公开(公告)号：US4666442A

公开(公告)日：1987-05-19

申请号：US711942

申请日：1985-03-15

申请人： Piero Arru ,  Gioachino Bona ,  Maria Curcio ,  Franco Vallana

发明人： Piero Arru ,  Gioachino Bona ,  Maria Curcio ,  Franco Vallana

IPC分类号： A61F2/00 ,  A61F2/24 ,  A61L27/30

CPC分类号： A61F2/2412 ,  A61F2/2409 ,  A61L27/303 ,  A61F2220/0075 ,  A61F2310/00574

摘要： A cardiac valve prosthesis comprises an annular frame and a valve sleeve with a plurality of valve flaps which are forced apart by the blood passing through the prosthesis in one direction and which are mutually coapted by blood flow in the opposite direction. The frame of the prosthesis includes a rigid or semi-rigid stent constituted by a tubular body with a ring of apertures and with first and second end edges which, in the implanted position of the prosthesis, are respectively upstream and downstream with respect to the direction of flow of the blood through the prosthesis. Biocompatible textile completely covers the rigid stent: the covering has associated suture stitches some of which extend through the apertures of the said ring to attach the covering to the stent itself. The valve sleeve includes two sheets of biological tissue sutured together and wound into a tube, the radially outermost one having a shape which substantially reproduces the shape of the stent of the frame and the radially innermost one whereof, carrying the valve flaps, has a collar end portion which can be turned outwardly of the frame at the first end edge of the stent. The valve sleeve is fixed to the frame by further suture stitches, sone of which extend through the apertures in the ends of the appendages of the frame stent. Other suture stitches connect the end edge of the collar end portion of the radially inner sheet to the covering of biocompatible textile.

摘要翻译： 心脏瓣膜假体包括环形框架和具有多个瓣膜的阀套，所述阀瓣被血液在一个方向上穿过假体而被迫使其隔开，并且通过相反方向上的血流相互叠加。 假体的框架包括刚性或半刚性支架，其由具有孔环的管状体构成，并且具有第一和第二端边缘，其在假体的植入位置中相对于方向分别在上游和下游 血液通过假体流动。 生物相容性织物完全覆盖刚性支架：覆盖物具有相关联的缝合线迹，其中一些线延伸穿过所述环的孔，以将覆盖物附着到支架本身。 阀套包括缝合在一起并缠绕在管中的两片生物组织，径向最外侧的一个生物组织具有基本上再现框架的支架形状的形状，并且承载阀瓣的径向最内侧的形状具有凸缘 端部可以在支架的第一端边缘处向框架外侧转动。 阀套通过进一步的缝合线缝合到框架上，其中的一个缝合线延伸穿过框架支架的附件的端部中的孔。 其他缝合针迹将径向内片的颈圈端部的端缘连接到生物相容性织物的覆盖物上。

公开(公告)号：US5078737A

公开(公告)日：1992-01-07

申请号：US419071

申请日：1989-10-10

申请人： Gioachino Bona ,  Stefano Rinaldi ,  Franco Vallana

发明人： Gioachino Bona ,  Stefano Rinaldi ,  Franco Vallana

IPC分类号： A61F2/24

CPC分类号： A61F2/2403 ,  Y10T137/7839

摘要： The thickness of the obturator (3) increases gradually from the central region (C.sub.9 C.sub.10) towards the ends (P.sub.9, P.sub.10) of the edge (6) nearest to the axis of articulation (5) to the prosthesis, and decreases gradually or is constant from that edge to the other end edge (7) which forms the outer edge of the obturator.

公开(公告)号：US4423525A

公开(公告)日：1984-01-03

申请号：US313843

申请日：1981-10-22

申请人： Franco Vallana ,  Gioachino Bona

发明人： Franco Vallana ,  Gioachino Bona

IPC分类号： A61F2/24 ,  A61F1/22

CPC分类号： A61F2/2409 ,  A61F2/2406 ,  Y10T137/7898 ,  Y10T137/7903

摘要： The prosthesis comprises an annular frame and a disc-shaped obturator which is coupled to the frame and is pivotable, under the action of the blood flow, between an open annular position and a closed angular position, so as to allow the flow of blood through the aperture of the annular frame in one direction and the interruption of the flow in the opposite direction, respectively. The obturator is coupled to the frame in such a way that, in the open position, it may orient itself in a direction substantially perpendicular to the plane of the frame. The side of the obturator which faces away from the central axis of the annular frame in the open angular position is defined, at least in its peripheral part, by a surface which is generated by the rotation, about the central axis of the obturator, of a curve the locus of the centers of curvature of which lies on the opposite side of this curve from a curve which generates, by rotation around the central axis, a surface defining the other side of the obturator.

摘要翻译： 假体包括环形框架和盘形闭塞器，其联接到框架并且在血流的作用下可枢转在开放的环形位置和闭合的角位置之间，以允许血液流过 环形框架在一个方向上的孔径和分别在相反方向上的流动中断。 闭塞器以这样的方式联接到框架，使得在打开位置，其可以在基本上垂直于框架的平面的方向上定向自身。 至少在其周边部分中，封闭器的面向远离环形框架的中心轴线的侧面，该表面由围绕闭塞器的中心轴线的旋转产生的表面 其曲率中心的轨迹位于该曲线的与该中心轴线周围旋转的曲线相反侧的轨迹，该曲线限定了闭塞器另一侧的表面。

公开(公告)号：US5002567A

公开(公告)日：1991-03-26

申请号：US278273

申请日：1988-11-30

申请人： Gioachino Bona ,  Stefano Rinaldi ,  Franco Vallana

发明人： Gioachino Bona ,  Stefano Rinaldi ,  Franco Vallana

IPC分类号： A61F2/24

CPC分类号： A61F2/2406 ,  Y10T137/7839 ,  Y10T137/7898

摘要： In a prosthetic heart valve comprising a generally annular stent and at least two obturators mounted in the stent so as to be above to pivot between an open position and a closed position, the stent is provided with at least one element which projects inwardly of the stent itself, while each of the obturators has recesses which cooperate with the projecting element of the stent with clearance in a generally-hinged configuration which enables the obturators to pivot between the open position and the closed position.

公开(公告)号：US5611127A

公开(公告)日：1997-03-18

申请号：US589199

申请日：1996-01-22

申请人： Leonardo Ceriani ,  Gioachino Bona

发明人： Leonardo Ceriani ,  Gioachino Bona

IPC分类号： A61F2/06 ,  D04B1/20 ,  C08G79/02 ,  D04B21/00

CPC分类号： D04B21/02 ,  A61F2/06 ,  D10B2509/06 ,  Y10S623/901 ,  Y10S623/924

摘要： The prosthesis is manufactured by knitting a foundation yarn with a high degree of heat-shrinkability and at least one effect yarn which is substantially heat stable, immersing the resulting fabric in boiling water so as to shrink the foundation yarn and thereby reduce its permeability to liquids while not affecting the effect yarn significantly so that it is possible to obtain good velvet effects without resorting to very high overfeed rates for the effect yarn.

摘要翻译： 该假体是通过编织具有高热收缩性的基础纱线和至少一种实质上热稳定的效果纱线来制造的，将所得织物浸入沸水中以使基础纱线收缩，从而降低其对液体的渗透性 而不会显着影响纱线，从而可以获得良好的天鹅绒效果，而不会对效果纱线产生非常高的过量进给速度。