代表诸如葡萄糖浓度水平的生理参数的数据。 数据被片上转发器处理并发送到远程转发器。 传感器参考电压的精度和稳定性通过葡萄糖传感器的具体电路结构得到增强，以允许在不使用微处理器的情况下相对精确地测量葡萄糖浓度水平。

公开(公告)号：US07297112B2

公开(公告)日：2007-11-20

申请号：US11582790

申请日：2006-10-18

申请人： Peter Zhou ,  Dexing Pang ,  William Li

发明人： Peter Zhou ,  Dexing Pang ,  William Li

IPC分类号： A61B5/00 ,  A61B5/05

CPC分类号： A61B5/14865 ,  A61B5/0031 ,  A61B5/14532 ,  A61B2562/08 ,  G06F19/00 ,  G06F19/3418

摘要： Provided is a bio-sensor system which utilizes radio frequency identification technology and which includes a remote transponder in wireless communication with an implantable passively-powered on-chip transponder. The bio-sensor system is specifically adapted to provide a substantially stable and precise sensor reference voltage to a sensor assembly that is included with the on-chip transponder. The remote transponder is also configured to remotely receive data representative of a physiological parameter of the patient as well as identification data and may enable readout of one or more of the physiological parameters that are measured, processed and transmitted by the on-chip transponder upon request by the remote transponder. The precision and stability of the sensor reference voltage is enhanced by the specific circuit architecture of the glucose sensor to allow for relatively accurate measurement of the physiological parameter such as measurement of glucose concentration by a glucose sensor without the use of a microprocessor.

公开(公告)号：US07125382B2

公开(公告)日：2006-10-24

申请号：US10849614

申请日：2004-05-20

申请人： Peter Zhou ,  Dexing Pang ,  William Li

发明人： Peter Zhou ,  Dexing Pang ,  William Li

IPC分类号： A61B5/00 ,  A61B5/05

CPC分类号： A61B5/14865 ,  A61B5/0031 ,  A61B5/14532 ,  A61B2562/08 ,  G06F19/00 ,  G06F19/3418

摘要： Provided is a bio-sensor system which utilizes radio frequency identification technology and which includes a remote transponder in wireless communication with an implantable passively-powered on-chip transponder. The bio-sensor system is specifically adapted to provide a substantially stable and precise sensor reference voltage to a sensor assembly that is included with the on-chip transponder. The remote transponder is also configured to remotely receive data representative of a physiological parameter of the patient as well as identification data and may enable readout of one or more of the physiological parameters that are measured, processed and transmitted by the on-chip transponder upon request by the remote transponder. The precision and stability of the sensor reference voltage is enhanced by the specific circuit architecture of the glucose sensor to allow for relatively accurate measurement of the physiological parameter such as measurement of glucose concentration by a glucose sensor without the use of a microprocessor.

摘要翻译： 提供了一种利用射频识别技术的生物传感器系统，其包括与可植入式被动供电的片上转发器进行无线通信的远程转发器。 生物传感器系统特别地适于向片上转发器附带的传感器组件提供基本上稳定和精确的传感器参考电压。 远程转发器还被配置为远程接收表示患者的生理参数的数据以及识别数据，并且可以使得能够读出由片上应答器根据请求测量，处理和传输的一个或多个生理参数 由远程转发器。 传感器参考电压的精度和稳定性通过葡萄糖传感器的具体电路结构得到增强，以允许相对精确地测量生理参数，例如葡萄糖传感器测量葡萄糖浓度而不使用微处理器。

公开(公告)号：US20080033273A1

公开(公告)日：2008-02-07

申请号：US11872553

申请日：2007-10-15

申请人： Peter Zhou ,  Dexing Pang ,  William Li

发明人： Peter Zhou ,  Dexing Pang ,  William Li

IPC分类号： A61B5/145

CPC分类号： A61B5/14865 ,  A61B5/0031 ,  A61B5/14532 ,  A61B2562/08 ,  G06F19/3418

摘要： Provided is a bio-sensor system which utilizes radio frequency identification technology and which includes a remote transponder in wireless communication with an implantable passively-powered on-chip transponder. The bio-sensor system is specifically adapted to provide a substantially stable and precise sensor reference voltage to a sensor assembly that is included with the on-chip transponder. The remote transponder is also configured to remotely receive data representative of a physiological parameter of the patient as well as identification data and may enable readout of one or more of the physiological parameters that are measured, processed and transmitted by the on-chip transponder upon request by the remote transponder. The precision and stability of the sensor reference voltage is enhanced by the specific circuit architecture of the glucose sensor to allow for relatively accurate measurement of the physiological parameter such as measurement of glucose concentration by a glucose sensor without the use of a microprocessor.

摘要翻译： 提供了一种利用射频识别技术的生物传感器系统，其包括与可植入式被动供电的片上转发器进行无线通信的远程转发器。 生物传感器系统特别地适于向片上转发器附带的传感器组件提供基本上稳定和精确的传感器参考电压。 远程转发器还被配置为远程接收表示患者的生理参数的数据以及识别数据，并且可以使得能够读出由片上应答器根据请求测量，处理和发送的生理参数中的一个或多个 由远程转发器。 传感器参考电压的精度和稳定性通过葡萄糖传感器的具体电路结构得到增强，以允许相对精确地测量生理参数，例如葡萄糖传感器测量葡萄糖浓度而不使用微处理器。

公开(公告)号：US20050261563A1

公开(公告)日：2005-11-24

申请号：US10850315

申请日：2004-05-20

申请人： Peter Zhou ,  Dexing Pang ,  William Li

发明人： Peter Zhou ,  Dexing Pang ,  William Li

IPC分类号： A61B5/00 ,  A61B5/05 ,  A61B5/07

CPC分类号： A61B5/14865 ,  A61B5/0031 ,  A61B5/14532 ,  A61B2562/08 ,  G06F19/00 ,  G06F19/3418

摘要： Provided is a bio-sensor system which utilizes radio frequency identification technology and which includes a remote transponder in wireless communication with an implantable on-chip transponder. A power supply collects alternating current voltage pulses from an electro-active polymer generator embedded in muscle tissue for generating power for the on-chip transponder. The power supply is specifically adapted to provide a stable and precise sensor reference voltage to a sensor assembly to enhance the accuracy of measurements of a physiological parameter of a patient. The remote transponder receives data representative of the physiological parameter such as glucose concentration levels. The data is processed and transmitted to the remote transponder by the on-chip transponder. The precision and stability of the sensor reference voltage is enhanced by the specific circuit architecture of a glucose sensor to allow for relatively accurate measurement of glucose concentration levels without the use of a microprocessor.

摘要翻译： 提供了一种利用射频识别技术的生物传感器系统，其包括与可植入片上转发器无线通信的远程转发器。 电源从嵌入在肌肉组织中的电活性聚合物发生器收集交流电压脉冲，以产生用于片上转发器的功率。 电源专门适用于向传感器组件提供稳定和精确的传感器参考电压，以增强患者生理参数的测量精度。 远程转发器接收代表诸如葡萄糖浓度水平的生理参数的数据。 数据被片上转发器处理并发送到远程转发器。 传感器参考电压的精度和稳定性通过葡萄糖传感器的具体电路结构得到增强，以允许在不使用微处理器的情况下相对精确地测量葡萄糖浓度水平。

公开(公告)号：US20070038054A1

公开(公告)日：2007-02-15

申请号：US11582790

申请日：2006-10-18

申请人： Peter Zhou ,  Dexing Pang ,  William Li

发明人： Peter Zhou ,  Dexing Pang ,  William Li

IPC分类号： A61B5/05

CPC分类号： A61B5/14865 ,  A61B5/0031 ,  A61B5/14532 ,  A61B2562/08 ,  G06F19/00 ,  G06F19/3418

摘要： Provided is a bio-sensor system which utilizes radio frequency identification technology and which includes a remote transponder in wireless communication with an implantable passively-powered on-chip transponder. The bio-sensor system is specifically adapted to provide a substantially stable and precise sensor reference voltage to a sensor assembly that is included with the on-chip transponder. The remote transponder is also configured to remotely receive data representative of a physiological parameter of the patient as well as identification data and may enable readout of one or more of the physiological parameters that are measured, processed and transmitted by the on-chip transponder upon request by the remote transponder. The precision and stability of the sensor reference voltage is enhanced by the specific circuit architecture of the glucose sensor to allow for relatively accurate measurement of the physiological parameter such as measurement of glucose concentration by a glucose sensor without the use of a microprocessor.

摘要翻译： 提供了一种利用射频识别技术的生物传感器系统，其包括与可植入式被动供电的片上转发器进行无线通信的远程转发器。 生物传感器系统特别地适于向片上转发器附带的传感器组件提供基本上稳定和精确的传感器参考电压。 远程转发器还被配置为远程接收表示患者的生理参数的数据以及识别数据，并且可以使得能够读出由片上应答器根据请求测量，处理和传输的一个或多个生理参数 由远程转发器。 传感器参考电压的精度和稳定性通过葡萄糖传感器的具体电路结构得到增强，以允许相对精确地测量生理参数，例如葡萄糖传感器测量葡萄糖浓度而不使用微处理器。

公开(公告)号：US20070183945A1

公开(公告)日：2007-08-09

申请号：US11349445

申请日：2006-02-07

申请人： William Li ,  Rongchang Xin ,  Wing Pang ,  Dobson Okawa

发明人： William Li ,  Rongchang Xin ,  Wing Pang ,  Dobson Okawa

IPC分类号： B01J19/00

CPC分类号： G01N1/38 ,  B01F13/0222 ,  B01F13/0233 ,  B01J2219/00495 ,  B01L7/00 ,  G01N2035/00425

摘要： Method and apparatus for controlling the temperature of one or more reaction vessels in a bio-chemical analyzer comprises a heat-exchange block, preferably made of cast aluminum or the like, and a thermoelectric device for heating or cooling the block to within a desired temperature range. The heat-transfer block cradles one or more reaction vessels in a thermal energy-transferring relationship, and further supports, in a thermal energy-transferring relationship, one or more fluid conduits serving to transmit a liquid or gas to the interior of the reaction vessels. Preferably, the heat-transfer block is cast from aluminum, and the fluid conduits are disposed inside the casting. By supporting the reaction vessel(s) and fluid conduit(s) in a common block, a single thermoelectric device and controller can be used to simultaneously control the respective temperatures of multiple fluid reagents and/or gases, as well as one or more reaction vessels, thereby reducing the power requirements of the thermal control system.

摘要翻译： 用于控制生物化学分析仪中一个或多个反应容器的温度的方法和装置包括优选由铸铝等制成的热交换块和用于将块加热或冷却至所需温度的热电装置 范围。 热传递块以热能传递关系支撑一个或多个反应容器，并且在热能传递关系中进一步支撑用于将液体或气体传输到反应容器内部的一个或多个流体导管 。 优选地，传热块从铝铸造，并且流体导管设置在铸件内部。 通过将反应容器和流体导管支撑在共同的块中，可以使用单个热电装置和控制器来同时控制多个流体试剂和/或气体的相应温度，以及一个或多个反应 容器，从而降低了热控制系统的功率要求。

公开(公告)号：US08029157B2

公开(公告)日：2011-10-04

申请号：US12336352

申请日：2008-12-16

申请人： William Li ,  Jack Li

发明人： William Li ,  Jack Li

IPC分类号： F21S4/00 ,  F21V21/00

CPC分类号： F21V5/048 ,  F21V13/04 ,  F21Y2115/10 ,  G02B19/0028 ,  G02B19/0066 ,  Y10S362/80

摘要： In an embodiment, a light refraction illumination device is disclosed. The light refraction illumination device may comprise or include a support member, and a plurality of lenses associated with the support member, wherein each lens from among the plurality of lenses may comprise or include a plurality of concave surfaces. The light refraction illumination device may further comprise or include at least one light source associated with the support member, wherein the at least one light source is configured to emit light, and wherein the at least one light source is positioned relative to the plurality of lenses such that the light is configured to travel through the plurality of concave surfaces.

摘要翻译： 在一个实施例中，公开了一种光折射照明装置。 光折射照明装置可以包括或包括支撑构件和与支撑构件相关联的多个透镜，其中来自多个透镜中的每个透镜可以包括或包括多个凹面。 光折射照明装置还可以包括或包括与支撑构件相关联的至少一个光源，其中所述至少一个光源被配置为发射光，并且其中所述至少一个光源相对于所述多个透镜定位 使得所述光被配置成行进通过所述多个凹面。

公开(公告)号：US20070086923A1

公开(公告)日：2007-04-19

申请号：US11249192

申请日：2005-10-13

申请人： William Li ,  Rongchang Xin ,  Elgardo Echevarria ,  John Mitchell

发明人： William Li ,  Rongchang Xin ,  Elgardo Echevarria ,  John Mitchell

IPC分类号： B01L3/02

CPC分类号： B01L3/0203 ,  B01L2200/0684 ,  B01L2200/16 ,  B01L2400/0487 ,  G01N35/1002 ,  Y10T436/2575

摘要： A liquid transfer system for transferring liquid from a plurality of containers to a plurality of destinations comprises a plurality of inlet valves. Each inlet valve is operable between an open position allowing liquid from a container to be drawn into the system and a closed position blocking liquid from a container from being drawn into the system. Liquid drawn from each of the liquid containers is delivered to a buffer chamber designed to degas the liquid in the buffer chamber. The buffer chamber leads to a vented feeder chamber that is also adapted to retain a volume of liquid. A chamber connection valve is provided between the buffer chamber and the feeder chamber to allow or block the flow of liquid between the buffer chamber and the feeder chamber. The feeder chamber is connected to a plurality of distribution valves operable to deliver liquid to a plurality of destinations.

摘要翻译： 用于将液体从多个容器传送到多个目的地的液体传送系统包括多个入口阀。 每个入口阀可以在允许来自容器的液体被吸入系统的打开位置和封闭位置之间操作，该封闭位置阻止液体从容器被吸入系统。 从每个液体容器抽出的液体被输送到设计成使缓冲室中的液体脱气的缓冲室。 缓冲室通向通风的进料室，其也适于保持一定体积的液体。 腔室连接阀设置在缓冲室和进料室之间，以允许或阻止液体在缓冲室和给料室之间的流动。 进料室连接到可操作以将液体输送到多个目的地的多个分配阀。

公开(公告)号：US20060216208A1

公开(公告)日：2006-09-28

申请号：US11088157

申请日：2005-03-23

申请人： William Li ,  Craig Veiner ,  Sergio Cabrera

发明人： William Li ,  Craig Veiner ,  Sergio Cabrera

IPC分类号： B01L3/02

CPC分类号： G01N35/1079 ,  B01L3/0293 ,  B01L9/52 ,  G01N2035/0405

摘要： Apparatus for aspirating liquid from a container, e.g., a test tube, having a puncturable stopper includes a pair of stepper motors that share a common linear actuator or drive member. One motor operates to axially advance the linear drive member (preferably a lead screw) to a position in which it serves to position a rigidly connected tube-detector/stripper member in engagement with the top of a stopper on a tube. Thereafter, the second motor operates to move along the surface of the same drive member to advance an aspiration probe through the engaged stopper and into a liquid aspirating position within the tube. Preferably, a linear guide rail, slidably-mounted on a frame that supports the liquid-aspirating apparatus, serves to guide both the movement of the aspiration probe and the linear drive member. As a result of the shared components, the apparatus is highly precise and reliable.