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    Blood component separation method and apparatus
    2.
    发明申请
    Blood component separation method and apparatus 有权
    血液成分分离方法及装置

    公开(公告)号：US20060068369A1

    公开(公告)日：2006-03-30

    申请号：US10957095

    申请日：2004-09-30

    申请人： Philip Coelho ,  Eric Sommer ,  Richard Klosinski ,  Jim Hobbs ,  Pablo Rubinstein

    发明人： Philip Coelho ,  Eric Sommer ,  Richard Klosinski ,  Jim Hobbs ,  Pablo Rubinstein

    IPC分类号： A01N1/02 ,  A01N1/00 ,  A61M31/00

    CPC分类号： A61M1/3693 ,  A61M1/0231 ,  A61M1/0272 ,  A61M1/0281 ,  B04B5/0428 ,  B04B2005/0435

    摘要： An apparatus and method for collecting whole blood and then separating it into components for subsequent use or storage. A self-contained bag set is used to collect the sample, which may then be placed into a device adapted to fit into a centrifuge for separation of components. Each component is then sequentially extracted according to density, with a sensor present in the device to control the operation of valves directing the collection of each component. Each component may then be separated into its own storage container.

    摘要翻译： 一种用于收集全血，然后将其分离成组件以供随后使用或储存的装置和方法。 使用独立的袋组来收集样品，然后可以将样品放置在适于装配到离心机中用于分离组分的装置中。 然后根据密度依次提取每个组分，传感器存在于装置中以控制导向各组分收集的阀的操作。 然后可以将每个组件分离成其自己的存储容器。

    Antibodies for providing protection against P. vivax malaria infection
    5.
    发明授权
    Antibodies for providing protection against P. vivax malaria infection 失效
    用于提供针对间日疟原虫疟疾感染的抗体

    公开(公告)号：US5101017A

    公开(公告)日：1992-03-31

    申请号：US34869

    申请日：1987-04-06

    申请人： Pablo Rubinstein ,  Margaret Nichols

    发明人： Pablo Rubinstein ,  Margaret Nichols

    IPC分类号： C07K16/34 ,  C07K16/42

    CPC分类号： C07K16/425 ,  C07K16/34 ,  Y10S530/808 ,  Y10S530/809

    摘要： A monoclonal antibody which identifies the human blood group Duffy (ab) is provided. Such monoclonal antibody blocks the penetration of P. vivax malaria parasite into human red blood cells by virtue of effective blocking of the target molecule of the P. vivax malaria parasite. Such monoclonal antibody has a combining site having the same stereochemistry as the ligand site on P. vivax, and elicits anti-idiotypic antibodies that react with the parasite.

    摘要翻译： 提供了鉴定人血型Duffy（ab）的单克隆抗体。 这种单克隆抗体通过有效阻断间日疟原虫疟疾寄生虫的靶分子，阻断间日疟原虫寄生虫渗入人红细胞。 这样的单克隆抗体具有与间日疟原虫配体位点相同的立体化学结合位点，引发与寄生虫反应的抗独特型抗体。

    Freezing and thawing bag, mold, apparatus and method
    6.
    发明授权
    Freezing and thawing bag, mold, apparatus and method 失效
    冷冻和解冻袋，模具，设备和方法

    公开(公告)号：US06808675B1

    公开(公告)日：2004-10-26

    申请号：US09672074

    申请日：2000-09-28

    申请人： Philip Henry Coelho ,  Pablo Rubinstein

    发明人： Philip Henry Coelho ,  Pablo Rubinstein

    IPC分类号： B29C4302

    CPC分类号： A61J1/10 ,  A61J1/12 ,  A61M1/0277 ,  B29C65/04 ,  B29C65/08 ,  B29C65/48 ,  B29C66/1122 ,  B29C66/1312 ,  B29C66/53262 ,  B29C66/54 ,  B29C66/83221 ,  B29L2031/7148 ,  F25C1/243

    摘要： A bag, method of manufacture and process are disclosed for the cryopreservation of thermolabile substances. The bag is characterized as having substantially uniform thickness throughout its length and height. The bag features a radiused peripheral edge wall for stress relief and to provide the constant cross-section. A peripheral flashing circumscribes the radiused edge wall and provides a suitable purchase area for sealing so that the thus formed bag is less susceptible to fracture particularly when exposed to cryogenic temperatures. The uniform thickness of the bag promulgates uniform heat transfer to and from the contents of the bag in relation to any surrounding medium at a different temperature. The bag affords more space for efficient storage and reduces heat invasion into the contents of the bag when a plurality of bags are placed with their larger planar surfaces in contact with each other.

    摘要翻译： 公开了一种袋，制造方法和方法，用于低温保存不耐热物质。 该袋的特征在于其整个长度和高度具有基本均匀的厚度。 该袋具有一个圆角的外围边缘壁，用于减轻应力，并提供恒定的横截面。 外围闪光灯围绕圆角边缘壁并提供适当的密封采购区域，使得如此形成的袋子不易受到断裂的影响，特别是当暴露于低温时。 袋子的均匀厚度相对于在不同温度下的任何周围介质，均匀地传送到袋子内部和从袋子的内容物传递。 当多个袋子放置在其较大的平面彼此接触的位置时，袋子提供了更多的空间用于有效的储存并且减少热量侵入到袋子的内容物中。

    Freezing and thawing bag, mold, apparatus and method
    7.
    发明授权
    Freezing and thawing bag, mold, apparatus and method 失效
    冷冻和解冻袋，模具，设备和方法

    公开(公告)号：US06232115B1

    公开(公告)日：2001-05-15

    申请号：US08978171

    申请日：1997-11-25

    申请人： Philip Henry Coelho ,  Pablo Rubinstein

    发明人： Philip Henry Coelho ,  Pablo Rubinstein

    IPC分类号： C12M124

    CPC分类号： A61J1/10 ,  A61J1/12 ,  A61M1/0277 ,  B29C65/04 ,  B29C65/08 ,  B29C65/48 ,  B29C66/1312 ,  B29C66/53262 ,  B29C66/54 ,  B29C66/543 ,  B29C66/7394 ,  B29C66/83221 ,  B29L2031/7148 ,  F25C1/243

    摘要： A bag, method of manufacture and process are disclosed for the cryopreservation of thermolabile substances. The bag is characterized as having substantially uniform thickness throughout its length and height. The bag features a radiused peripheral edge wall for stress relief and to provide the constant cross-section. A peripheral flashing circumscribes the radiused edge wall and provides a suitable purchase area for sealing so that the thus formed bag is less susceptible to fracture particularly when exposed to cryogenic temperatures. The uniform thickness of the bag promulgates uniform heat transfer to and from the contents of the bag in relation to any surrounding medium at a different temperature. The bag affords more space for efficient storage and reduces heat invasion into the contents of the bag when a plurality of bags are placed, with their larger planar surfaces, in contact with each other.

    摘要翻译： 公开了一种袋，制造方法和方法，用于低温保存不耐热物质。 该袋的特征在于其整个长度和高度具有基本均匀的厚度。 该袋具有一个圆角的外围边缘壁，用于减轻应力，并提供恒定的横截面。 外围闪光灯围绕圆角边缘壁并提供适当的密封采购区域，使得如此形成的袋子不易受到断裂的影响，特别是当暴露于低温时。 袋子的均匀厚度相对于在不同温度下的任何周围介质，均匀地传送到袋子内部和从袋子的内容物传递。 袋子提供了更多的空间用于有效的存储，并且当放置多个袋子并且它们较大的平坦表面彼此接触时，可以减少热量侵入到袋的内容物中。

    Method and apparatus for cryogenic storage of thermolabile products
    8.
    发明授权
    Method and apparatus for cryogenic storage of thermolabile products 失效
    用于低温储存的不耐热产品的方法和装置

    公开(公告)号：US5964095A

    公开(公告)日：1999-10-12

    申请号：US877763

    申请日：1997-06-16

    申请人： Philip Henry Coelho ,  Terry Wolf ,  Pablo Rubinstein

    发明人： Philip Henry Coelho ,  Terry Wolf ,  Pablo Rubinstein

    IPC分类号： B65D81/38 ,  B65G1/00 ,  B65G1/137 ,  F25C5/14 ,  F25D3/10 ,  F25D25/00 ,  G01N35/00

    CPC分类号： F25D3/10 ,  F25D25/00 ,  F25D3/105 ,  G01N35/0099

    摘要： A device for cryoprotecting thermolabile products. A container (20) receives an annular rack (40) which is sealed by an enclosure (60). The enclosure (60) includes an outer stationary toroid (70) and a rotatable core (90). A robotic arm (160) is adapted to move and is supported by the core (90). The robotic arm (160) accesses an interior of the enclosure (60). An access portal (80) allows removal and placement of thermolabile products constrained by a holder (150). The robotic arm (160) accesses product and holder (150) and embarks upon controlled freezing of the product and its location in the rack (40) until subsequent retrieval. A computer controls the rate of freezing and stores in memory the location of all of the stored products. The robotic arm (160) reads the product in storage to assure the correct product is being accessed.

    摘要翻译： 用于低温保护耐热产品的装置。 容器（20）容纳由壳体（60）密封的环形齿条（40）。 外壳（60）包括外固定环形（70）和可旋转芯（90）。 机械臂（160）适于移动并被芯（90）支撑。 机械手臂（160）进入外壳（60）的内部。 入口入口（80）允许移除和放置由保持器（150）约束的热不稳定产品。 机器人手臂（160）进入产品和支架（150），并开始控制产品的冻结及其在支架（40）中的位置，直到随后的取回。 计算机控制冷冻速率并在存储器中存储所有存储的产品的位置。 机器人手臂（160）在存储器中读取产品，以确保访问正确的产品。

    Method and apparatus for cryogenic storage of thermolabile products
    9.
    发明授权
    Method and apparatus for cryogenic storage of thermolabile products 失效
    用于低温储存的不耐热产品的方法和装置

    公开(公告)号：US5638686A

    公开(公告)日：1997-06-17

    申请号：US393558

    申请日：1995-02-23

    申请人： Philip Henry Coelho ,  Terry Wolf ,  Pablo Rubinstein

    发明人： Philip Henry Coelho ,  Terry Wolf ,  Pablo Rubinstein

    IPC分类号： B65D81/38 ,  B65G1/00 ,  F25C5/14 ,  F25D3/10 ,  F25D25/00 ,  G01N35/00 ,  F25B19/00

    CPC分类号： F25D3/10 ,  F25D25/00 ,  F25D3/105 ,  G01N35/0099

    摘要： A device for cryoprotecting thermolabile products. A container (20) receives an annular rack (40) which is sealed by an enclosure (60). The enclosure (60) includes an outer stationary toroid (70) and a rotatable core (90). A robotic arm (160) is adapted to move and is supported by the core (90). The robotic arm (160) accesses an interior of the enclosure (60). An access portal (80) allows removal and placement of thermolabile products constrained by a holder (150). The robotic arm (160) accesses product and holder (150) and embarks upon controlled freezing of the product and its location in the rack (40) until subsequent retrieval. A computer controls the rate of freezing and stores in memory the location of all of the stored products. The robotic arm (160) reads the product in storage to assure the correct product is being accessed.

    摘要翻译： 用于低温保护耐热产品的装置。 容器（20）容纳由壳体（60）密封的环形齿条（40）。 外壳（60）包括外固定环形（70）和可旋转芯（90）。 机械臂（160）适于移动并被芯（90）支撑。 机械手臂（160）进入外壳（60）的内部。 入口入口（80）允许移除和放置由保持器（150）约束的热不稳定产品。 机器人手臂（160）进入产品和支架（150），并开始控制产品的冻结及其在支架（40）中的位置，直到随后的取回。 计算机控制冷冻速率并在存储器中存储所有存储的产品的位置。 机器人手臂（160）在存储器中读取产品，以确保访问正确的产品。