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    Determination of cardiac resynchronization therapy settings
    1.
    发明授权
    Determination of cardiac resynchronization therapy settings 有权
    心脏再同步治疗设置的测定

    公开(公告)号：US08798765B2

    公开(公告)日：2014-08-05

    申请号：US13471167

    申请日：2012-05-14

    申请人： Kjell Noren ,  Anders Bjorling ,  Tomas Svensson ,  Sven-Erik Hedberg ,  Allen Keel ,  Stuart Rosenberg ,  Kyungmoo Ryu

    发明人： Kjell Noren ,  Anders Bjorling ,  Tomas Svensson ,  Sven-Erik Hedberg ,  Allen Keel ,  Stuart Rosenberg ,  Kyungmoo Ryu

    IPC分类号： A61N1/365 ,  A61N1/372 ,  A61N1/368

    CPC分类号： A61N1/36507 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/37252

    摘要： CRT settings for an implantable medical device are determined by applying pacing pulses to heart chambers of a scheme of different combinations of interchamber delays. A respective width parameter value representing an R or P wave width is determined for each such delay combination based on an ECG representing signal and the width parameter values are employed to estimate a parametric model defining the width parameter as a function of interchamber delays. Candidate interchamber delays that minimize the width parameter are determined from the parametric model and employed to determine optimal CRT settings. The technique provides an efficient way of finding optimal CRT settings when multiple pacing sites are available in a heart chamber.

    摘要翻译： 用于可植入医疗装置的CRT设置通过将不同组合的车间延迟的方案应用于心室来进行起搏脉冲来确定。 基于ECG表示信号为每个这样的延迟组合确定表示R或P波宽的相应宽度参数值，并且使用宽度参数值来估计定义作为间歇延迟的函数的宽度参数的参数模型。 从参数模型中确定最小化宽度参数的候选车间延迟，并用于确定最佳CRT设置。 该技术提供了一种在心室中可用多个起搏部位时可以找到最佳CRT设置的有效方式。

    DETERMINATION OF CARDIAC RESYNCHRONIZATION THERAPY SETTINGS
    2.
    发明申请
    DETERMINATION OF CARDIAC RESYNCHRONIZATION THERAPY SETTINGS 有权
    心脏康复治疗方法的确定

    公开(公告)号：US20120310296A1

    公开(公告)日：2012-12-06

    申请号：US13471167

    申请日：2012-05-14

    申请人： Kjell Noren ,  Anders Bjorling ,  Tomas Svensson ,  Sven-Erik Hedberg ,  Allen Keel ,  Stuart Rosenberg ,  Kyungmoo Ryu

    发明人： Kjell Noren ,  Anders Bjorling ,  Tomas Svensson ,  Sven-Erik Hedberg ,  Allen Keel ,  Stuart Rosenberg ,  Kyungmoo Ryu

    IPC分类号： A61N1/365

    CPC分类号： A61N1/36507 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/37252

    摘要： CRT settings for an implantable medical device are determined by applying pacing pulses to heart chambers of a scheme of different combinations of interchamber delays. A respective width parameter value representing an R or P wave width is determined for each such delay combination based on an ECG representing signal and the width parameter values are employed to estimate a parametric model defining the width parameter as a function of interchamber delays. Candidate interchamber delays that minimize the width parameter are determined from the parametric model and employed to determine optimal CRT settings. The technique provides an efficient way of finding optimal CRT settings when multiple pacing sites are available in a heart chamber.

    摘要翻译： 用于可植入医疗装置的CRT设置通过将不同组合的车间延迟的方案应用于心室来进行起搏脉冲来确定。 基于ECG表示信号为每个这样的延迟组合确定表示R或P波宽的相应宽度参数值，并且使用宽度参数值来估计定义作为间歇延迟的函数的宽度参数的参数模型。 从参数模型中确定最小化宽度参数的候选车间延迟，并用于确定最佳CRT设置。 该技术提供了一种在心室中可用多个起搏部位时可以找到最佳CRT设置的有效方式。

    ARRHYTHMIA CLASSIFICATION
    6.
    发明申请
    ARRHYTHMIA CLASSIFICATION 有权
    ARRHYTHMIA分类

    公开(公告)号：US20110245701A1

    公开(公告)日：2011-10-06

    申请号：US13076627

    申请日：2011-03-31

    申请人： Anders Bjorling ,  Malin Hollmark ,  Tomas Svensson ,  Stefan Hjelm ,  Kjell Noren ,  Karin Jarverud

    发明人： Anders Bjorling ,  Malin Hollmark ,  Tomas Svensson ,  Stefan Hjelm ,  Kjell Noren ,  Karin Jarverud

    IPC分类号： A61B5/0456 ,  A61N1/39

    CPC分类号： A61B5/0456 ,  A61B5/0031 ,  A61B5/053 ,  A61B5/7264 ,  A61N1/3621 ,  A61N1/36521 ,  A61N1/3702 ,  A61N1/3925 ,  A61N1/3962

    摘要： An implantable medical device, is designed to collect a signal representative of the electric activity of the heart and determine a cardiogenic impedance signal for at least a portion of the heart. An R-wave detector of the IMD detects the timing of an R-wave during a cardiac cycle based on the signal representative of the electric activity. A minimum detector detects the timing of a cardiogenic impedance minimum in the cardiogenic impedance signal and within a systolic time window of the cardiac cycle. A detected arrhythmia is then classified by the IMD based on the timing of the R-wave detected by the R-wave detector and the timing of the cardiogenic impedance minimum detected by the minimum detector.

    摘要翻译： 可植入医疗装置被设计成收集表示心脏的电活动的信号，并确定至少一部分心脏的心源性阻抗信号。 基于代表电活动的信号，IMD的R波检测器在心动周期中检测R波的定时。 最小检测器检测心源性阻抗信号中心源性阻抗最小值的定时，并在心动周期的收缩时间窗内检测。 然后，基于由R波检测器检测到的R波的定时和由最小检测器检测的心源阻抗最小值的定时，通过IMD对检测到的心律失常进行分类。

    HEMODYNAMIC STATUS ASSESSMENT
    7.
    发明申请
    HEMODYNAMIC STATUS ASSESSMENT 有权
    动态状态评估

    公开(公告)号：US20130325359A1

    公开(公告)日：2013-12-05

    申请号：US14000844

    申请日：2011-03-18

    申请人： Karin Jarverud ,  Anders Bjorling ,  Malin Hollmark ,  Kjell Noren ,  Tomas Svensson ,  Stefan Hjelm

    发明人： Karin Jarverud ,  Anders Bjorling ,  Malin Hollmark ,  Kjell Noren ,  Tomas Svensson ,  Stefan Hjelm

    IPC分类号： G06F19/00

    CPC分类号： G06F19/34 ,  A61B5/0464 ,  A61B5/0538 ,  A61N1/36521 ,  A61N1/36535 ,  G06F19/00 ,  G06F19/12 ,  G06F19/24 ,  G16H50/50

    摘要： A patient-specific hemodyanmic status model is determined from impedance data collected during periods of normal and abnormal hemodynamic status by deriving parameter values of a set of multiple impedance-derivable parameters from impedance signals collected during periods of normal hemodynamic status and in connection with periods of abnormal hemodynamic status. The parameter values are employed to estimate coefficients of a linear parametric status model. These coefficients can then be used together with parameter values determined from impedance signals determined during status assessment periods in order to determine a current hemdoynamic status of the patient.

    摘要翻译： 通过从正常血液动力学状态期间收集的阻抗信号中导出一组多个阻抗可导出参数的参数值，并与正常血液动力学状态期间相关联的时期，从正常和异常血液动力学状态期间收集的阻抗数据确定患者特异性血液动力学状态模型 异常血液动力学状态。 参数值用于估计线性参数状态模型的系数。 然后可以将这些系数与在状态评估周期期间确定的阻抗信号确定的参数值一起使用，以便确定患者的当前血液动力学状态。

    Cardiac stimulating and detecting device, system and method for identifying far field signals
    8.
    发明申请
    Cardiac stimulating and detecting device, system and method for identifying far field signals 有权
    用于识别远场信号的心脏刺激和检测装置，系统和方法

    公开(公告)号：US20050004607A1

    公开(公告)日：2005-01-06

    申请号：US10864064

    申请日：2004-06-09

    申请人： Anders Bjorling ,  Sven-Erik Hedberg ,  Nils Holmstrom

    发明人： Anders Bjorling ,  Sven-Erik Hedberg ,  Nils Holmstrom

    IPC分类号： A61N1/362 ,  A61N1/368 ,  A61N1/37

    CPC分类号： A61N1/37 ,  A61N1/3627 ,  A61N1/3684 ,  Y10S128/901

    摘要： In an implantable heart stimulating device, system and method, a control circuit has first and second circuits for sensing and pacing. The first circuit can be connected to a first electrode member suited to be positioned in or at a first ventricle of the heart. The second circuit can be connected to a second electrode member suited to be positioned in or at a second ventricle of the heart. The control circuit is able to detect whether signals sensed by the second circuit are likely to be far field signals. The control circuit performs this detection by at least determining whether, during a predetermined time (length, more signals are sensed by the second circuit than by the first circuit.

    摘要翻译： 在可植入心脏刺激装置，系统和方法中，控制电路具有用于感测和起搏的第一和第二电路。 第一电路可以连接到适于定位在心脏的第一心室中或第一心室处的第一电极构件。 第二电路可以连接到适于定位在心脏的第二心室中或第二心室处的第二电极构件。 控制电路能够检测由第二电路感测的信号是否可能是远场信号。 控制电路通过至少确定在预定时间（长度，由第二电路感测到的信号多于第一电路的信号）来执行该检测。

    Detection of diastolic heart failure
    9.
    发明申请
    Detection of diastolic heart failure 有权

    公开(公告)号：US20060149327A1

    公开(公告)日：2006-07-06

    申请号：US10562109

    申请日：2004-04-26

    申请人： Sven-erik Hedberg ,  Anders Bjorling ,  Maria Torpo ,  Karin Ljungstrom

    发明人： Sven-erik Hedberg ,  Anders Bjorling ,  Maria Torpo ,  Karin Ljungstrom

    IPC分类号： A61N1/368

    CPC分类号： A61B5/021 ,  A61B5/02154 ,  A61N1/3627 ,  A61N1/36564 ,  A61N1/3702 ,  G06F19/00

    摘要： An implantable medical apparatus for detecting diastolic heart failure, DHF, has a DHF determining device for determining at least one blood pressure parameter for detecting a DHF state of the heart of a patient. The DHF determining device includes a pressure measuring unit for measuring pulse pressure in a cardiac cycle for a predetermined workload situation of the patient as the blood pressure parameter, and a comparator compares the measured pulse pressure with a predetermined reference value. A pacemaker includes such an apparatus and a control unit that optimizes pacing therapy depending on the result of the comparison of the measured pulse pressures with the predetermined reference values. A corresponding method of detecting diastolic heart failure, DHF, includes the step of determining at least one blood pressure parameter for detecting a DHF state of the heart of a patient by determining, as said blood pressure parameter, the pulse pressure in a cardiac cycle for a predetermined workload situation of the patient, and the determined pulse pressure is compared with a predetermined reference value.