公开(公告)号：US06733971B2

公开(公告)日：2004-05-11

申请号：US09934035

申请日：2001-08-21

申请人： Philip A. Beachy ,  Ming-Jer Tsai ,  Sophia Tsai ,  Venkatesh Krishnan ,  Chien-Huan Chen

发明人： Philip A. Beachy ,  Ming-Jer Tsai ,  Sophia Tsai ,  Venkatesh Krishnan ,  Chien-Huan Chen

IPC分类号： C12Q168

CPC分类号： C07K14/43577 ,  C07K14/46 ,  C07K14/47 ,  C07K14/4702 ,  G01N33/573 ,  G01N33/6872 ,  G01N2500/00

摘要： The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provided as well as methods for identifying compounds that are phosphatase inhibitors. Methods of treating tumors in a subject by modulating the phosphorylation of the transcription factor are also included.

摘要翻译： 本发明提供与通过磷酸酶脱磷酸化调节的刺猬蛋白信号传导途径相关的转录因子。 还提供了与脱磷酸化转录因子相互作用的刺猬反应元件（HRE）以及用于鉴定作为磷酸酶抑制剂的化合物的方法。 还包括通过调节转录因子的磷酸化来治疗受试者的肿瘤的方法。

公开(公告)号：US07049090B2

公开(公告)日：2006-05-23

申请号：US10677982

申请日：2003-10-01

申请人： Philip A. Beachy ,  Ming-Jer Tsai ,  Sophia Tsai ,  Venkatesh Krishnan ,  Chien-Huan Chen

发明人： Philip A. Beachy ,  Ming-Jer Tsai ,  Sophia Tsai ,  Venkatesh Krishnan ,  Chien-Huan Chen

IPC分类号： C12Q1/48 ,  C12Q1/68 ,  C12Q1/02 ,  G01N33/53

CPC分类号： C07K14/43577 ,  C07K14/46 ,  C07K14/47 ,  C07K14/4702 ,  G01N33/573 ,  G01N33/6872 ,  G01N2500/00

摘要： The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provided as well as methods for identifying compounds that are phosphatase inhibitors. Methods of treating tumors in a subject by modulating the phosphorylation of the transcription factor are also included.

摘要翻译： 本发明提供与通过磷酸酶脱磷酸化调节的刺猬蛋白信号传导途径相关的转录因子。 还提供了与脱磷酸化转录因子相互作用的刺猬反应元件（HRE）以及用于鉴定作为磷酸酶抑制剂的化合物的方法。 还包括通过调节转录因子的磷酸化来治疗受试者的肿瘤的方法。

公开(公告)号：US07829333B2

公开(公告)日：2010-11-09

申请号：US11438933

申请日：2006-05-22

申请人： Philip A. Beachy ,  Ming-Jer Tsai ,  Sophia Tsai ,  Venkatesh Krishnan ,  Chien-Huan Chen

发明人： Philip A. Beachy ,  Ming-Jer Tsai ,  Sophia Tsai ,  Venkatesh Krishnan ,  Chien-Huan Chen

IPC分类号： C12N5/07 ,  C12Q1/68

CPC分类号： C07K14/43577 ,  C07K14/46 ,  C07K14/47 ,  C07K14/4702 ,  G01N33/573 ,  G01N33/6872 ,  G01N2500/00

摘要： The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provided as well as methods for identifying compounds that are phosphatase inhibitors. Methods of treating tumors in a subject by modulating the phosphorylation of the transcription factor are also included.

摘要翻译： 本发明提供与通过磷酸酶脱磷酸化调节的刺猬蛋白信号传导途径相关的转录因子。 还提供了与脱磷酸化转录因子相互作用的刺猬反应元件（HRE）以及用于鉴定作为磷酸酶抑制剂的化合物的方法。 还包括通过调节转录因子的磷酸化来治疗受试者的肿瘤的方法。

公开(公告)号：US20060211114A1

公开(公告)日：2006-09-21

申请号：US11438933

申请日：2006-05-22

申请人： Philip Beachy ,  Ming-Jer Tsai ,  Sophia Tsai ,  Venkatesh Krishnan ,  Chien-Huan Chen

发明人： Philip Beachy ,  Ming-Jer Tsai ,  Sophia Tsai ,  Venkatesh Krishnan ,  Chien-Huan Chen

IPC分类号： A61K38/17 ,  A61K48/00 ,  A61K31/335 ,  C12N15/87

CPC分类号： C07K14/43577 ,  C07K14/46 ,  C07K14/47 ,  C07K14/4702 ,  G01N33/573 ,  G01N33/6872 ,  G01N2500/00

摘要： The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provided as well as methods for identifying compounds that are phosphatase inhibitors. Methods of treating tumors in a subject by modulating the phosphorylation of the transcription factor are also included.