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    Methods for imaging tumor vasculature using conjugates that bind to aminophospholipids
    5.
    发明申请
    Methods for imaging tumor vasculature using conjugates that bind to aminophospholipids 有权
    使用结合氨磷脂的结合物成像肿瘤脉管系统的方法

    公开(公告)号：US20050089523A1

    公开(公告)日：2005-04-28

    申请号：US10988245

    申请日：2004-11-12

    申请人： Philip Thorpe ,  Sophia Ran ,  Rolf Brekken

    发明人： Philip Thorpe ,  Sophia Ran ,  Rolf Brekken

    IPC分类号： A61K39/395 ,  A61K47/48 ,  A61K51/10 ,  C07K16/18

    CPC分类号： A61K51/1027 ,  A01K2217/05 ,  A61K39/395 ,  A61K47/6849 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2319/00 ,  A61K2300/00

    摘要： Disclosed is the surprising discovery that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are specific, accessible and stable markers of the luminal surface of tumor blood vessels. The present invention thus provides aminophospholipid-targeted diagnostic and therapeutic constructs for use in tumor intervention. Antibody-therapeutic agent conjugates and constructs that bind to aminophospholipids are particularly provided, as are methods of specifically delivering therapeutic agents, including toxins and coagulants, to the stably-expressed aminophospholipids of tumor blood vessels, thereby inducing thrombosis, necrosis and tumor regression.

    摘要翻译： 公开了令人惊奇的发现，氨基磷脂，例如磷脂酰丝氨酸和磷脂酰乙醇胺，是肿瘤血管的腔表面的特异性，可接近和稳定的标记物。 因此，本发明提供用于肿瘤干预的氨基磷脂靶向诊断和治疗构建体。 特别是提供了结合氨磷磷脂的抗体治疗剂缀合物和构建体，以及向肿瘤血管的稳定表达的氨基磷脂特异性递送治疗剂（包括毒素和凝结剂）的方法，从而诱导血栓形成，坏死和肿瘤消退。

    Targeting and Imaging Tumor Vasculature Using Conjugates That Bind to Aminophospholipids
    9.
    发明申请
    Targeting and Imaging Tumor Vasculature Using Conjugates That Bind to Aminophospholipids 有权
    使用与氨磷脂结合的缀合物靶向和成像肿瘤血管

    公开(公告)号：US20090191121A1

    公开(公告)日：2009-07-30

    申请号：US12371458

    申请日：2009-02-13

    申请人： Philip E. Thorpe ,  Sophia Ran ,  Rolf A. Brekken

    发明人： Philip E. Thorpe ,  Sophia Ran ,  Rolf A. Brekken

    IPC分类号： A61K51/10 ,  A61K49/00 ,  A61K49/04 ,  A61K49/16

    CPC分类号： A61K51/1027 ,  A01K2217/05 ,  A61K39/395 ,  A61K47/6849 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2319/00 ,  A61K2300/00

    摘要： Disclosed is the surprising discovery that aminophospholipids, such as phosphatidyserine and phosphatidylethanolamine, are specific, accessible and stable markers of the luminal surface of tumor blood vessels. The present invention thus provides aminophospholipid-targeted diagnostic and therapeutic constructs for use in tumor intervention. Antibody-therapeutic agent conjugates and constructs that bind to aminophospholipids are particularly provided, as are methods of specifically delivering therapeutic agents, including toxins and coagulants, to the stably-expressed aminophospholipids of tumor blood vessels, thereby inducing thrombosis, necrosis and tumor regression.

    摘要翻译： 公开了令人惊奇的发现，氨基磷脂，例如磷脂酰丝氨酸和磷脂酰乙醇胺是肿瘤血管的腔表面的特异性，可接近和稳定的标志物。 因此，本发明提供用于肿瘤干预的氨基磷脂靶向诊断和治疗构建体。 特别是提供了结合氨磷磷脂的抗体治疗剂缀合物和构建体，以及向肿瘤血管的稳定表达的氨基磷脂特异性递送治疗剂（包括毒素和凝结剂）的方法，从而诱导血栓形成，坏死和肿瘤消退。