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    Transdermal Electrotransport Delivery Device Including An Antimicrobial Compatible Reservoir Composition
    3.
    发明申请
    Transdermal Electrotransport Delivery Device Including An Antimicrobial Compatible Reservoir Composition 有权
    透皮电传递装置包括一种抗微生物兼容的储层组成

    公开(公告)号：US20070100274A1

    公开(公告)日：2007-05-03

    申请号：US11556413

    申请日：2006-11-03

    申请人： Wendy Young ,  Michel Cormier

    发明人： Wendy Young ,  Michel Cormier

    IPC分类号： A61N1/30

    CPC分类号： A61N1/30

    摘要： A transdermal electrotransport drug delivery device having an anode, a cathode and a source of electrical power electrically connected to the anode and the cathode. At least one of the anode and the cathode includes an electrode and a reservoir comprised of a housing composed of a polymeric material and an aqueous medium in contact with the housing. The aqueous medium includes (i) a drug or an electrolyte salt or a mixture thereof, (ii) propylene glycol, and (iii) an antimicrobial agent in an amount sufficient to inhibit microbial growth in the aqueous medium. The propylene glycol prevents the antimicrobial agent from being adsorbed by other materials used in the construction of the delivery device. A process for preparing a transdermal electrotransport drug delivery device is also provided.

    摘要翻译： 具有电连接到阳极和阴极的阳极，阴极和电源的透皮电运输药物递送装置。 阳极和阴极中的至少一个包括电极和由包含聚合物材料的外壳和与外壳接触的水性介质的容器。 水性介质包括（i）药物或电解质盐或其混合物，（ii）丙二醇，和（iii）足以抑制水性介质中微生物生长的量的抗微生物剂。 丙二醇防止抗微生物剂被用于构建输送装置的其它材料吸附。 还提供了一种制备透皮电转运药物递送装置的方法。

    Apparatus and method for transdermal delivery of epoetin-based agents
    5.
    发明申请
    Apparatus and method for transdermal delivery of epoetin-based agents 审中-公开
    用于透皮递送基于epoetin的药剂的装置和方法

    公开(公告)号：US20060182789A1

    公开(公告)日：2006-08-17

    申请号：US11355856

    申请日：2006-02-15

    申请人： Mahmoud Ameri ,  Michel Cormier ,  Yuh-Fun Maa ,  Peter Daddona

    发明人： Mahmoud Ameri ,  Michel Cormier ,  Yuh-Fun Maa ,  Peter Daddona

    IPC分类号： A61K38/18 ,  A61F13/02 ,  A61M31/00

    CPC分类号： A61M37/0015 ,  A61K9/0021 ,  A61K9/06 ,  A61K38/1816 ,  A61M2037/0023 ,  A61M2037/0046

    摘要： An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, an Epoetin-based agent is contained in a biocompatible coating that is applied to the microprojection member. In a further embodiment, the delivery system includes a gel pack having an Epoetin-based agent-containing hydrogel formulation that is disposed on the microprojection member after application to the skin of a patient. In an alternative embodiment, the Epoetin-based agent is contained in both the coating and the hydrogel formulation.

    摘要翻译： 一种用于透皮递送生物活性剂的装置和方法，包括具有微突出物构件（或系统）的递送系统，所述微突出物构件（或系统）包括多个微突出物（或阵列），所述微突出物构件（或阵列）适于穿透角质层穿入下面的表皮层，或 表皮和真皮层。 在一个实施方案中，基于Epoetin的试剂包含在施加到微喷射构件的生物相容性涂层中。 在另一个实施方案中，递送系统包括具有基于Epoetin的含药剂的水凝胶制剂的凝胶包，其在施用到患者皮肤之后设置在微突出物构件上。 在替代实施方案中，基于Epoetin的试剂包含在涂层和水凝胶制剂中。

    Compositions of stabilized DNA for coating microprojctions
    6.
    发明申请
    Compositions of stabilized DNA for coating microprojctions 审中-公开
    用于涂覆微孔的稳定化DNA的组成

    公开(公告)号：US20050090009A1

    公开(公告)日：2005-04-28

    申请号：US10972230

    申请日：2004-10-21

    申请人： Michel Cormier ,  Georg Widera ,  Mahmoud Ameri

    发明人： Michel Cormier ,  Georg Widera ,  Mahmoud Ameri

    IPC分类号： A61K48/00 ,  C12N15/89 ,  C12N15/87

    CPC分类号： A61K48/0008 ,  A61K48/0025 ,  A61K48/0041 ,  C12N15/89

    摘要： The present invention provides methods and compositions for stabilizing dried nucleic acids with carbohydrates such as non-reducing sugars, polysaccharides, and reducing sugars. Preferably, the stabilized nucleic acids are coated on a microprojection member for transdermal delivery. The invention further provides compositions and methods that involve the use of DNase inhibitors to stabilize dried nucleic acids delivered directly into bodily tissues.

    摘要翻译： 本发明提供了用碳水化合物如非还原糖，多糖和还原糖稳定干燥的核酸的方法和组合物。 优选地，将稳定的核酸涂覆在用于透皮递送的微突出物构件上。 本发明还提供涉及使用DNase抑制剂稳定直接递送到身体组织中的干燥核酸的组合物和方法。

    Composition, device, and method for electrotransport agent delivery
    8.
    发明授权
    Composition, device, and method for electrotransport agent delivery 失效

    公开(公告)号：US5736580A

    公开(公告)日：1998-04-07

    申请号：US338924

    申请日：1994-11-14

    申请人： James A. Huntington ,  Michel Cormier

    发明人： James A. Huntington ,  Michel Cormier

    IPC分类号： A61K9/00 ,  A61K47/10 ,  A61N1/30 ,  A61K31/08

    CPC分类号： A61K47/10 ,  A61K9/0009 ,  A61N1/30

    摘要： An electrotransport drug-containing composition is provided. The composition includes a drug to be delivered through a body surface (eg, skin) of a patient, and a permeation enhancer which is solid or semisolid at temperatures typically encountered during storage of pharmaceuticals (eg, temperatures up to at least about 25.degree. C.). The composition of the invention may be applied from a device 10 suitable for electrotransport delivery. A method for increasing electrotransport agent delivery rate and reducing body surface resistance relies on applying the composition of the invention to the body surface, and applying an electric current through the composition and the body surface.

    Reduction or prevention of skin irritation or sensitization during transdermal administration of a irritating or sensitizing drug
    9.
    发明授权
    Reduction or prevention of skin irritation or sensitization during transdermal administration of a irritating or sensitizing drug 失效
    在透皮给药刺激性或致敏性药物时减少或预防皮肤刺激或致敏

    公开(公告)号：US5451407A

    公开(公告)日：1995-09-19

    申请号：US63176

    申请日：1993-06-21

    申请人： Michel Cormier ,  Alfred Amkraut ,  Philip W. Ledger

    发明人： Michel Cormier ,  Alfred Amkraut ,  Philip W. Ledger

    IPC分类号： A61K9/70 ,  A61K47/22 ,  A61F13/00

    CPC分类号： A61K47/22 ,  A61K9/0014 ,  A61K9/7023

    摘要： The present invention is directed to the transdermal administration of methyl nicotinate and an irritating or sensitizing drug. The invention includes a transdermal drug delivery device comprising a matrix adapted to be placed in irritating/sensitizing drug- and methyl nicotinate-transmitting relation with the skin site. The matrix contains sufficient amounts of irritating/sensitizing drug and of methyl nicotinate, in combination, to continuously administer to the skin for a predetermined period of time the drug to provide an effective therapeutic result. The invention is also directed to a method for either 1) preventing or reducing the irritation caused by an irritating drug or 2) preventing or reducing sensitization from occurring, as well as reducing or eliminating pain and discomfort occurring during the elicitation phase after sensitization has already been induced.

    摘要翻译： 本发明涉及透明给药烟酸甲酯和刺激性或致敏药物。 本发明包括透皮药物递送装置，其包含适于与皮肤部位置于刺激/敏化药物和甲基烟酸酯传递关系中的基质。 基质含有足量的刺激性/致敏药物和烟酸甲酯组合，以持续给予皮肤预定的时间以提供有效的治疗结果。 本发明还涉及以下方法：1）预防或减少由刺激性药物引起的刺激或2）预防或减少致敏发生，以及减轻或消除致敏期间在引发阶段中发生的疼痛和不适 被诱导。

    Intravitreal injection device and system
    10.
    发明授权
    Intravitreal injection device and system 有权
    玻璃体内注射装置和系统

    公开(公告)号：US08221353B2

    公开(公告)日：2012-07-17

    申请号：US12456439

    申请日：2009-06-16

    申请人： Michel Cormier ,  Gholam Peyman ,  Kamran Hosseini

    发明人： Michel Cormier ,  Gholam Peyman ,  Kamran Hosseini

    IPC分类号： A61M5/00

    CPC分类号： A61F9/0017 ,  A61M5/24 ,  A61M5/46 ,  A61M2005/2407 ,  A61M2005/2488

    摘要： An intravitreal injection system for administering a pharmacological agent formulation to an intravitreal compartment of an eye, comprising (i) an injection member coupled to, or comprising, an internal formulation chamber that is adapted to receive and contain the pharmacological agent formulation therein, (ii) a needle having a first end that is in communication with a formulation chamber and a second injection end, and (iii) a movable platform for positioning the system on the eye, guiding the needle, and limiting the penetration depth of the needle into the eye.

    摘要翻译： 一种玻璃体内注射系统，用于向眼睛的玻璃体腔内施用药物制剂，其包含（i）与适于在其中接受和容纳其药理学制剂的内部制剂室耦合或包含的注射构件（ii） ）具有与制剂室和第二注射端连通的第一端的针，以及（iii）用于将系统定位在眼睛上的引导针，并且将针的穿入深度限制到 眼。