公开(公告)号：US20060068369A1

公开(公告)日：2006-03-30

申请号：US10957095

申请日：2004-09-30

申请人： Philip Coelho ,  Eric Sommer ,  Richard Klosinski ,  Jim Hobbs ,  Pablo Rubinstein

发明人： Philip Coelho ,  Eric Sommer ,  Richard Klosinski ,  Jim Hobbs ,  Pablo Rubinstein

IPC分类号： A01N1/02 ,  A01N1/00 ,  A61M31/00

CPC分类号： A61M1/3693 ,  A61M1/0231 ,  A61M1/0272 ,  A61M1/0281 ,  B04B5/0428 ,  B04B2005/0435

摘要： An apparatus and method for collecting whole blood and then separating it into components for subsequent use or storage. A self-contained bag set is used to collect the sample, which may then be placed into a device adapted to fit into a centrifuge for separation of components. Each component is then sequentially extracted according to density, with a sensor present in the device to control the operation of valves directing the collection of each component. Each component may then be separated into its own storage container.

摘要翻译： 一种用于收集全血，然后将其分离成组件以供随后使用或储存的装置和方法。 使用独立的袋组来收集样品，然后可以将样品放置在适于装配到离心机中用于分离组分的装置中。 然后根据密度依次提取每个组分，传感器存在于装置中以控制导向各组分收集的阀的操作。 然后可以将每个组件分离成其自己的存储容器。

公开(公告)号：US20070151933A1

公开(公告)日：2007-07-05

申请号：US11713449

申请日：2007-03-02

申请人： Philip Coelho ,  Eric Sommer ,  Richard Klosinski ,  Jim Hobbs

发明人： Philip Coelho ,  Eric Sommer ,  Richard Klosinski ,  Jim Hobbs

IPC分类号： B01D21/26

CPC分类号： A61M1/3693 ,  A61M1/0231 ,  A61M1/0272 ,  A61M1/0281 ,  B04B5/0428 ,  B04B2005/0435

摘要： An apparatus and method for collecting whole blood and then separating it into components for subsequent use or storage. A self-contained bag set is used to collect the sample, which may then be placed into a device adapted to fit into a centrifuge for separation of components. Each component is then sequentially extracted according to density, with a sensor present in the device to control the operation of valves directing the collection of each component. Each component may then be separated into its own storage container.

公开(公告)号：US20070179424A1

公开(公告)日：2007-08-02

申请号：US11640138

申请日：2006-12-15

申请人： Pablo Rubinstein ,  Philip Coelho ,  Cladd Stevens

发明人： Pablo Rubinstein ,  Philip Coelho ,  Cladd Stevens

IPC分类号： A61M37/00

CPC分类号： A61K35/14 ,  A01N1/02 ,  A01N1/0263 ,  A61J1/12 ,  A61M1/0209 ,  A61M1/0236 ,  A61M1/0272 ,  A61M1/0281 ,  A61M1/3693 ,  A61M2202/0439 ,  A61M2202/0462 ,  A61M2202/0071

摘要： A therapeutic product formed from a high concentration of white blood cells having a high degree of cell viability. The white blood cells are sequestered from their normal population presence in whole blood by placing the blood into a container and preventing coagulation of the blood, separating the blood into two components, one of which is extremely rich in white blood cells through the use of a reagent and centrifugation, sequestering the white cell concentration, and freezing the white cells.

摘要翻译： 由具有高细胞存活能力的高浓度白细胞形成的治疗产品。 通过将血液置于容器中并防止血液凝结，将血液分离成两部分，其中一种是通过使用 试剂和离心，隔离白细胞浓度，并冷冻白细胞。

公开(公告)号：US20070269887A1

公开(公告)日：2007-11-22

申请号：US11825542

申请日：2007-07-06

申请人： Philip Coelho ,  Bruce Baker ,  John Chapman ,  Junzhi Li ,  Prince Emmanuel ,  Robert Childers

发明人： Philip Coelho ,  Bruce Baker ,  John Chapman ,  Junzhi Li ,  Prince Emmanuel ,  Robert Childers

IPC分类号： C12N5/06 ,  C12M1/00

CPC分类号： A61M1/3693 ,  A61B5/15003 ,  A61B5/150038 ,  A61B5/150045 ,  A61B5/150366 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/153 ,  A61M1/0209 ,  A61M1/0231 ,  A61M1/029 ,  A61M2202/0462 ,  B01D21/262 ,  B01D21/34 ,  B01D2221/10 ,  B04B5/0428

摘要： The invention includes compositions of stem and progenitor cells recovered from bone marrow or cord blood containing most of the viable CD34+ cells and substantially depleted of red blood cells resident in the original sample, without any xenobiotic additives to aid cell separation. The invention also includes a system and method for preparing the compositions. The system includes a bag set and a processing device, which utilizes an optical sensor, microcontroller, servo motor, accelerometer, load cell, and battery. The system and method utilize centrifugation to stratify the cells into layers and then separate and transfer the stem cells into a stem cell bag. The processing device's microcontroller receives input from the device's accelerometer, load cell and optical sensor to direct the metering valve in the bag set to open and close to permit the transfer of as many stems cells as possible with as few red cells as possible.

摘要翻译： 本发明包括从含有大多数活的CD34 +细胞的骨髓或脐血回收的干细胞和祖细胞的组合物，并且基本上不存在驻留在原始样品中的红细胞，而没有任何异生生物添加剂来辅助细胞分离。 本发明还包括用于制备组合物的系统和方法。 该系统包括一个采用光学传感器，微控制器，伺服电机，加速度计，称重传感器和电池的行李箱和处理装置。 该系统和方法利用离心将细胞分层，然后分离并将干细胞转移到干细胞袋中。 处理设备的微控制器接收来自设备的加速度计，称重传感器和光学传感器的输入，以将计量阀引导到袋组中打开和关闭，以允许尽可能少的红细胞转移尽可能多的茎细胞。