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公开(公告)号：US20100055735A1
公开(公告)日：2010-03-04
申请号：US12513028
申请日：2007-11-02
申请人： Philip Stewart Low , Wei He , Sumith A. Kularatne
发明人： Philip Stewart Low , Wei He , Sumith A. Kularatne
IPC分类号： C12Q1/06
CPC分类号： G01N33/582 , G01N15/1459 , G01N15/1463 , G01N33/5091 , G01N33/574 , G01N33/57434 , G01N2015/1006 , G01N2015/1438 , G01N2015/149 , G01N2458/00
摘要： The invention relates to a method for diagnosing a disease state mediated by pathogenic cells. The method comprises the steps of combining with an ex vivo patient sample a composition comprising a conjugate or complex of the general formula Ab-X wherein the group Ab comprises a ligand that binds to the pathogenic cells and the group X comprises an imaging agent, and detecting the pathogenic cells that express a receptor for the ligand using flow cytometry.
摘要翻译： 本发明涉及诊断由致病细胞介导的疾病状态的方法。 该方法包括以下步骤：将离体患者样品与包含通式Ab-X的缀合物或复合物的组合物组合，其中组Ab包含与致病细胞结合的配体，X组包含成像剂，以及 使用流式细胞术检测表达配体受体的致病细胞。
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公开(公告)号：US20110288152A1
公开(公告)日：2011-11-24
申请号：US13124448
申请日：2009-10-16
IPC分类号： A61K31/7088 , A61P35/00 , C07K2/00 , A61K31/713 , C07H21/04 , C07H21/02
CPC分类号： A61K51/088 , C12N15/111 , C12N2310/351 , C12N2320/32
摘要： Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for targeting prostate cancer cells. Also described herein are compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
摘要翻译： 本文描述了可用于靶向前列腺癌细胞的前列腺特异性膜抗原（PSMA）结合缀合物。 本文还描述了含有它们的组合物和使用共轭物和组合物的方法。 还描述了制备缀合物和含有它们的组合物的方法。
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公开(公告)号：US20100324008A1
公开(公告)日：2010-12-23
申请号：US12673931
申请日：2008-08-15
IPC分类号： A61K31/555 , C07K2/00 , C07C275/00 , C07C237/00 , C07F3/10
CPC分类号： A61K47/64 , A61K31/426 , A61K31/4745 , A61K31/475 , A61K47/54 , A61K47/542 , A61K47/547 , A61K47/548 , A61K49/0041 , A61K49/0043 , A61K49/0052 , A61K49/0056 , A61K51/04 , A61K51/0402 , A61K51/0489 , A61K51/088 , C07C323/52 , C07D207/416 , C07K5/08
摘要： Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
摘要翻译： 本文描述了可用于递送治疗，诊断和成像剂的前列腺特异性膜抗原（PSMA）结合缀合物。 本文还描述了含有它们的药物组合物和使用缀合物和组合物的方法。 还描述了制备缀合物和含有它们的组合物的方法。
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公开(公告)号：US09193763B2
公开(公告)日：2015-11-24
申请号：US12673931
申请日：2008-08-15
IPC分类号： C07K5/08 , C07D207/416 , C07C323/52 , A61K47/48 , A61K49/00 , A61K51/04
CPC分类号： A61K47/64 , A61K31/426 , A61K31/4745 , A61K31/475 , A61K47/54 , A61K47/542 , A61K47/547 , A61K47/548 , A61K49/0041 , A61K49/0043 , A61K49/0052 , A61K49/0056 , A61K51/04 , A61K51/0402 , A61K51/0489 , A61K51/088 , C07C323/52 , C07D207/416 , C07K5/08
摘要： Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
摘要翻译： 本文描述了可用于递送治疗，诊断和成像剂的前列腺特异性膜抗原（PSMA）结合缀合物。 本文还描述了含有它们的药物组合物和使用缀合物和组合物的方法。 还描述了制备缀合物和含有它们的组合物的方法。
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公开(公告)号：US20220105205A1
公开(公告)日：2022-04-07
申请号：US17112497
申请日：2020-12-04
IPC分类号： A61K49/00 , G01N21/64 , C07K5/087 , C07K5/11 , C07K7/06 , C07K5/062 , C07D209/20 , C07K5/083 , G01N33/574 , C07K7/02 , C07K5/072 , C07K5/078 , C07K5/065 , C07K5/09 , G01N33/58
摘要： The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for their therapeutic and diagnostic use. More specifically, this disclosure provides compounds and methods for diagnosing and treating diseases associated with cells and/or vasculature expressing prostate specific membrane antigen (PSMA), such as prostate cancer and related diseases. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.
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公开(公告)号：US20090012009A1
公开(公告)日：2009-01-08
申请号：US12130121
申请日：2008-05-30
申请人： Philip S. Low , Sumith A. Kularatne
发明人： Philip S. Low , Sumith A. Kularatne
IPC分类号： A61K38/05 , A61K31/519 , A61P29/00
CPC分类号： A61K31/519 , A61K38/05
摘要： A method of treating inflammatory diseases, and compositions and compounds therefor are described. More particularly, a method of treating inflammatory disease states with vitamin-hapten conjugates is described.
摘要翻译： 描述了治疗炎性疾病的方法及其组合物及其化合物。 更具体地，描述了用维生素 - 半抗原共轭物治疗炎性疾病状态的方法。
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