公开(公告)号：US10550200B2

公开(公告)日：2020-02-04

申请号：US15239556

申请日：2016-08-17

Applicant: Pfizer Inc.

Inventor： Debra Pittman ,  James R. Apgar ,  Zong Sean Juo ,  Macy Jin ,  Mark Stahl ,  Gregory J. Carven ,  Matthew Holsti ,  Susan Benard ,  Sunita R. Hett ,  Reema Jasuja

IPC: C07K16/38 ,  A61K38/48 ,  A61K39/395 ,  A61K39/00

Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.

公开(公告)号：US20230416405A1

公开(公告)日：2023-12-28

申请号：US18182619

申请日：2023-03-13

Applicant: Pfizer Inc.

Inventor： Debra Pittman ,  James R. Apgar ,  Zong Sean Juo ,  Macy Jin ,  Mark Stahl ,  Gregory J. Carven ,  Matthew Holsti ,  Susan Benard ,  Sunita R. Hett ,  Reema Jasuja

IPC: C07K16/38 ,  A61K39/00 ,  A61K38/48 ,  A61K39/395

CPC classification number: C07K16/38 ,  A61K39/0011 ,  A61K38/4846 ,  A61K39/3955 ,  C12Y304/21021 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/21 ,  A61K2039/5158 ,  A61K2039/55522 ,  C07K2317/565 ,  C07K2317/622

Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.

公开(公告)号：US11634504B2

公开(公告)日：2023-04-25

申请号：US17102883

申请日：2020-11-24

Applicant: Pfizer Inc.

Inventor： Debra Pittman ,  James R. Apgar ,  Zong Sean Juo ,  Macy Jin ,  Mark Stahl ,  Gregory J. Carven ,  Matthew Holsti ,  Susan Benard ,  Sunita R. Hett ,  Reema Jasuja

IPC: C07K16/38 ,  A61K39/00 ,  A61K38/48 ,  A61K39/395

Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.

公开(公告)号：US20170073428A1

公开(公告)日：2017-03-16

申请号：US15239556

申请日：2016-08-17

Applicant: Pfizer Inc.

Inventor： Debra Pittman ,  James R. Apgar ,  Zong Sean Juo ,  Macy Jin ,  Mark Stahl ,  Gregory J. Carven ,  Matthew Holsti ,  Susan Benard ,  Sunita R. Hett ,  Reema Jasuja

IPC: C07K16/38 ,  A61K38/48 ,  A61K39/395

Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.

Abstract translation: 本发明涉及特异性结合TFPI并抑制其活性的抗体及其抗原结合片段。 这样的抗体和片段可用于治疗出血性疾病和缩短凝血时间。

公开(公告)号：US12168698B2

公开(公告)日：2024-12-17

申请号：US18182619

申请日：2023-03-13

Applicant: Pfizer Inc.

Inventor： Debra Pittman ,  James R. Apgar ,  Zong Sean Juo ,  Macy Jin ,  Mark Stahl ,  Gregory J. Carven ,  Matthew Holsti ,  Susan Benard ,  Sunita R. Hett ,  Reema Jasuja

IPC: C07K16/38 ,  A61K38/48 ,  A61K39/00 ,  A61K39/395

Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.

公开(公告)号：US20210101998A1

公开(公告)日：2021-04-08

申请号：US17102883

申请日：2020-11-24

Applicant: Pfizer Inc.

Inventor： Debra Pittman ,  James R. Apgar ,  Zong Sean Juo ,  Macy Jin ,  Mark Stahl ,  Gregory J. Carven ,  Matthew Holsti ,  Susan Benard ,  Sunita R. Hett ,  Reema Jasuja

IPC: C07K16/38 ,  A61K39/00 ,  A61K39/395 ,  A61K38/48

Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.