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    Cancer treatment kits using antibodies to aminophospholipids
    1.
    发明授权
    Cancer treatment kits using antibodies to aminophospholipids 有权
    使用氨基磷脂抗体的癌症治疗试剂盒

    公开(公告)号：US08486391B2

    公开(公告)日：2013-07-16

    申请号：US11329293

    申请日：2006-01-10

    申请人： Philip E. Thorpe ,  Sophia Ran

    发明人： Philip E. Thorpe ,  Sophia Ran

    IPC分类号： A61K39/00

    CPC分类号： A61K39/39558 ,  A61K38/00 ,  A61K45/06 ,  A61K47/6849 ,  A61K49/04 ,  A61K49/16 ,  A61K51/1027 ,  A61K51/1093 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/28 ,  C07K16/2836 ,  C07K2319/74

    摘要： Disclosed are the surprising discoveries that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are stable and specific markers accessible on the luminal surface of tumor blood vessels, and that the administration of an anti-aminophospholipid antibody alone is sufficient to induce thrombosis, tumor necrosis and tumor regression in vivo. This invention therefore provides anti-aminophospholipid antibody-based methods and compositions for use in the specific destruction of tumor blood vessels and in the treatment of solid tumors. Although various antibody conjugates and combinations are thus provided, the use of naked, or unconjugated, anti-phosphatidylserine antibodies is a particularly important aspect of the invention, due to simplicity and effectiveness of the approach.

    摘要翻译： 披露了令人惊奇的发现，即氨基磷脂如磷脂酰丝氨酸和磷脂酰乙醇胺是稳定的，特异性标记可在肿瘤血管的腔表面上接近，并且单独给予抗氨基磷脂抗体足以诱导血栓形成，肿瘤坏死和肿瘤 体内回归 因此，本发明提供了用于特异性破坏肿瘤血管和用于治疗实体瘤的基于抗氨基磷脂抗体的方法和组合物。 尽管提供了各种抗体缀合物和组合，但是由于方法的简单性和有效性，使用裸体或非共轭抗磷脂酰丝氨酸抗体是本发明的特别重要的方面。

    Combined cancer treatment methods using antibodies to aminophospholipids
    3.
    发明授权
    Combined cancer treatment methods using antibodies to aminophospholipids 有权
    联合癌症治疗方法使用氨基磷脂抗体

    公开(公告)号：US07422738B2

    公开(公告)日：2008-09-09

    申请号：US09998833

    申请日：2001-11-30

    申请人： Philip E. Thorpe ,  Sophia Ran

    发明人： Philip E. Thorpe ,  Sophia Ran

    IPC分类号： A61K39/395

    CPC分类号： A61K49/16 ,  A61K38/00 ,  A61K47/6849 ,  A61K49/04 ,  A61K49/085 ,  A61K51/1027 ,  A61K51/1093 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/28 ,  C07K16/2836 ,  C07K2319/74

    摘要： Disclosed are the surprising discoveries that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are stable and specific markers accessible on the luminal surface of tumor blood vessels, and that the administration of an anti-aminophospholipid antibody alone is sufficient to induce thrombosis, tumor necrosis and tumor regression in vivo. This invention therefore provides anti-aminophospholipid antibody-based methods and compositions for use in the specific destruction of tumor blood vessels and in the treatment of solid tumors. Although various antibody conjugates and combinations are thus provided, the use of naked, or unconjugated, anti-phosphatidylserine antibodies is a particularly important aspect of the invention, due to simplicity and effectiveness of the approach.

    摘要翻译： 披露了令人惊奇的发现，即氨基磷脂如磷脂酰丝氨酸和磷脂酰乙醇胺是稳定的，特异性标记可在肿瘤血管的腔表面上接近，并且单独的抗氨基磷脂抗体的施用足以诱导血栓形成，肿瘤坏死和肿瘤 体内回归 因此，本发明提供了用于特异性破坏肿瘤血管和用于治疗实体瘤的基于抗氨基磷脂抗体的方法和组合物。 尽管提供了各种抗体缀合物和组合，但是由于方法的简单性和有效性，使用裸体或非共轭抗磷脂酰丝氨酸抗体是本发明的特别重要的方面。

    Cancer treatment methods using antibodies to aminophospholipids
    8.
    发明授权
    Cancer treatment methods using antibodies to aminophospholipids 有权
    使用氨基磷脂抗体的癌症治疗方法

    公开(公告)号：US06406693B1

    公开(公告)日：2002-06-18

    申请号：US09351543

    申请日：1999-07-12

    申请人： Philip E. Thorpe ,  Sophia Ran

    发明人： Philip E. Thorpe ,  Sophia Ran

    IPC分类号： A61K39395

    CPC分类号： A61K49/16 ,  A61K38/00 ,  A61K47/6849 ,  A61K49/04 ,  A61K49/085 ,  A61K51/1027 ,  A61K51/1093 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/28 ,  C07K16/2836 ,  C07K2319/74

    摘要： Disclosed are the surprising discoveries that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are stable and specific markers accessible on the luminal surface of tumor blood vessels, and that the administration of an anti-aminophospholipid antibody alone is sufficient to induce thrombosis, tumor necrosis and tumor regression in vivo. This invention therefore provides anti-aminophospholipid antibody-based methods and compositions for use in the specific destruction of tumor blood vessels and in the treatment of solid tumors. Although various antibody conjugates and combinations are thus provided, the use of naked, or unconjugated, anti-phosphatidylserine antibodies is a particularly important aspect of the invention, due to simplicity and effectiveness of the approach.

    摘要翻译： 披露了令人惊奇的发现，即氨基磷脂如磷脂酰丝氨酸和磷脂酰乙醇胺是稳定的，特异性标记可在肿瘤血管的腔表面上接近，并且单独的抗氨基磷脂抗体的施用足以诱导血栓形成，肿瘤坏死和肿瘤 体内回归 因此，本发明提供了用于特异性破坏肿瘤血管和用于治疗实体瘤的基于抗氨基磷脂抗体的方法和组合物。 尽管提供了各种抗体缀合物和组合，但是由于方法的简单性和有效性，使用裸体或非共轭抗磷脂酰丝氨酸抗体是本发明的特别重要的方面。