公开(公告)号：US20190233440A1

公开(公告)日：2019-08-01

申请号：US16263185

申请日：2019-01-31

Applicant: PFIZER INC.

Inventor： Simon PLANKEN ,  Hengmiao CHENG ,  Michael Raymond COLLINS ,  Jillian Elyse SPANGLER ,  Alexei BROOUN ,  Andreas MADERNA ,  Cynthia PALMER ,  Maria Angelica LINTON ,  Asako NAGATA ,  Ping CHEN

IPC: C07D519/00 ,  C07D471/04 ,  C07D403/14 ,  C07D487/10 ,  C07D487/04 ,  C07D417/14 ,  A61P35/00

Abstract: Compounds of the general formula: processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

公开(公告)号：US20170015689A1

公开(公告)日：2017-01-19

申请号：US15209574

申请日：2016-07-13

Applicant: PFIZER INC.

Inventor： Ping Chen ,  Hengmiao CHENG ,  Gary Michael Gallego ,  Mehran Jalaie ,  John Charles Kath ,  Suvi Tuula Marjukka Orr ,  Mason Alan PAIRISH

IPC: C07F9/6558 ,  C07D401/14 ,  C07D413/14 ,  C07D403/14

CPC classification number: C07F9/65583 ,  A61K31/5377 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein X, Y, Z, R1-R11, m, n, and p are defined herein. The novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

Abstract translation: 或其药学上可接受的盐，其中X，Y，Z，R 1 -R 11，m，n和p在本文中定义。 新型嘧啶衍生物可用于治疗哺乳动物中异常细胞生长，如癌症。 另外的实施方案涉及含有化合物的药物组合物和使用化合物和组合物治疗哺乳动物异常细胞生长的方法。

公开(公告)号：US20190248767A1

公开(公告)日：2019-08-15

申请号：US16265012

申请日：2019-02-01

Applicant: PFIZER INC.

Inventor： Simon PLANKEN ,  Hengmiao CHENG ,  Michael Raymond COLLINS ,  Jillian Elyse SPANGLER ,  Alexei BROOUN ,  Andreas MADERNA ,  Cynthia PALMER ,  Maria Angelica LINTON ,  Asako NAGATA ,  Ping CHEN

IPC: C07D403/14 ,  C07D487/10 ,  A61P35/00

Abstract: Compounds of the general formula: processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

公开(公告)号：US20150203502A1

公开(公告)日：2015-07-23

申请号：US14675527

申请日：2015-03-31

Applicant: PFIZER INC.

Inventor： Hengmiao CHENG ,  Theodore Otto JOHNSON, JR. ,  John Charles KATH ,  Kevin Kun-Chin LIU ,  Elizabeth Ann LUNNEY ,  Asako NAGATA ,  Sajiv Krishnan NAIR ,  Simon Paul PLANKEN ,  Scott Channing SUTTON

IPC: C07D487/04 ,  C07D473/18 ,  C07D519/00

CPC classification number: C07D487/04 ,  C07D473/18 ,  C07D519/00

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Q, T, V, W, X, Y, Z, ring A, R1, R2, R3, R4, R5, R5a, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17 and m are defined herein. There novel pyrrolopyrimidine and purine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，其中Q，T，V，W，X，Y，Z，环A，R1，R2，R3，R4，R5，R5a，R6，R7 ，R 8，R 9，R 10，R 11，R 12，R 13，R 14，R 15，R 16，R 17和m如本文所定义。 有新的吡咯并嘧啶和嘌呤衍生物可用于哺乳动物治疗异常细胞生长，如癌症。 另外的实施方案涉及含有化合物的药物组合物和使用化合物和组合物治疗哺乳动物异常细胞生长的方法。

公开(公告)号：US20150291604A1

公开(公告)日：2015-10-15

申请号：US14677112

申请日：2015-04-02

Applicant: PFIZER INC.

Inventor： Ping CHEN ,  Hengmiao CHENG ,  Judith Gail DEAL ,  Gary Michael GALLEGO ,  Mehran JALAIE ,  John Charles KATH ,  Suvi Tuula Marjukka ORR ,  Hong SHEN ,  Luke Raymond ZEHNDER

IPC: C07D487/04 ,  A61N5/10 ,  A61K45/06 ,  A61K31/5377 ,  C07F9/6561

CPC classification number: C07D487/04 ,  A61K31/5377 ,  A61K45/06 ,  A61N5/10 ,  C07F9/65616

Abstract: The present invention relates to compounds of formula (X) or pharmaceutically acceptable salts thereof, wherein R1-R50, a, b, d, e, f, g, h, i, j, k, l, o, p, q, r, s, t, u, y, and z are defined herein. The novel dihydropyrrolopyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

Abstract translation: 本发明涉及式（X）化合物或其药学上可接受的盐，其中R 1 -R 50，a，b，d，e，f，g，h，i，j，k，l，o，p，q， r，s，t，u，y和z在本文中定义。 新型二氢吡咯并嘧啶衍生物可用于治疗哺乳动物中异常细胞生长，如癌症。 另外的实施方案涉及含有化合物的药物组合物和使用化合物和组合物治疗哺乳动物异常细胞生长的方法。

公开(公告)号：US20140142316A1

公开(公告)日：2014-05-22

申请号：US13863534

申请日：2013-04-16

Applicant: Pfizer Inc.

Inventor： Hengmiao CHENG ,  Xiao HU ,  Kevin D. JEROME ,  Mark G. OBUKOWICZ ,  Lisa Maria OLSON ,  Paul V. RUCKER ,  Ronald Keith WEBBER

IPC: C07D213/89

CPC classification number: C07D213/89 ,  A61K31/44 ,  C07D213/72 ,  C07F9/58 ,  Y10S514/886

Abstract: The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.

Abstract translation: 本发明涉及式I化合物或其盐，它们是糖皮质激素受体的调节剂。 本发明的化合物和盐可用于治疗由糖皮质激素受体活性介导的病症。