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1.发明授权Polysaccharides with antithrombotic activity comprising at least a covalent bond with biotin or a biotin derivative 有权具有抗血栓活性的多糖至少包含与生物素或生物素衍生物的共价键公开(公告)号：US06844329B2
公开(公告)日：2005-01-18
申请号：US10381154
申请日：2001-09-20
IPC分类号： C07H15/04 , A61K20060101 , A61K31/4188 , A61K31/70 , A61K31/7056 , A61K31/715 , A61K31/716 , A61K47/42 , A61P3/00 , A61P3/10 , A61P7/02 , A61P7/04 , A61P9/00 , A61P9/08 , A61P9/10 , A61P11/00 , A61P25/28 , A61P31/04 , A61P31/12 , A61P35/00 , C07H15/00 , C08B20060101 , C08B37/00
CPC分类号： C08B37/006 , A61K31/715 , C08B37/00 , C08B37/0063
摘要： The present invention relates to novel synthetic polysaccharides with antithrombotic activity exhibiting at least one covalent bond with biotin or a biotin derivative and to a process employing avidin or streptavidin which makes it possible to neutralize these polysaccharides.
摘要翻译： 本发明涉及具有与生物素或生物素衍生物至少一个共价键的抗血栓形成活性的新型合成多糖以及使用抗生物素蛋白或链霉抗生物素蛋白的方法，其可以中和这些多糖。
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公开(公告)号：US08703738B2
公开(公告)日：2014-04-22
申请号：US13611753
申请日：2012-09-12
IPC分类号： A61K31/715
CPC分类号： C08B37/00 , A61K31/715 , A61L27/34 , A61L31/10 , C08L5/00
摘要： The invention concerns novel biotinylated hexadecasaccharides of general formula (I) wherein: Biot is a biotin derivative; R, R1 and R2, represent independently of one another a C1-C6 alkoxy or and —OSO3; R3 represents a C1-C6 alkoxy or an —OSO3, or R3 constitutes a —O—CH2— bridge; Pe represents a saccharide concatenation; as well as their pharmaceutically acceptable salts, and their use as medicines.
摘要翻译： 本发明涉及通式（I）的新生物素化的十六碳糖，其中：Biot是生物素衍生物; R，R 1和R 2彼此独立地表示C 1 -C 6烷氧基或-OSO 3; R3表示C1-C6烷氧基或-OSO3，或R3构成-O-CH2-桥; Pe表示糖连接; 以及它们的药学上可接受的盐，以及它们作为药物的用途。
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公开(公告)号：US20130004551A1
公开(公告)日：2013-01-03
申请号：US13611753
申请日：2012-09-12
CPC分类号： C08B37/00 , A61K31/715 , A61L27/34 , A61L31/10 , C08L5/00
摘要： The invention concerns novel biotinylated hexadecasaccharides of general formula (I) wherein: Biot is a biotin derivative; R, R1 and R2, represent independently of one another a C1-C6 alkoxy or and —OSO3; R3 represents a C1-C6 alkoxy or an —OSO3, or R3 constitutes a —O—CH2— bridge; Pe represents a saccharide concatenation; as well as their pharmaceutically acceptable salts, and their use as medicines.
摘要翻译： 本发明涉及通式（I）的新生物素化的十六碳糖，其中：Biot是生物素衍生物; R，R 1和R 2彼此独立地表示C 1 -C 6烷氧基或-OSO 3; R3表示C1-C6烷氧基或-OSO3，或R3构成-O-CH2-桥; Pe表示糖连接; 以及它们的药学上可接受的盐，以及它们作为药物的用途。
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4.发明申请Novel polysaccharides with antithrombotic activity comprising at least one covalent bond with biotin or a biotin derivative 有权具有抗血栓活性的新型多糖包括与生物素或生物素衍生物的至少一个共价键公开(公告)号：US20060160768A1
公开(公告)日：2006-07-20
申请号：US11035717
申请日：2005-01-14
IPC分类号： A61K31/715 , C08B37/00
CPC分类号： C08B37/006 , A61K31/715 , C08B37/00 , C08B37/0063
摘要： The present invention relates to novel synthetic polysaccharides with antithrombotic activity exhibiting at least one covalent bond with biotin or a biotin derivative and to a process employing avidin or streptavidin which makes it possible to neutralize these polysaccharides.
摘要翻译： 本发明涉及具有与生物素或生物素衍生物至少一个共价键的抗血栓形成活性的新型合成多糖以及使用抗生物素蛋白或链霉抗生物素蛋白的方法，其可以中和这些多糖。
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5.发明授权Polysaccharides with antithrombotic activity comprising at least one covalent bond with biotin or a biotin derivative 有权具有抗血栓活性的多糖与生物素或生物素衍生物至少包含一个共价键公开(公告)号：US07943595B2
公开(公告)日：2011-05-17
申请号：US11035717
申请日：2005-01-14
IPC分类号： A61K31/715 , C07K17/10
CPC分类号： C08B37/006 , A61K31/715 , C08B37/00 , C08B37/0063
摘要： The present invention relates to novel synthetic polysaccharides with antithrombotic activity exhibiting at least one covalent bond with biotin or a biotin derivative and to a process employing avidin or streptavidin which makes it possible to neutralize these polysaccharides.
摘要翻译： 本发明涉及具有与生物素或生物素衍生物至少一个共价键的抗血栓形成活性的新型合成多糖以及使用抗生物素蛋白或链霉抗生物素蛋白的方法，其可以中和这些多糖。
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公开(公告)号：US08557968B2
公开(公告)日：2013-10-15
申请号：US12837861
申请日：2010-07-16
CPC分类号： C08B37/00 , A61K31/715 , A61L27/34 , A61L31/10 , C08L5/00
摘要： The invention concerns novel biotinylated hexadecasaccharides of general formula (I) wherein: Biot is a biotin derivative; R, R1 and R2, represent independently of one another a C1-C6 alkoxy or and —OSO3; R3 represents a C1-C6 alkoxy or an —OSO3, or R3 constitutes a —O—CH2— bridge; Pe represents a saccharide concatenation; as well as their pharmaceutically acceptable salts, and their use as medicines.
摘要翻译： 本发明涉及通式（I）的新生物素化的十六碳糖，其中：Biot是生物素衍生物; R，R 1和R 2彼此独立地表示C 1 -C 6烷氧基或-OSO 3; R3表示C1-C6烷氧基或-OSO3，或R3构成-O-CH2-桥; Pe表示糖连接; 以及它们的药学上可接受的盐，以及它们作为药物的用途。
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7.发明授权Polysaccharides with antithrombotic activity comprising at least one covalent bond with biotin or a biotin derivative 有权具有抗血栓活性的多糖与生物素或生物素衍生物至少包含一个共价键公开(公告)号：US08318696B2
公开(公告)日：2012-11-27
申请号：US13036143
申请日：2011-02-28
IPC分类号： A61K31/715 , C07H1/00
CPC分类号： C08B37/006 , A61K31/715 , C08B37/00 , C08B37/0063
摘要： The present invention relates to novel synthetic polysaccharides with antithrombotic activity exhibiting at least one covalent bond with biotin or a biotin derivative and to a process employing avidin or streptavidin which makes it possible to neutralize these polysaccharides.
摘要翻译： 本发明涉及具有与生物素或生物素衍生物至少一个共价键的抗血栓形成活性的新型合成多糖以及使用抗生物素蛋白或链霉抗生物素蛋白的方法，其可以中和这些多糖。
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8.发明申请Novel Polysaccharides with Antithrombotic Activity Comprising at Least One Covalent Bond with Biotin or a Biotin Derivative 有权具有抗生物活性的新型多糖与生物素或生物素衍生物的至少一个共价键组成公开(公告)号：US20110144042A1
公开(公告)日：2011-06-16
申请号：US13036143
申请日：2011-02-28
IPC分类号： A61K31/7028 , A61P7/02
CPC分类号： C08B37/006 , A61K31/715 , C08B37/00 , C08B37/0063
摘要： The present invention relates to novel synthetic polysaccharides with antithrombotic activity exhibiting at least one covalent bond with biotin or a biotin derivative and to a process employing avidin or streptavidin which makes it possible to neutralize these polysaccharides.
摘要翻译： 本发明涉及具有与生物素或生物素衍生物至少一个共价键的抗血栓形成活性的新型合成多糖以及使用抗生物素蛋白或链霉抗生物素蛋白的方法，其可以中和这些多糖。
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9.发明授权公开(公告)号：US06528497B1
公开(公告)日：2003-03-04
申请号：US09600506
申请日：2000-09-05
申请人： Johannes Basten , Cornelia Dreef-Tromp , Pierre Alexandre Driguez , Philippe Duchaussoy , Jean Marc Herbert , Maurice Petitou , Constant Van Boeckel
发明人： Johannes Basten , Cornelia Dreef-Tromp , Pierre Alexandre Driguez , Philippe Duchaussoy , Jean Marc Herbert , Maurice Petitou , Constant Van Boeckel
IPC分类号： A61K31715
CPC分类号： C08B37/0063
摘要： Novel synthetic polysaccharides for use in the treatment of pathologies associated with a coagulation dysfunction.
摘要翻译： 用于治疗与凝血功能障碍有关的病理学的新型合成多糖。
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10.发明授权公开(公告)号：US07919614B2
公开(公告)日：2011-04-05
申请号：US10677894
申请日：2003-10-02
IPC分类号： A61K31/716 , A61K31/737 , C08B11/02 , C07H5/10 , C07H15/04
CPC分类号： C08B37/006 , A61K31/435 , A61K31/445 , A61K31/505 , A61K31/60 , A61K31/715 , A61K45/06 , C08B37/00
摘要： Synthetic polysaccharides are disclosed containing 8-24 monosaccharide units made up of a concatenation of disaccharides consisting of a uronic acid and a hexose, wherein the hydroxyl groups of the polysaccharides are etherified with a C1-6 alkyl group or esterified in the form of a sulpho group, each disaccharide being at least monoetherified; and salts thereof, are disclosed.
摘要翻译： 公开了合成多糖，其含有由糖醛酸和己糖组成的二糖的连接构成的8-24个单糖单元，其中多糖的羟基用C 1-6烷基醚化或以磺酸形式酯化 组，每个二糖至少单醚化; 及其盐。
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