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公开(公告)号：US11970524B2
公开(公告)日：2024-04-30
申请号：US17125903
申请日：2020-12-17
Applicant: Pfizer Inc. , Boston Medical Center Corporation
Inventor： Stephen Berasi , Janet Elizabeth Buhlmann , Nathan Higginson-Scott , Michael Shamashkin , Matthew Russo , Stefano V. Gulla , Zong Sean Juo , Sreekumar R. Kodangattil , Weining Lu , Xueping Fan , David J. Salant
IPC: C07K14/705 , A61K38/17 , A61P13/12 , C07H21/04 , C07K19/00 , C12N15/09 , C12N15/11 , C12N15/52 , C12N15/63 , A61K38/00
CPC classification number: C07K14/70503 , A61K38/17 , A61P13/12 , C07H21/04 , C07K19/00 , C12N15/09 , C12N15/11 , C12N15/52 , C12N15/63 , A61K38/00 , C07K2319/30 , C07K2319/31 , C07K2319/70
Abstract: The invention provides recombinant Roundabout Receptor 2 (ROBO2) proteins designed to bind SLIT ligands and prevent their binding to ROBO2 cell surface receptors. Also provided are methods for use of these recombinant ROBO2 proteins.
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公开(公告)号：US11365253B2
公开(公告)日：2022-06-21
申请号：US16614701
申请日：2018-06-08
Applicant: Pfizer Inc. , Boston Medical Center Corporation
Inventor： Stephen Berasi , Janet Elizabeth Buhlmann , Eric M. Bennett , Nathan Higginson-Scott , Huilan Gao , Zong Sean Juo , Stefano V. Gulla , Christine Huard , Sreekumar R. Kodangattil , Jian Li , Weining Lu , Xueping Fan , David J. Salant
IPC: C07H21/04 , C12P21/06 , C12N15/87 , C12N1/20 , C12N15/74 , A61K39/00 , A61K39/395 , C07K16/00 , C07K16/28 , A61P13/12 , C12N15/85
Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to ROBO2, as well as uses, and methods thereof.
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公开(公告)号：US20210214414A1
公开(公告)日：2021-07-15
申请号：US17125903
申请日：2020-12-17
Applicant: Pfizer Inc. , Boston Medical Center Corporation
Inventor： Stephen Berasi , Janet Elizabeth Buhlmann , Nathan Higginson-Scott , Michael Shamashkin , Matthew Russo , Stefano V. Gulla , Zong Sean Juo , Sreekumar R. Kodangattil , Weining Lu , Xueping Fan , David J. Salant
IPC: C07K14/705 , C12N15/11 , C12N15/52 , C12N15/09 , C07K19/00 , C12N15/63 , C07H21/04 , A61K38/17 , A61P13/12
Abstract: The invention provides recombinant Roundabout Receptor 2 (ROBO2) proteins designed to bind SLIT ligands and prevent their binding to ROBO2 cell surface receptors. Also provided are methods for use of these recombinant ROBO2 proteins.
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公开(公告)号：US10550200B2
公开(公告)日：2020-02-04
申请号：US15239556
申请日：2016-08-17
Applicant: Pfizer Inc.
Inventor： Debra Pittman , James R. Apgar , Zong Sean Juo , Macy Jin , Mark Stahl , Gregory J. Carven , Matthew Holsti , Susan Benard , Sunita R. Hett , Reema Jasuja
IPC: C07K16/38 , A61K38/48 , A61K39/395 , A61K39/00
Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.
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公开(公告)号：US20230416405A1
公开(公告)日：2023-12-28
申请号：US18182619
申请日：2023-03-13
Applicant: Pfizer Inc.
Inventor： Debra Pittman , James R. Apgar , Zong Sean Juo , Macy Jin , Mark Stahl , Gregory J. Carven , Matthew Holsti , Susan Benard , Sunita R. Hett , Reema Jasuja
IPC: C07K16/38 , A61K39/00 , A61K38/48 , A61K39/395
CPC classification number: C07K16/38 , A61K39/0011 , A61K38/4846 , A61K39/3955 , C12Y304/21021 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C07K2317/21 , A61K2039/5158 , A61K2039/55522 , C07K2317/565 , C07K2317/622
Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.
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Patent Agency Ranking
公开(公告)号：US20200157212A1
公开(公告)日：2020-05-21
申请号：US16614701
申请日：2018-06-08
Applicant: Pfizer Inc. , Boston Medical Center Corporation
Inventor： Stephen Berasi , Janet Elizabeth Buhlmann , Eric M. Bennett , Nathan Higginson-Scott , Huilan Gao , Zong Sean Juo , Stefano V. Gulla , Christine Huard , Sreekumar R. Kodangattil , Jian Li , Weining Lu , Xueping Fan , David J. Salant
Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to ROBO2, as well as uses, and methods thereof.
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公开(公告)号：US11634504B2
公开(公告)日：2023-04-25
申请号：US17102883
申请日：2020-11-24
Applicant: Pfizer Inc.
Inventor： Debra Pittman , James R. Apgar , Zong Sean Juo , Macy Jin , Mark Stahl , Gregory J. Carven , Matthew Holsti , Susan Benard , Sunita R. Hett , Reema Jasuja
IPC: C07K16/38 , A61K39/00 , A61K38/48 , A61K39/395
Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.
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公开(公告)号：US20170073428A1
公开(公告)日：2017-03-16
申请号：US15239556
申请日：2016-08-17
Applicant: Pfizer Inc.
Inventor： Debra Pittman , James R. Apgar , Zong Sean Juo , Macy Jin , Mark Stahl , Gregory J. Carven , Matthew Holsti , Susan Benard , Sunita R. Hett , Reema Jasuja
IPC: C07K16/38 , A61K38/48 , A61K39/395
Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.
Abstract translation: 本发明涉及特异性结合TFPI并抑制其活性的抗体及其抗原结合片段。 这样的抗体和片段可用于治疗出血性疾病和缩短凝血时间。
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公开(公告)号：US12168698B2
公开(公告)日：2024-12-17
申请号：US18182619
申请日：2023-03-13
Applicant: Pfizer Inc.
Inventor： Debra Pittman , James R. Apgar , Zong Sean Juo , Macy Jin , Mark Stahl , Gregory J. Carven , Matthew Holsti , Susan Benard , Sunita R. Hett , Reema Jasuja
IPC: C07K16/38 , A61K38/48 , A61K39/00 , A61K39/395
Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.
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公开(公告)号：US20210101998A1
公开(公告)日：2021-04-08
申请号：US17102883
申请日：2020-11-24
Applicant: Pfizer Inc.
Inventor： Debra Pittman , James R. Apgar , Zong Sean Juo , Macy Jin , Mark Stahl , Gregory J. Carven , Matthew Holsti , Susan Benard , Sunita R. Hett , Reema Jasuja
IPC: C07K16/38 , A61K39/00 , A61K39/395 , A61K38/48
Abstract: The invention relates to antibodies, and antigen-binding fragments thereof, that specifically bind TFPI and inhibit an activity thereof. Such antibodies and fragments are useful for treating bleeding disorders and shortening clotting time.
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