公开(公告)号：US5417715A

公开(公告)日：1995-05-23

申请号：US132815

申请日：1993-10-07

申请人： Kjell Noren ,  Sven-Erik Hedberg ,  Pia Hagel ,  Kurt Hoegnelid

发明人： Kjell Noren ,  Sven-Erik Hedberg ,  Pia Hagel ,  Kurt Hoegnelid

IPC分类号： A61N1/365 ,  A61N1/368

CPC分类号： A61N1/368 ,  A61N1/36521

摘要： A rate-responsive heart stimulator with a variable stimulation interval contains a measurement device which generates a measurement signal corresponding to the volume of blood in a heart during the blood-filling phase (diastole) and a comparator which compares the measurement signal with a defined threshold value corresponding to a defined degree of blood filling. The comparator generates a control signal when the measurement signal reaches the threshold value, the control signal representing the time elapsing since the last stimulation pulse, and controlling the heart stimulator's stimulation interval.

摘要翻译： 具有可变刺激间隔的速率响应心脏刺激器包含测量装置，该测量装置在血液灌注阶段（舒张期）期间产生对应于心​​脏中的血液体积的测量信号，以及将测量信号与限定阈值进行比较的比较器 值对应于确定的血液灌注程度。 当测量信号达到阈值时，比较器产生控制信号，控制信号表示自上次刺激脉冲以来经过的时间，并且控制心脏刺激器的刺激间隔。

公开(公告)号：US5615684A

公开(公告)日：1997-04-01

申请号：US429614

申请日：1995-04-27

申请人： Pia Hagel ,  Kjell Noren ,  Kurt Hoegnelid

发明人： Pia Hagel ,  Kjell Noren ,  Kurt Hoegnelid

IPC分类号： A61B5/022 ,  A61N1/362 ,  A61N1/365 ,  A61N1/39 ,  A61B5/021

CPC分类号： A61N1/36564 ,  A61N1/3621 ,  A61N1/3956

摘要： A device for detecting hemodynamic conditions in a heart, in particular conditions corresponding to dangerous arrhythmias contains a sensing unit for a physiological variable, such as blood pressure, the unit emitting a signal on the basis of the variable having an average value, a signal conditioning unit connected to the sensing unit, a calculation unit connected to the signal conditioning unit and a comparator after the calculation unit. The calculation unit is devised to calculate a variability measure relative to the signal's average value, the variability measure being correlated to average blood pressure, and the variability measure is compared in the comparator to an adjustable threshold value corresponding to a specific hemodynamic condition, whereupon the comparator emits an indication signal when the variability measure falls below the threshold value.

摘要翻译： 用于检测心脏中的血液动力学状况的装置，特别是与危险性心律失常相对应的条件包括用于生理变量例如血压的感测单元，该单元基于具有平均值的变量发出信号，信号调理 连接到感测单元的单元，连接到信号调节单元的计算单元和计算单元之后的比较器。 计算单元被设计为计算相对于信号平均值的可变性度量，可变性度量与平均血压相关，并且可变性度量在比较器中被比较到对应于特定血液动力学条件的可调阈值， 当可变性测量值低于阈值时，比较器发出指示信号。

公开(公告)号：US5385576A

公开(公告)日：1995-01-31

申请号：US101727

申请日：1993-08-04

申请人： Kjell Noren ,  Pia Hagel ,  Kurt Hoegnelid

发明人： Kjell Noren ,  Pia Hagel ,  Kurt Hoegnelid

IPC分类号： A61B5/05 ,  A61B5/053 ,  A61N1/365 ,  A61N1/39

CPC分类号： A61N1/36521 ,  A61B5/0535 ,  A61N1/3962 ,  A61N1/395

摘要： In a method and apparatus for detecting ventricular fibrillation, a measured impedance signal, dependent on the blood volume in the heart, is evaluated, and ventricular fibrillation is assumed to be present if the level of the measured impedance signal falls below a predetermined threshold. This is based on the perception that as the heart fills with blood, given the presence of ventricular fibrillation, the level of the measured impedance signal will decrease. The apparatus also includes circuitry for treating the detected ventricular fibrillation.

摘要翻译： 在用于检测心室颤动的方法和装置中，评估取决于心脏中的血液体积的测量阻抗信号，并且如果测得的阻抗信号的电平低于预定阈值，则认为存在心室颤动。 这是基于以下认识：当心脏充满血液时，鉴于心室颤动的存在，测得的阻抗信号的水平将降低。 该装置还包括用于治疗所检测的心室颤动的电路。

公开(公告)号：US5722994A

公开(公告)日：1998-03-03

申请号：US714310

申请日：1996-09-18

申请人： Kjell Noren ,  Pia Hagel

发明人： Kjell Noren ,  Pia Hagel

IPC分类号： A61N1/39

CPC分类号： A61N1/3956

摘要： An implantable defibrillator has an electrode lead system a sensing unit for sensing the condition of the heart and emitting a condition signal corresponding to that condition, a control unit for determining the heart's condition from the condition signal and, if a state of fibrillation is present, sending a command signal to a shock pulse generator, which, depending on the command signal, delivers at least one defibrillation shock to the heart via the electrode lead system. The shock being formal of one or more low-energy pulses with an energy less than 2 Joules and a very high voltage, i.e. more than 1,000 Volts. Each low-energy pulse thus has a voltage greatly exceeding the voltage in a conventional defibrillation shock and less energy than the energy in a conventional defibrillation shock.

摘要翻译： 可植入除颤器具有电极引导系统，用于感测心脏状况并发出与该状态相对应的状态信号的感测单元，用于根据状态信号确定心脏状况的控制单元，如果存在原纤维状态， 向冲击脉冲发生器发送命令信号，该脉冲发生器根据命令信号经由电极引导系统向心脏传递至少一次除颤电击。 一种或多种能量小于2焦耳的低能量脉冲和非常高的电压（即大于1000伏特）的形式的冲击。 因此，每个低能量脉冲具有大大超过常规除颤电击中的电压的电压和比常规除颤电击中的能量更少的能量。

公开(公告)号：US5405365A

公开(公告)日：1995-04-11

申请号：US186250

申请日：1994-01-24

申请人： Kurt Hoegnelid ,  Kjell Noren ,  Liliane Wecke ,  Jan Ljungstroem

发明人： Kurt Hoegnelid ,  Kjell Noren ,  Liliane Wecke ,  Jan Ljungstroem

IPC分类号： A61N1/08 ,  A61N1/36 ,  A61N1/365 ,  A61N1/37 ,  A61N1/30

CPC分类号： A61N1/3712 ,  A61N1/3706

摘要： Implantable medical device comprising a device for stimulating tissue contractions with adjustable stimulation intensity, whereby the stimulation intensity is set such that a stimulated event is detected after stimulation with a detector device. The detector device detects stimulated tissue contractions in a signal corresponding to the chronological curve of the electrical impedance of the tissue to be stimulated.

摘要翻译： 可植入医疗装置包括用于以可调节的刺激强度刺激组织收缩的装置，由此设定刺激强度，使得在用检测器装置刺激之后检测到刺激事件。 检测器装置检测对应于待刺激组织的电阻抗的时间曲线的信号中的刺激组织收缩。

公开(公告)号：US5427112A

公开(公告)日：1995-06-27

申请号：US51250

申请日：1993-04-23

申请人： Kjell Noren ,  Kurt Hoegnelid

发明人： Kjell Noren ,  Kurt Hoegnelid

IPC分类号： A61B5/0452 ,  A61N1/365 ,  A61B5/00

CPC分类号： A61N1/36585 ,  A61N1/36507

摘要： A device for analyzing the function of a heart, containing a measurement unit for generating a first measurement signal related to a first electrical or mechanical heart variable and an evaluation unit for evaluating the measurement signal, further contains a circuitry for generating a parameter signal related to a heart variable, the evaluation unit analyzing the related values for the measurement signal and the parameter signal. The device can be used for detecting a number of functional aberrations, such as bradycardia, tachyarrhythmia, retrograde conduction, ischemia and ectopia, and for controlling pacemakers and defibrillators.

摘要翻译： 一种用于分析心脏功能的装置，包括用于产生与第一电气或机械心脏变量相关的第一测量信号的测量单元和用于评估测量信号的评估单元，还包括用于产生与 心脏变量，评估单元分析测量信号和参数信号的相关值。 该装置可用于检测许多功能异常，例如心动过缓，快速性心律失常，逆行传导，缺血和异位，以及用于控制起搏器和除颤器。

公开(公告)号：US08812109B2

公开(公告)日：2014-08-19

申请号：US13593334

申请日：2012-08-23

申请人： Andreas Blomqvist ,  Kjell Noren

发明人： Andreas Blomqvist ,  Kjell Noren

IPC分类号： A61N1/00

CPC分类号： A61N1/00 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/36564 ,  A61N1/3682 ,  A61N1/3684

摘要： In an implantable medical device and a method for stimulating a heart of a patient, at least one left atrial pressure (LAP) signal over a cardiac cycle is obtained. The A-wave is identified using the LAP signal and a maximum positive rate of change of the A-wave of the LAP signal is determined. The maximum positive rate of change of the A-wave corresponds to the rate which the pressure in the atrium raises as the atria contraction forces more blood into the ventricle during the very last stage of diastole. Further, AV and/or VV delay is adjusted in response to the maximum positive rate of change of the A-wave, wherein a reduction of the maximum positive rate of change of the A-wave indicates an AV and/or VV delay providing an enhanced hemodynamic performance.

摘要翻译： 在可植入医疗装置和刺激患者心脏的方法中，获得心动周期上的至少一个左心房压力（LAP）信号。 使用LAP信号识别A波，并确定LAP信号的A波的最大正比率。 A波的最大阳性变化率对应于心房收缩期间压力升高的速率，因为心房收缩在舒张期的最后阶段迫使更多的血液进入心室。 此外，AV和/或VV延迟响应于A波的最大正的变化速率而被调整，其中A波的最大正的变化率的减小表示AV和/或VV延迟提供 增强血液动力学性能。

公开(公告)号：US08798765B2

公开(公告)日：2014-08-05

申请号：US13471167

申请日：2012-05-14

申请人： Kjell Noren ,  Anders Bjorling ,  Tomas Svensson ,  Sven-Erik Hedberg ,  Allen Keel ,  Stuart Rosenberg ,  Kyungmoo Ryu

发明人： Kjell Noren ,  Anders Bjorling ,  Tomas Svensson ,  Sven-Erik Hedberg ,  Allen Keel ,  Stuart Rosenberg ,  Kyungmoo Ryu

IPC分类号： A61N1/365 ,  A61N1/372 ,  A61N1/368

CPC分类号： A61N1/36507 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/37252

摘要： CRT settings for an implantable medical device are determined by applying pacing pulses to heart chambers of a scheme of different combinations of interchamber delays. A respective width parameter value representing an R or P wave width is determined for each such delay combination based on an ECG representing signal and the width parameter values are employed to estimate a parametric model defining the width parameter as a function of interchamber delays. Candidate interchamber delays that minimize the width parameter are determined from the parametric model and employed to determine optimal CRT settings. The technique provides an efficient way of finding optimal CRT settings when multiple pacing sites are available in a heart chamber.

摘要翻译： 用于可植入医疗装置的CRT设置通过将不同组合的车间延迟的方案应用于心室来进行起搏脉冲来确定。 基于ECG表示信号为每个这样的延迟组合确定表示R或P波宽的相应宽度参数值，并且使用宽度参数值来估计定义作为间歇延迟的函数的宽度参数的参数模型。 从参数模型中确定最小化宽度参数的候选车间延迟，并用于确定最佳CRT设置。 该技术提供了一种在心室中可用多个起搏部位时可以找到最佳CRT设置的有效方式。

公开(公告)号：US08211032B2

公开(公告)日：2012-07-03

申请号：US13191253

申请日：2011-07-26

申请人： Stuart O. Schecter ,  Kjell Noren

发明人： Stuart O. Schecter ,  Kjell Noren

IPC分类号： A61B5/0452

CPC分类号： A61N1/36514 ,  A61N1/36578

摘要： A first lead provides therapeutic stimulation to the heart and includes a first mechanical sensor that measures physical contraction and relaxation of the heart. A controller induces delivery of therapeutic stimulation via the first lead. The controller receives signals from the first mechanical sensor indicative of the contraction and relaxation; develops a template signal that corresponds to the contraction and relaxation; and uses the template signal to modify the delivery of therapeutic stimulations. In another arrangement, a second lead, with a second mechanical sensor also provides signals to the controller indicative of contraction and relaxation. The first mechanical sensor is adapted to be positioned at the interventricular septal region of the heart, and the second mechanical sensor is adapted to be positioned in the lateral region of the left ventricle. The controller processes the signals from the first mechanical sensor and the second mechanical sensor to develop a dysynchrony index.

摘要翻译： 第一个引线提供对心脏的治疗刺激，并且包括测量心脏的身体收缩和松弛的第一机械传感器。 控制器通过第一引线诱导治疗性刺激。 控制器从第一机械传感器接收指示收缩和松弛的信号; 开发对应于收缩和放松的模板信号; 并使用模板信号修改治疗刺激的递送。 在另一种布置中，具有第二机械传感器的第二引线还向控制器提供指示收缩和松弛的信号。 第一机械传感器适于定位在心脏的室间隔区域，并且第二机械传感器适于定位在左心室的侧向区域中。 控制器处理来自第一机械传感器和第二机械传感器的信号以产生异步指数。

公开(公告)号：US20110245701A1

公开(公告)日：2011-10-06

申请号：US13076627

申请日：2011-03-31

申请人： Anders Bjorling ,  Malin Hollmark ,  Tomas Svensson ,  Stefan Hjelm ,  Kjell Noren ,  Karin Jarverud

发明人： Anders Bjorling ,  Malin Hollmark ,  Tomas Svensson ,  Stefan Hjelm ,  Kjell Noren ,  Karin Jarverud

IPC分类号： A61B5/0456 ,  A61N1/39

CPC分类号： A61B5/0456 ,  A61B5/0031 ,  A61B5/053 ,  A61B5/7264 ,  A61N1/3621 ,  A61N1/36521 ,  A61N1/3702 ,  A61N1/3925 ,  A61N1/3962

摘要： An implantable medical device, is designed to collect a signal representative of the electric activity of the heart and determine a cardiogenic impedance signal for at least a portion of the heart. An R-wave detector of the IMD detects the timing of an R-wave during a cardiac cycle based on the signal representative of the electric activity. A minimum detector detects the timing of a cardiogenic impedance minimum in the cardiogenic impedance signal and within a systolic time window of the cardiac cycle. A detected arrhythmia is then classified by the IMD based on the timing of the R-wave detected by the R-wave detector and the timing of the cardiogenic impedance minimum detected by the minimum detector.

摘要翻译： 可植入医疗装置被设计成收集表示心脏的电活动的信号，并确定至少一部分心脏的心源性阻抗信号。 基于代表电活动的信号，IMD的R波检测器在心动周期中检测R波的定时。 最小检测器检测心源性阻抗信号中心源性阻抗最小值的定时，并在心动周期的收缩时间窗内检测。 然后，基于由R波检测器检测到的R波的定时和由最小检测器检测的心源阻抗最小值的定时，通过IMD对检测到的心律失常进行分类。